Amino Acid Profiling of Follicular Fluid in Assisted Reproduction Reveals Important Roles of Several Amino Acids in Patients with Insulin Resistance.

The global prevalence of insulin resistance (IR) is increasing continuously, influencing metabolic parameters and fertility. The metabolic changes due to IR can alter the molecular composition of plasma and other body fluids. Follicular fluid (FF) is derived mainly from plasma, and it is a critical microenvironment for the developing oocytes. It contains various metabolites and amino acids, and the quality of the oocytes is linked at least partially to amino acid metabolism. Our goal was to quantitatively determine the amino acid (AA) profile of FF in IVF patients and to compare IR and non-insulin resistance (NIR) groups to investigate the AA changes in their FF. Using UHPLC-based methods, we quantified the main 20 amino acids from human FF samples in the IR and NIR groups. Several amino acids (aspartate, glycine, glutamate, and cysteine) differed significantly (p < 0.05 or less) between the two groups. The most significant alterations between the IR and NIR groups were related to the glutathione metabolic pathway involving glycine, serine, and threonine. Since insulin resistance alters the amino acid composition of the FF, the oocytes may undergo metabolism-induced changes resulting in poor oocyte quality and less fertility in the insulin resistance groups.

Ischemic stroke mimics: A comprehensive review.

BACKGROUND: Ischemic stroke is the leading cause of disability and one of the leading causes of death. Ischemic stroke mimics (SMs) can account for a noteble number of diagnosed acute strokes and even can be thrombolyzed. METHODS: The aim of our comprehensive review was to summarize the findings of different studies focusing on the prevalence, type, risk factors, presenting symptoms, and outcome of SMs in stroke/thrombolysis situations. RESULTS: Overall, 61 studies were selected with 62.664 participants. Ischemic stroke mimic rate was 24.8% (15044/60703). Most common types included peripheral vestibular dysfunction in 23.2%, toxic/metabolic in 13.2%, seizure in 13%, functional disorder in 9.7% and migraine in 7.76%. Ischemic stroke mimic have less vascular risk factors, younger age, female predominance, lower (nearly normal) blood pressure, no or less severe symptoms compared to ischemic stroke patients (p < 0.05 in all cases). 61.7% of ischemic stroke patients were thrombolysed vs. 26.3% among SMs (p < 0.001). (p < 0.001). Overall intracranial hemorrhage was reported in 9.4% of stroke vs. 0.7% in SM patients (p < 0.001). Death occurred in 11.3% of stroke vs 1.9% of SM patients (p < 0.001). Excellent outcome was (mRS 0-1) was reported in 41.8% ischemic stroke patients vs. 68.9% SMs (p < 0.001). Apart from HINTS manouvre or Hoover sign there is no specific method in the identification of mimics. MRI DWI or perfusion imaging have a role in the setup of differential diagnosis, but merit further investigation. CONCLUSION: Our article is among the first complex reviews focusing on ischemic stroke mimics. Although it underscores the safety of thrombolysis in this situation, but also draws attention to the need of patient evaluation by physicians experienced in the diagnosis of both ischemic stroke and SMs, especially in vertigo, headache, seizure and conversional disorders.

Prevalence and Risk Factors of Internet Addiction among Hungarian High School Teachers.

The extensive availability of internet has led to the the recognition of problematic internet use (so called internet addiction, IA) mostly involving adolescents. There is limited data about the prevalence of IA in adults. Here we present a study focusing on the prevalence and risk factors of internet addiction among high school teachers. Overall 2500 paper-based questionnaires were successfully delivered and 1817 responses received (response rate of 72.7%). In our study 1194 females (65.7%) and 623 males (34.3%) participated. In a multivariate analysis including of all factors (demographic data, internet habits, comorbidity etc.) age <35 years (OR: 6.098, CI: 5.09-7.08, p < 0.001), male gender (OR = 5.413, CI: 4.39-6.18, p = 0.002), surfing on the internet > 5 h daily (OR 2.568, CI: 2.03-3.39, p < 0.001), having no children (OR: 1.353, CI: 1.13-1.99, p = 0.0248), and having secondary employment (OR = 11.377, CI: 8.67-13.07, p = 0.001) were significantly associated with internet addiction. This is the first study from Hungary showing the prevalence and risk factors of internet addiction among high school teachers. A small, but significant proportion suffered from IA. Our study also draws attention to the risk factors of IA such as younger age, family status and working type.

Neuropathic Low Back Pain and Burnout among Hungarian Workers.

Burnout is an increasingly prevalent syndrome mainly involving those working in human services. Although it is categorized as an occupational phenomenon and not as a medical condition, it seems to be strongly associated with several diseases such as pain syndromes. However, no studies examined the association between neuropathic low back pain and burnout. This questionnaire-based study was carried out between April 2019 and March 2020 in three main sites among teachers, social workers and healthcare workers. Demographic criteria included age, gender, marital status, number of children, type of work, years spent with work, work schedule, legal relation, secondary employment. Included diseases were diabetes, hypertension, ischemic heart disease, generalized pain (pain involving more than one area of the body) and depression. Low back pain was assessed by the painDETECT questionnaire, burnout was measured with the Maslach Burnout Inventory (MBI) and depression was measured by the Beck Depression Inventory. Dysfunctional attitudes were also recorded. Overall, 1500 questionnaires were successfully delivered and 1141 responses received (response rate of 76%). Three hundred social workers, 399 teachers, 339 paramedics, 35 doctors and 68 medical attendants have completed our survey. In a multivariate analysis including of all factors (demographic criteria, burnout, depression, dysfunctional attitudes, comorbidity etc.) neuropathic low back pain was associated with age > 62 (OR = 3.981, p = 0.01), number of children ≥ 2 (OR = 2.638, p = 0.003), job type (being a social worker) (OR = 6.654, p < 0.001), burnout (OR = 2.577, p < 0.001), current depression (OR = 2.397, p < 0.001), and suffering from generalized pain (OR= 4.076, p < 0.001). This is the first study showing the association of burnout and neuropathic low back pain, which is the most common cause of disability. Based on our results neuropathic low back pain and burnout have similar risk factors and consequences which raises the possibility of similar pathophysiology.

Internet Addiction and Burnout in A Single Hospital: Is There Any Association?

The extensive availability of the internet has led to the recognition of problematic internet use, the so-called Internet Addiction (IA), mostly involving adolescents. Burnout can lead to substance abuse or addictive behaviour (such as internet addiction) as a coping method. There are insufficient data about internet addiction and its possible association with burnout in adults, especially among healthcare workers. The aim of our present study was to focus on prevalence and the risk factors of internet addiction and its possible association with burnout among healthcare workers in a single hospital applying a questionnaire-based survey. In total, 49 doctors (10.1%), 198 nurses (40.9%), 123 medical assistant (25.4%), 73 other healthcare workers (15.1%), and 42 (1.7%) healthcare associated workers (cleaning, laundry, etc.) have completed our survey. In a multivariate analysis, IA was associated with age between 18 and 25 (OR: 2.6, p = 0.024), surfing on the internet >5 h daily (OR 25.583, p < 0.001), being single (OR: 4.275, p = 0.006), being childless (OR: 3.81, p = 0.011), working less than five years (OR 2.135, p = 0.048) and job type (being healthcare associated worker, OR: 2.907, p = 0.009). Illicit drug intake (OR 52.494, p < 0.001), and diabetes (OR: 4.122, p = 0.043) were also significantly associated with internet addiction. No association of burnout and IA could be found. A small but significant proportion of our healthcare workers suffered from IA, which was associated with substance abuse and diabetes in multivariate analysis. Our study also draws attention to the risk factors of IA such as younger age, family status, working type and working hours internet use. The possible association of burnout and IA merits further investigation.

Burnout among social workers / A kiégés elofordulása szociális munkások körében.

Összefoglaló. Bevezetés: Napjaink egyik legszélesebb körben emlegetett jelensége a kiégés (burnout), mely a leggyakrabban a segíto szakmákban dolgozókat érinti. Célkituzés: Munkánk célja a kiégés jelenségének komplex vizsgálata szociális munkások körében. Módszerek: A demográfiai adatok felvétele mellett a kiégés vizsgálatához a Maslach Burnout Inventory (MBI) kérdoívet használtuk, a kognitív/viselkedésbeli hibákat, diszfunkcionális elvárásokat pedig a Diszfunkcionális Attitud Skála (DAS) segítségével térképeztük fel. A hangulatzavar kimutatásához a Beck Depresszió Kérdoív rövidített változatát alkalmaztuk, továbbá az Erofeszítés-Jutalom Egyensúlytalanság Kérdoív és a Társas Támogatás Kérdoív is kitöltésre került. Eredmények: Összesen 300 fo töltötte ki a kérdoívet: 106 férfi, 194 no. A munkavállalók döntoen a fiatal/középkorú korcsoporthoz tartoznak, a 26-45 év közöttiek aránya 52,2%. Az átlagos kiégési pontszám 53,9 (SD = 18,7) volt, melybol 105 fo (35,1%) alacsony, 182 fo közepes (60,6%) és 13 fo (4,3%) súlyos kiégéssel érintett. A multivariációs analízis során a noi nem (OR: 5,857), az életkor (OR: 4,126), a munkában eltöltött évek (OR: 2,721), a sokgyermekes család (OR: 2,861) és a társas támogatás hiánya (OR: 2,81) bizonyultak a kiégés független rizikótényezoinek (p<0,05 minden esetben). A depresszió és a kiégés (p<0,001), valamint a diszfunkcionális attitudök és a kiégés között pozitív kapcsolat igazolódott (korrelációs együttható = 0,316; p<0,001). Következtetés: Eredményeink alapján a szociális munkások jelentos része közepes fokú kiégésben, 5%-uk pedig súlyos fokú kiégésben szenved. A kiégésnek vannak befolyásolható (munkahelyi attitudök, társas támogatás) és nem befolyásolható (életkor, nem, család) tényezoi, melyeket az esetleges prevenciós, illetve intervenciós beavatkozások során figyelembe kell venni. Orv Hetil. 2020; 161(44): 1884-1890. INTRODUCTION: Burnout is increasingly prevalent mainly involving employees working in the social sphere. OBJECTIVE: The aim of our study was to examine the complexity of burnout among social workers. METHODS: Baseline demographic data were recorded. Burnout was assessed by the Maslach Burnout Inventory (MBI), and the intensities of dysfunctional attitudes were also studied. Depression was detected by the abbreviated version of the Beck Depression Questionnaire, furthermore social supports and effort-reward imbalance were also examined. RESULTS: Overall 300 employees participated in our study. Age group distribution was young/middle-aged access, the vast majority of the workers was between 25 and 45 years. The mean burnout scale was 53.9 (SD = 18.7), 105 workers had mild (35.1%), 182 moderate (60.6%) and 13 severe (4.3%) burnout. In a multivariate analysis, the female gender (OR: 5.857), the age (OR: 4.126), the years spent with working (OR: 2.721), the number of children (>3) (OR: 2.861) and the lack of social support (OR: 2.81) were independently associated with burnout (p<0.05 in all cases). There was a significant association among burnout, depression and dysfunctional attitudes. CONCLUSION: The vast majority of our social workers suffered from moderate and a small, but a significant proportion from severe burnout. Our work draws attention to the modifiable and unmodifiable risk factors of burnout in this population, which may help in the development of preventive strategies. Orv Hetil. 2020; 161(44): 1884-1890.