RESUMO
In addition to membrane rupture, pharmacological doses of oxytocin (2.6 mU/minute rusing stepwise to 422.4 mU/minute) were used in 134 patients and the results compared to those obtained in 144 patients given only physiological doses of oxytocin (2.6 to 13.2 mU/minute). Pharmacological doses of oxytocin gave better results in terms of induction-delivery intervals, incidence of failed inductions and puerperal morbidity. The incidence of hypertonus was similar in both groups and unrelated to oxytocin doses. A uterine activity of 276 Montevideo units, modified to 200 to 220 Montevideo units for grande multiparae, is defined as the goal of oxytocin treatment in induction of labour. A sign of imminent uterine tetany in the intrauterine pressure curve (the 'damping sign') is described.
Assuntos
Trabalho de Parto Induzido , Ocitocina/administração & dosagem , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Feminino , Coração Fetal/efeitos dos fármacos , Humanos , Ocitocina/farmacologia , Gravidez , Contração Uterina/efeitos dos fármacosRESUMO
The effect of diazepam on uterine activity was assessed in a series of 30 patients in established spontaneous labor. The action of diazepam on the frequency and amplitude of contractions, uterine tone and fetal heart rate was monitored internally. An i.v. dose of 10 mg diazepam significantly decreased uterine activity by its direct effect on contraction frequency. No effect on uterine tone was seen. This effect of diazepam on contraction frequency was additional to its tranquilizing and muscle relaxant action.
