Analysis of Plasma Skimming within a Hydrodynamic Bearing Gap for Designing Spiral Groove Bearings in Rotary Blood Pumps.

The blood damage problem inside the narrow hydrodynamic bearing is potentially considered to be solved by applying plasma skimming. However, the consideration of improving plasma skimming has not been included in the design of hydrodynamic bearings. The absence of experimental investigation on revealing the relationship between blood flow and plasma skimming in the bearing gap impedes the design of groove shape for plasma skimming. Thus, the present study was undertaken to evaluate how the blood flow direction and the groove shape affect plasma skimming in the bearing gap. To this end, blood tests using porcine blood were repeated three times with a hematocrit of 0.8%. The bearing gap during the tests was adjusted to 25 µm and the rotational speed was adjusted from 50 rpm to 2500 rpm. The blood flow and plasma skimming effect was evaluated based on image analysis utilizing a high-speed microscope. Results of three tests indicated that the flow direction of RBCs was dominated by the rotating surface in the bearing gap when the rotational speed increased over 1200 rpm. The best plasma skimming effect was observed when the angle between the flow direction of RBCs and the tangent line of the groove was within -10 degrees to 10 degrees. The future study will be conducted with including the consideration of plasma skimming in the bearing shape design. The findings in this study aid the future design and development of hydrodynamic bearing for use in rotary blood pumps.

Contraction model of skeletal muscle driven by external electrical stimulation-Proposal and Identification.

Biohybrid actuators consisting of skeletal muscle and artificial lattice have unique characteristics such as self-growth and self-repair functions. As a first step for developing model-based design and model-based control methods for the biohybrid actuators, we have developed a muscle contraction model. When the stimulation voltage is applied to the muscle, the electrical charges are stored in the dihydropyridine receptor, and the calcium ions are released. According to the concentration of the ions, the contractile elements generate contraction force. We have modeled this phenomenon with three characteristics in the proposed model-electrical dynamic, physiological, and mechanical dynamic characteristics. Unlike the previous models, the proposed model was verified under the condition of tetanus and incomplete tetanus with the muscle length changed. The simulated contraction force showed good agreement with the experimentally measured contraction force generated by the gastrocnemius muscle of a toad.Clinical Relevance- Biohybrid actuators are expected as a new material for medical and assistive devices having a soft and flexible characteristic. This study provides a basic contraction model for such biohybrid actuators.

Development of a resonance generator utilizing incomplete tetanus of skeletal muscle.

Implantable energy harvesting system utilizing contraction of an electrically-stimulated skeletal muscle is proposed for alternative batteries of implantable medical devices. In order to realize high conversion efficiency, we propose a resonance generator utilizing vibration of the skeletal muscle, which is called as incomplete tetanus. Experimental results showed the incomplete tetanus was a suitable form for the energy harvesting and the stimulation at the frequency of 10 Hz was maximized the work of the muscle. Dimensions of the springs of the generator were designed so that its natural frequency was 10 Hz. On the simulation, the maximum generated power was achieved 122.5 µW, which is enough to power the IMDs.Clinical Relevance-The proposed system has a potential to eliminate conventional batteries in the implantable medical devices. It will be beneficial for patients since the periodical surgery for the battery replacement will be avoided.

Design optimization of contactless generator for implantable energy harvesting system utilizing electrically-stimulated muscle.

We propose an energy harvesting device driven by a contraction of an electrically-stimulated skeletal muscle for an alternative battery of implantable medical devices. In order to realize a durable generator, we proposed a contactless plucking mechanism utilizing parallel leaf springs and magnets, with which the generator can be driven without friction. By utilizing this mechanism, the generator can be driven not only in a contraction phase, but also a relaxant phase. We optimized the stiffness of the parallel leaf springs, air gap between the magnets, and magnetic circuit in order to maximize generated power of the generator. The generated power of the prototype in nonliving environment was evaluated. The result showed the protype could achieve 35.8 µW, the value of which is enough to drive the implantable medical devices. Finally, the generated power was evaluated in the ex-vivo experiment using a gastrocnemius muscle of a toad with a weight of 193.4 g. In this experiment, the generator achieved 18.1 µW from only 3.5 g of the skeletal muscle. Also, we confirmed that the generated power exceeded the power consumption of the electrical stimulation on the skeletal muscle. Hence, we concluded the results showed the feasibility of the energy harvesting system with proposed mechanism.

Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps.

Plasma skimming is the phenomenon whereby the discharge hematocrit is lower than feed hematocrit naturally occurring in the microvessels with Poiseuille flow. It has been studied in Poiseuille flow extensively. Besides, plasma skimming has also been observed and investigated in blood pumps due to its potential to prevent hemolysis by skimming blood cells out of the small gap. However, whether plasma skimming occurs in blood pumps with whole blood has not been verified. Additionally, the independent influence of rotational speed and gap size has not been clarified. Therefore, in order to lay the foundation of applying plasma skimming to the development of blood pumps and also investigate the influence of rotational speed and gap size on plasma skimming respectively, we designed a simplified geometric device which not only imitates the flow inside clearances of blood pumps, but also provides different rotational speed and gap size conditions. We first conducted the verification tests of plasma skimming using whole blood with an initial hematocrit of 44% and the gap size was varied from 10 µm to 240 µm with 10 µm interval. The plasma skimming was verified occurring when the gap was less than 70 µm at a rotational speed of 800 rpm. Since plasma skimming was confirmed, we employed 30% hematocrit blood and performed the following tests to evaluate the influence of rotational speed of 600 rpm, 700 rpm, and 800 rpm respectively. As a result, the hematocrit of sampled blood declined as the rotational speed increased from 600 rpm to 800 rpm. And there was the lowest hematocrit of 16% when the gap was adjusted to 50 µm gap size at 800 rpm. This study further promotes the possibility of applying plasma skimming to the blood pumps with higher hemocapability.

Development of a contactless energy harvesting system driven by contraction of skeletal muscle for implantable medical devices.

We propose a contactless energy harvesting system driven by the contraction of an electrically-stimulated skeletal muscle to be used to supply electrical energy to implantable medical devices. In order to realize a durable generator, the one proposed here has a contactless clutch mechanism with parallel leaf springs, with which the generator can be driven without friction. In this system, the muscle connected to the parallel leaf spring is intentionally contracted by electrical stimulation. The generator can be driven not only in the contraction phase of the muscle, but also relaxation phase. The result an evaluation showed that the prototype could generate 26.1 $\mu \mathrm{W}$ with an efficiency of 13.7%. Finally, we conducted an animal experiment using the gastrocnemius muscle of a toad with a weighing of200 g The generator was driven in the contraction phase generating 1.37 $\mu \mathrm{W}$ of power from the energy supplied by the muscle.

A cost-effective extracorporeal magnetically-levitated centrifugal blood pump employing a disposable magnet-free impeller.

In the field of rotary blood pumps, contactless support of the impeller by a magnetic bearing has been identified as a promising method to reduce blood damage and enhance durability. The authors developed a two-degrees-of-freedom radial controlled magnetic bearing system without a permanent magnet in the impeller in order that a low-cost disposable pump-head for an extracorporeal centrifugal blood pump could be manufactured more easily. Stable levitation and contactless rotation of the 'magnet-free' impeller were realized for a prototype blood-pump that made use of this magnetic bearing. The run-out of the impeller position at between 1000 r/min and 3000 r/min was less than 40 microm in the radial-controlled directions. The total power consumption of the magnetic bearing was less than 1 W at the same rotational speeds. When the pump was operated, a flow rate of 5 l/min against a head pressure of 78.66 kPa was achieved at a rotational speed of 4000 r/min, which is sufficient for extracorporeal circulation support. The proposed technology offers the advantage of low-cost mass production of disposable pump heads.