RESUMO
PIP: 25 fertile women aged 25-36 with an average of 3 children were tested over 93 cycles to observe the effects of synthetic steroids on the neutrophil alkaline phosphatase. The women were using 3 different types of oral contraceptives: Anovlar, Lyndiol, and Enovid-E. 14 women using Anovlar were analyzed for 50 cycles and showed fluctuation in alkaline phosphatase activity with higher levels as compared to normal cycles before the use of Anovlar. 8 women receiving Lyndiol over 18 cycles indicated a low-rise, while 3 women on Enovid-E over 10 cycles showed a rise in alkaline phosphatase activity, but not as much as with the Anovlar. After a 5-cycle follow-up, 5 women who discontinued the pill showed a drop in alkaline scores. After pill discontinuation, there was a gradual return to the neutrophil alkaline phosphatase activity, but these levels did not indicate a correlation with the total leukocyte or absolute neutrophil count.^ieng
