Textile composition, not number of layers, impacts interphase pressure and static stiffness index: A pragmatic, comparative analysis of the in vivo interphase pressure of 7 different 2-layer cohesive bandage kits in healthy volunteers.

"OBJECTIVE: The aim of the study was to comparatively evaluate the in vivo interphase pressure (IP) and statis stiffness index (SSI), upon initial application, of 7, 2-layer cohesive bandage kits when applied on healthy volunteers. METHOD: Bandages were applied in random order, on non-consecutive days by a single experienced clinician. The IP at the time of application was measured on the right lower limb of 10 healthy volunteers at 2 different points (B1, C). Measurements were made in 2 positions, supine and standing. There were 2 consecutive applications and measurements made for each compression bandage set. Statistical analysis of the outcome data was performed, utilizing a repeated measures analysis of variance (ANOVA) to determine: the effects of the bandage type on IP and SSI for each of the measurement points and according to the subject's position. Post hoc analyses were performed by Tukey and Bonferroni test to identify significant differences. The dispersion of the recorded pressures within the study population (dispersion between subjects) was assessed by the coefficient of variations. RESULTS: The in vivo IP measured at B1 in the supine position varied from 50.1 mmHg (±5.3) to 73.7 mmHg (±13.4). The in vivo IP measured at C in the supine position varied from 53.2 mmHg (±7.6) to 69.3 mmHg (±10.6). Bonferroni post hoc analyses demonstrated with a 95% confidence interval, there was a significant difference between wraps and placed them into 5 groups for the IP measured at B1, and 3 groups for measurements taken at C. A regression model including the main effects of the wrap and the subject with their interaction were similar for the IP observed at B1 and C in the supine position (r2 = 0.881). The in vivo SSI measured at B1 varied from 11.95 (±5.4) to 6.65 (±4.4). Post hoc analyses similarly demonstrated significant differences placing the wraps into 3 different groups. Statistical analysis of the variability of the IP observed at B1 and C showed there was a significant difference at B1 (P = .001), which was not observed at C (P = .347). CONCLUSION: Sub-bandage pressure measurements produced by the 7, '2-layer cohesive' compression box sets were not equivocal. IP and SSI varied by textile composition, clinically supporting the trial of alternative '2-layer cohesive' compression box set if the desired outcome (ie, wound healing, edema reduction) is not achieved. Additional study in patients with edema is warranted to allow an evidenced-based approached to the selection of a compression bandage set.

Selecting appropriate compression for lymphedema patients: American Vein and Lymphatic Society position statement.

BACKGROUND: Lymphedema is a significant and disabling disorder affecting millions of people worldwide. Compression therapy is an important component of lifelong treatment but the specifics of appropriate compression garment selection and prescribing is not always well understood by practitioners and payers. METHOD: An expert panel of the American Vein and Lymphatic Society was convened to write a Position Statement with explanations and recommendations for the appropriate compression therapy to be used in the treatment of lymphedema patients. RESULT: A Position Statement was produced by the expert panel with recommendations for documentation and compression therapy treatment. Their recommendations were reviewed, edited, and approved by the Guidelines Committee of the society. CONCLUSION: This societal Position Statement provides a useful document for reference for medical care providers for the appropriate compression therapy selection and treatment of patients with lymphedema.

Microgravity and Lymphatics: Why Space Programs Need Lymphedema Physiology Specialists.

Background: The resurgence of space travel in the recent years, both through formally trained astronauts on the International Space Station and the civilian space race to send astrocivilians to Low Earth Orbit and beyond, beckons the need to understand the role of the lymphatic system and role of endothelial glycocalyx when subjected to gravitational alterations. Methods and Results: A comprehensive narrative review of the literature explores a call to action for research and countermeasure development to support the health and well-being of humans subjected to space flight, with particular attention to the role of the lymphatic system and endothelial glycocalyx. Emerging evidence suggests a link between the dysfunction experienced with various physiological processes in microgravity, highlighting the need for more research exploring the role of the lymphatic system in the extremes of gravity and countermeasure development to reduce dysregulation. Conclusion: The synergistic and interdependent relationship of these structures are fundamental to health in space and on Earth.

All edema is lymphedema: progressing lymphedema and wound management to an integrated model of care.

BACKGROUND: Chronic edema affects millions of people in the United States and worldwide. Edema can result from a variety of diseases, trauma, medications, and other contributing factors; however, all edema is related to lymphatic fluid dysregulation. Additionally, lymphatic impairment and integumentary dysfunction are interrelated, leading to complex clinical presentations that require an integrated medical model of care to maximize outcomes. PURPOSE: This narrative review article will highlight the current evidence that details lymphatic physiology, fluid regulation by the endothelial glycocalyx layer, and the interconnectedness of the vascular and integumentary systems leading to a paradigm shift in our understanding of edema, lymphedema, and chronic wounds. Traditional pedagogy remains siloed with respect to the body systems, whereas current evidence indicates a certain interdependence, particularly between and among the venous, lymphatic, and integumentary systems. METHODS: Comprehensive narrative review of the current and past literature (2010-2021 through PubMed, Google Scholar, MEDLINE Complete, UpToDate) focusing on lymphatic physiology, fluid regulation, the endothelial glycocalyx layer, lymphedema, and venous insufficiency. Review focuses on new evidence supporting the interconnectedness of the systems to support a unified medical management approach. RESULTS: All edema is related to lymphatic dysfunction, whether transient or permanent, thereby creating a lymphedema continuum. Further, lymphatic impairment creates cutaneous regions of skin barrier failure, rendering the skin more susceptible to breakdown and chronic wounds. CONCLUSION: A synthesis of the current evidence suggests an interconnected relationship of the lymphatic, venous, and integumentary systems, highlighting the need for a more integrated medical model of care to provide efficient and comprehensive care and improve patient outcomes.

Early Detection of Pressure Injury Using a Forensic Alternate Light Source.

OBJECTIVE: This study aimed to determine if an alternate light source (ALS) can be used to detect tissue trauma before visible manifestations of tissue injury are evident with the naked eye. MATERIALS AND METHODS: Ten participants were recruited and gave consent, and 7 completed the study. Researchers examined and photographed participants' heels in ambient light to establish baseline. A series of photographs using ALS and camera were taken as follows: violet wavelength at 415 nm to 445 nm with yellow lens; blue wavelength at 455 nm to 515 nm with orange lens; and green wavelength at 535 nm to 575 nm with red lens. Participants were examined weekly for 6 consecutive weeks to ascertain skin changes in ambient light and through the ALS. RESULTS: Overt tissue changes were noted when viewed with the ALS and camera compared with visual screens in ambient light. Descriptive statistics were calculated for all wavelengths. Two chi-square tests of independence were run to look for relationships between wavelength and the number of detected injuries (absorption). CONCLUSIONS: Participants presenting with nonblanching erythema in ambient light showed significant tissue absorption under ALS and camera, depicting the actual scope and magnitude of the tissue trauma. Participants with scars, areas of previous injury, and pigmentary changes also showed significant absorption at those sites. These combined findings indicate that ALS can detect tissue trauma and areas at risk not readily visible by the naked eye. This noninvasive tool could help identify patients in the early stages of tissue trauma as well as screen for sites of previous injury that are at risk for subsequent breakdown, saving significant health care dollars and improving outcomes and quality of life.

Biophysical Technologies for Management of Wound Bioburden.

Significance: Chronic wounds commonly have high levels of bioburden and antibiotic-resistant pathogens. This review article focuses on findings from current literature related to four biophysical technologies (ultrasound, electrical stimulation, phototherapy, and negative pressure wound therapy) believed to be beneficial for managing wound bioburden and support healing. Recent Advances and Critical Issues: Recent advances for each modality are provided as a basic synopsis of the technology followed by brief overviews of the most recent literature addressing its effectiveness for managing wound bioburden, and critical issues for each modality are provided as conclusions. Future Directions: This review highlights the need for further clinically relevant studies examining bacterial levels in addition to healing progression for each technology.

Recurring pressure ulcers: identifying the definitions. A National Pressure Ulcer Advisory Panel white paper.

Currently, there is a lack of consensus regarding the accepted terminology pertaining to the pressure ulcer healing progression and recidivism. This lack of uniformity can negatively impact initiation of treatment pathways, completion of appropriate interventions, clinical documentation, medical coding, patient education, discharge planning and healthcare revenue through out the healthcare system. The purpose of this paper is to introduce a standard nomenclature as it pertains to pressure ulcer healing progression and any recidivism that may occur. The National Pressure Ulcer Advisory Panel has formulated a framework of terms regarding pressure ulcer progression. We also developed a clearer nomenclature for lack of progress and recidivism of pressure ulcers. This document should serve as a starting point for the discussion of the pressure ulcer care, research, and terminology.

Tissue destruction classification systems.

Assessing the level of tissue destruction in wounds can be a confusing challenge. This important task is frequently accompanied by questions and the need for clarification to accurately classify the level of damage seen in wounds. The purpose of this article was to present several known classification systems to help clarify this issue for the clinician.

The Use of Collagen Dressings in Long-term Care: A Retrospective Case Series.

The presence of a chronic ulcer presents a challenge to clinicians in long-term care while being both a physical and psychological burden to the residents and their families. Dressings play an important adjunctive role in concert with overall efforts to manage the underlying causes of chronic, non-healing wounds. With more than 2000 dressings and a variety of treatment protocols available, chronic wound management is as much an art as it is science. Each wound requires a unique combination of dressings that is matched to the needs of the patient and the clinical presentation of the wound. Treatment often depends on the skill level of the clinician and the ability to develop appropriate interventions and plan of care. This retrospective series of four case studies serves to demonstrate the improved potential for healing outcomes when collagen dressings are used appropriately. .

The science of compression therapy for chronic venous insufficiency edema.

One of the goals of compression therapy is to enhance healing of a venous leg ulcer. This goal is accomplished by improving venous return and reducing lower extremity edema.

Incidence and prevalence of lymphedema in patients following burn injury: a five-year retrospective and three-month prospective study.

BACKGROUND: Burn injuries and the disease process of lymphedema are complex medical conditions involving the integument. The possibility of a relationship between burn injury and the development of lymphedema was studied. METHODS AND RESULTS: The incidence of lymphedema was explored by conducting a 5-year retrospective chart review on edema related ICD-9 codes. The prevalence of lymphedema was assessed in a prospective study of patients in a burn clinic. The techniques used to diagnose lymphedema were utilized on all patients presenting to clinic with extremity edema. The prospective analysis reviewed the lymphedema tests and measures and burn characteristics to determine those that were appropriate to diagnose or predict the risk of lymphedema in a burn patient. A 6-month follow-up study was also conducted to re-examine subjects initially diagnosed with lymphedema. CONCLUSIONS: The retrospective review did not reveal significant findings to determine incidence of lymphedema following burn injury. The prospective study identified eight patients with a clinical diagnosis of lymphedema. Two of the eight subjects had a previous diagnosis of lymphedema prior to the burn injury. The six remaining subjects represent a prevalence of 1.0%. Specific tests and measures, Stemmer Sign, deepening of skin folds, and the lack of venous alterations, were found to be appropriate measures to diagnose lymphedema in the burn patient population. Specific burn characteristics, circumferential extremity involvement, and fascial excision, also identified burn patients who may be at risk for developing lymphedema. Lastly, the results of the 6-month re-evaluation confirmed the original diagnoses.