Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis.

Objective: The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE.Methods: A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied.Results: Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67-1.11; OR = 0.92, 95%CI: 0.73-1.15, respectively for ε2 and ε4).Conclusion: ApoE polymorphism might not be associated with the risk of PE.

Association between Apolipoprotein E Gene Polymorphism and Alzheimer's Disease in an Iranian Population: A Meta-Analysis.

The development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that the APOE ε4 allele is a genetic risk factor for developing AD, whereas the APOE ε2 and APOE ε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estimate the real association in specific ethnicities. The aim of this study was to investigate the association between the APOE polymorphism and AD in an Iranian population. Our results showed a higher incidence of AD among individuals carrying the APOE ε4 allele (OR = 4.81, 95% CI: 3.28-7.05), more notably in those with the APOE ε4/e4 genotype (OR = 7.47, 95% CI: 2.35-23.73), while carrying the APOE ε3 allele was demonstrated to have a protective effect (OR = 0.40, 95% CI: 0.30-0.54). The association between the APOE ε2 allele and AD was not statically significant. However, further studies focusing on other parameters such as age, sex and environmental conditions are needed to reveal the true association between the APOE polymorphism and AD.

Data on the attitudes of nurses and patient׳s family regarding the family presence in the intensive care unit in Birjand, Iran.

The presence of the patient׳s family on the patient׳s bedside in the intensive care units (ICU) has been a challenging issue among nurses. Therefore, the aim of the data is to evaluate the viewpoints of nurses and the family of patients on the family attendance at the patient bedside in the intensive care units at the educational hospitals in Birjand City. A descriptive cross-sectional study was carried out on 70 nurses working in the intensive care units of the hospitals and 100 members of the family of patients admitted to the intensive care units in 2017. Statistical analysis was carried out by SPSS 16. The findings showed that the average score obtained by nurses and families were 0.46 ± 1.75 and 2.61 ± 0.50, respectively. The data showed that nurses have a negative opinion about the presence of the patients' family regarding the family presence in the Intensive Care Unit ICU (P < 0.001).