RESUMO
In vitro studies were carried out in order to determine the adsorption of tilidine HCl, a narcotic analgesic, by activated charcoal (max. adsorption capacity 185.5 mg/g of charcoal). The path of the adsorption isotherms at pH 1.2 and 7.5 suggests that the in vivo adsorption of tilidine HCl may be increased when the drug passes from the stomach to the intestine, unless the intestinal content exerts a displacing effect. Nevertheless, the adsorption was dependent on the quantity of activated charcoal used, becoming more complete when the quantity of activated charcoal was increased. The effects of additives on the adsorption capacity of activated charcoal were also investigated in vitro. Ethanol, sorbitol and sucrose significantly reduced drug adsorption, while cacao powder, milk and starch had no effect on tilidine adsorption. At an acid pH, Federa Activated Charcoal significantly adsorbed more drug than either Norit A or Activated Charcoal Merck.
Assuntos
Carvão Vegetal , Ácidos Cicloexanocarboxílicos , Tilidina , Adsorção , Líquidos Corporais , Catárticos , Suco Gástrico , Concentração de Íons de Hidrogênio , Intestinos , Modelos Químicos , Espectrofotometria , Equivalência TerapêuticaRESUMO
The mass and infrared spectra of the methyl esters of 9 chlorophenoxy acid herbicides are presented. Ultraviolet data are discussed and proton magnetic resonance spectra are tabulated. Because of the sensitivity of the technique, the mass spectra are most useful for the identification of those compounds in residues, especially by combined gas chromatography-mass spectrometry. The pure herbicides used for the recording of the spectra were obtained by synthesis and recrystallization.
