Evaluation of Fortetropin in geriatric and senior dogs with reduced mobility.

As pets age, quality of life and mobility can be affected by pain of osteoarthritis and age-related muscle atrophy (sarcopenia). The purpose of this randomized, double-blinded, placebo-controlled study was to evaluate the effects of Fortetropin, a nonthermal-pasteurized, freeze-dried, fertilized egg yolk product, on mobility in senior dogs. Mobility scores were calculated using a standardized and validated client-based survey: the Liverpool Osteoarthritis in Dogs (LOAD) questionnaire. Results showed mild, but statistically significant, improvement of the mobility scores for the treatment group at both week 6 (P = 0.03) and week 12 (P = 0.006) compared to the baseline score. No statistical improvement was noted at any time in the placebo group or between the treatment and placebo group.

Évaluation de Fortetropin chez les chiens gériatriques et âgés à mobilité réduite. À mesure que les animaux de compagnie vieillissent, la qualité de vie et la mobilité peuvent être touchées par la douleur causée par l'arthrose et l'atrophie musculaire liée à l'âge (sarcopénie). Le but de cette étude randomisée, à double insu et contrôlée par placebo était d'évaluer les effets de Fortetropin, un produit non pasteurisé, lyophilisé et fertilisé de jaune d'oeuf, sur la mobilité chez les chiens âgés. Les cotes de mobilité ont été calculées à l'aide d'un sondage standardisé et validé mené auprès des clients, le questionnaire Liverpool Osteoarthritis in Dogs (LOAD). Les résultats ont montré des scores statistiquement améliorés de mobilité pour le groupe de traitement à la semaine 6 (P = 0,03) et à la semaine 12 (P = 0,006) comparés au score de ligne de base. Aucune amélioration statistique n'a été notée à n'importe quel moment dans le groupe de placebo ou entre le groupe de traitement et de placebo.(Traduit par les auteurs).

Evaluation by polymerase chain reaction assay of persistent shedding of pathogenic leptospires in the urine of dogs with leptospirosis.

BACKGROUND: Persistent leptospiruria in naturally infected dogs occurs despite appropriate antibiotic treatment. HYPOTHESIS/OBJECTIVES: To determine the frequency of persistent leptospiruria in naturally infected dogs and the association of persistent leptospiruria with different antibiotic treatments. ANIMALS: Thirty-two dogs of varying age and breed diagnosed with leptospirosis via urine polymerase chain reaction assay (PCR). METHODS: A prospective observational study of dogs diagnosed with leptospirosis was undertaken to determine the frequency of persistent leptospiruria as determined by PCR. Clinical presentation of leptospirosis, antibiotic treatment, serum creatinine concentration, and outcome were recorded. RESULTS: Fifteen of 32 dogs had a negative urine PCR on the first submission in the study, 5 of 15 received only an aminopenicillin. The remaining 17 dogs had a negative urine PCR on the second (n = 6 dogs), third (n = 5), fourth (n = 5), and eighth (n = 1) submissions. Acute kidney injury was reported in 32/32 dogs. Two of 32 dogs developed chronic kidney disease. CONCLUSIONS AND CLINICAL IMPORTANCE: Persistent leptospiruria is common despite treatment with antibiotics frequently recommended for treatment. Follow-up urine PCR to confirm clearance of the organism is recommended in all dogs. In dogs with persistent leptospiruria, chronic kidney disease can develop after acute kidney injury.