Development of a library of 6-arylcoumarins as candidate fluorescent sensors.

[structure: see text]. A bromocoumarin scaffold (1) was reacted with various boronic acid derivatives (2a-l) to afford a library of 6-arylcoumarins (3a-l). This library was found to contain candidate fluorescent sensors for peptidase activity and for nitric oxide.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

Synthesis and biological evaluation of an arylsulfonamide class of gamma-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.