RESUMO
The toxicity of polychlorotrifluoroethylene oil (3.1 oil) hydraulic fluid is believed to be related to the conversion of neutral chlorotrifluoroethylene (CTFE) oligomers to their corresponding halogenated fatty acids. Male Fischer-344 rats were orally gavaged (1.25 g/kg/d) with two batch formulated 3.1 oils (3.1 oil-C6 and 3.1 oil-C6:C8) and C6 CTFE (trimer) and C8 CTFE (tetramer) oligomers, respectively. All rats exposed to test compounds for 7 days demonstrated significant 2-fold increases in liver weight over controls. After 24-h and 7-day dosings, the amount of tetramer acid formed in the liver was 2x and 11x the amount of trimer acid formed, respectively. In addition to the formation of tetramer acid, rats dosed with tetramer also indicated comparable amounts of trimer acid. These data indicate that toxicity induced by the 3.1 oil may be due to the retention of the tetramer and the resulting persistent high concentrations of halogenated fatty acids.
Assuntos
Clorofluorcarbonetos , Ácidos Graxos/química , Hidrocarbonetos Halogenados/toxicidade , Fígado/efeitos dos fármacos , Administração Oral , Animais , Cromatografia Gasosa , Hidrocarbonetos Halogenados/química , Fígado/química , Masculino , Ratos , Ratos Endogâmicos F344 , Relação Estrutura-AtividadeRESUMO
Fatty acids obtained by saponification of a hexane-soluble fraction of flue-cured tobacco were converted to their methyl esters. The esters were purified by TLC and identified by GC-MS. Qualitative and quantitative results are reported for acids of chain lengths C12-C34.
