A Case of Merkel Cell Carcinoma with Regional Lymph Node and Cutaneous Metastases / 대한피부과학회지

Merkel cell carcinoma is an uncommon malignancy of the skin that was first described by Toker in 1972 and often portends a poor prognosis. We present a case of merkel cell carcinoma in a 69-year-old male who had visited our clinic to evaluate a soft tissue mass without pain or tenderness on the left pretibial area. The mass was diagnosed as a merkel cell carcinoma by excisional biopsy. Metastatic merkel cell carcinorna was found at the left inguinal lymph node and thereafter at the left inguinal area and at the left thigh. Radiotherapy and chemotherapy were used in treating these carcinomas.

A Case of Dermatofibroma with Granular Cells / 대한피부과학회지

Dermatofibroma with granular cells is composed mainly of spindle shaped cells mixed with in-conspicuous foamy cells that contain granular cytoplasm. We present a case of dermatofibroma with granular cells in a 36-year-old male who visited our clinic to evaluate a slow-growing nodule on the medial side of the left lawer leg. He have had the nodule for five years and sometimes felt an itching sensation. Biopsy of the nodule identified a dermal nodular tumor showing cellular spindle cell proliferation admixed with peripheral foamy histiocytes. With the immunohistochemical staining, the granular cell was positive for alpha-1-antitrypsin and CD68, and negative for S-100. A few electron-dense granules were seen in the cytoplasm on the electronmicroscopic study. These results suggested that the granular cells originated from histiocytes.

Rectal Endometriosis: A Case Report of with a Clinical Analysis of Other Cases Reported in Related Korean Literature / 대한소화기내시경학회지

Endometriosis is the abnormal growth of endometrial tissue outside the uterine cavity. Involvement of the gastrointestinal tract is seen in 3~34% of patients affected by this condition. Although the commonest sites involved are the sigmoid colon and rectum, only 4 cases have been reported in Korea. The most frequent symptoms are lower abdominal and pelvic pain typically worsening at the time of menstruation. Bleeding per rectum is uncommon since the mucosa is rarely involved. Endoscopy has not been thought to be helpful in the evaluation of patients with suspected colonic endometriosis. However, endoscopy is often used as the first test in patients with rectal bleeding, excluding malignancy or other sources of bleeding. There are few reports of endoscopic documentation of colorectal endometriosis. A 26 year-old woman having a history of endometriosis with cyclic hematochezia and lower abdominal pain is herein reported. A flexible sigmoidoscopy revealed a protrusion of hyperemic mucosa with a surrounding fold formation on the rectum 8 cm above the anal verge. The subsequent biopsy of the lesion gave rise to a diagnosis of endometriosis.

Two Cases of Cutaneous Cryptoccosis Mimicking Cellulitis / 대한의진균학회지

Crytococcus neofomans is an encapsulated budding yeast with well-defined ecological biotopes and the second most common nose of the fungal infection in immunocompromised patients. It is 18re for a cryptoccosis infection to be localized only to the skin. We report two cases of cryptococcosis mimicking cellulitis. The frist case was suspected as primary cutaneous cyptococcosis in the 57-year-old female SIE patient who had been treated with prednisolone 60 mg/day for 1 month. Erythematous swollen patch developed on the left thigh and subsided spontaneously without relation to the course of 519 after 2 weeks of onset. The second case developed in the 45-year-old female patient with adrenal cancer. Erythematous patches developed on the medial sides of both thighs. The lesions were resistant to the combination therapy of amphotericin B 0-7 mg/kg/day and 5-fluorocytosine 100 mg/kg/day and the patient died after 1 month of treatment.