RESUMO
Pre-eclampsia occurs in 2-5% of pregnancies of healthy women. Here, we present a rare case of pre-eclampsia with overt acute heart failure, which was the primary manifestation of systemic lupus erythematosus with cardiac and renal involvement.
Assuntos
Insuficiência Cardíaca/diagnóstico , Recém-Nascido Prematuro , Lúpus Eritematoso Sistêmico/diagnóstico , Pré-Eclâmpsia/diagnóstico , Resultado da Gravidez , Doença Aguda , Adulto , Biópsia por Agulha , Diagnóstico Diferencial , Ecocardiografia Doppler , Feminino , Humanos , Imuno-Histoquímica , Recém-Nascido , Idade Materna , Paridade , Período Pós-Parto , Gravidez , Medição de Risco , Índice de Gravidade de DoençaRESUMO
The role of chemokine-matrix interactions in integrin-dependent T-cell migration was examined to address the critical question of how chemokines provide directional information. The chemokine SDF-1 alpha binds fibronectin (Fn) with a low nanomolar K(d) (equilibrium dissociation constant). SDF-1 alpha presented by Fn induced directed migration. Spatial concentration gradients of chemokine were not required to maintain directed migration. Fn-presented chemokine induced the polarization of cells, including the redistribution of the SDF-1 alpha receptor, to the basal surface and leading edge of the cell. A new model for directed migration is proposed in which the co-presentation of an adhesive matrix and chemokine provides the necessary positional information independent of a soluble spatial gradient. (Blood. 2000;96:2682-2690)
