Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 8 de 8
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Emerg Infect Dis ; 29(8)2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37486266

RESUMO

Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock and wildlife. Infection with C. ulcerans can cause respiratory or nonrespiratory symptoms in patients. Recently, the microorganism has been increasingly recognized as an emerging zoonotic agent of diphtheria-like illness in Japan. To clarify the overall clinical characteristics, treatment-related factors, and outcomes of C. ulcerans infection, we analyzed 34 cases of C. ulcerans that occurred in Japan during 2001-2020. During 2010-2020, the incidence rate of C. ulcerans infection increased markedly, and the overall mortality rate was 5.9%. It is recommended that adults be vaccinated with diphtheria toxoid vaccine to prevent the spread of this infection.


Assuntos
Infecções por Corynebacterium , Corynebacterium diphtheriae , Difteria , Adulto , Humanos , Difteria/epidemiologia , Difteria/prevenção & controle , Difteria/diagnóstico , Japão/epidemiologia , Corynebacterium/genética , Infecções por Corynebacterium/microbiologia , Toxina Diftérica , Toxoide Diftérico
3.
Am J Otolaryngol ; 26(5): 351-2, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16137537

RESUMO

We report a case of capillary hemangioma of the tympanic membrane in a 51-year-old man with conductive hearing loss, otalgia, and otorrhea. On examination, the external auditory canal was obstructed with a hard, dark red tumor, and purulent discharge was observed. The infection was controlled with antibiotics, but hearing loss persisted. Therefore, transcanal resection was performed. The tumor was attached to the postero-superior quadrant, and arose from the lamina propria. Histologically, the tumor was composed of multiple capillary-sized vessels surrounded by fibrous connective tissue and diagnosed as capillary hemangioma. After surgical treatment, hearing loss was diminished, and there has not been any sign of recurrence for 3 years despite the positive surgical margin.


Assuntos
Neoplasias da Orelha/diagnóstico , Hemangioma Capilar/diagnóstico , Membrana Timpânica/cirurgia , Otorreia de Líquido Cefalorraquidiano/etiologia , Neoplasias da Orelha/cirurgia , Dor de Orelha/etiologia , Perda Auditiva Condutiva/etiologia , Hemangioma Capilar/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade
5.
Auris Nasus Larynx ; 30(2): 169-74, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12753989

RESUMO

OBJECTIVE: Papillary thyroid carcinomas often metastasize to regional lymph nodes, but the significance of lymph node metastasis as a prognostic factor has not been established. This study was conducted to determine the survival rate in patients with and without large lymph node metastasis greater than 3 cm in the maximum diameter, which are N2 or N3 for other head and neck cancers. METHODS: The survival rate was determined by using Kaplan-Meier method in 67 patients with previously untreated papillary thyroid carcinoma who underwent radical surgery at the Department of Otolaryngology, Toyooka Hospital, between 1993 and 2000. RESULTS: The prognosis was significantly poor (P=0.004) in patients with large lymph node metastasis greater than 3 cm in the maximum diameter. No significant difference was noted in the prevalence of large lymph node metastasis greater than 3 cm in the maximum diameter between different T groups. CONCLUSION: Large lymph node metastasis was considered to be a poor prognostic factor of papillary thyroid carcinoma independent of the T classification.


Assuntos
Carcinoma Papilar/mortalidade , Metástase Linfática/patologia , Neoplasias da Glândula Tireoide/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Papilar/patologia , Carcinoma Papilar/terapia , Feminino , Humanos , Linfonodos/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Taxa de Sobrevida , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/terapia
6.
Pathol Int ; 52(7): 438-41, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12167101

RESUMO

Although the prognosis is generally good for patients with papillary thyroid carcinoma, gross nodal metastasis of carcinoma has a poor prognosis. It is necessary to clarify how carcinoma progresses to gross nodal metastasis in order to establish a cure. The adhesion molecule integrin beta-4 is considered to be related to cell migration and metastasis in many carcinomas. In the present study, we examined integrin beta-4 expression in 65 cases of human papillary thyroid carcinoma using immunohistochemical methods. Expression of integrin beta-4 was found in all papillary carcinomas, but in few normal thyrocytes. Interestingly, integrin beta-4 expression in the carcinomas with gross (> or =3 cm) lymph node metastasis was significantly higher than that in carcinomas with small (<3 cm) or no lymph node metastasis. These results suggest that integrin beta-4 expression in thyroid carcinoma may play a role in the development of gross lymph node metastasis of papillary carcinomas.


Assuntos
Carcinoma Papilar/metabolismo , Integrina beta4/biossíntese , Neoplasias da Glândula Tireoide/metabolismo , Carcinoma Papilar/patologia , Humanos , Imuno-Histoquímica , Metástase Linfática/patologia , Prognóstico , Neoplasias da Glândula Tireoide/patologia
7.
Arch Otolaryngol Head Neck Surg ; 128(4): 365-7, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11926908

RESUMO

OBJECTIVE: To assess the efficacy of corticosteroid therapy for sudden-onset sensorineural hearing loss at lower frequencies. DESIGN: Retrospective, nonrandomized, controlled study. PATIENTS AND METHODS: The recovery rate, recovery/improvement rate, and period between the start of therapy and improvement of symptoms were studied in 2 groups: the control group, consisting of 36 patients treated with adenosine triphosphate disodium, kallidinogenase, and cyanocobalamin between March 1, 2000, and January 31, 2001; and the corticosteroid-treated group, consisting of 42 patients treated with corticosteroids in addition to the previously mentioned drugs between April 1, 1997, and February 29, 2000. RESULTS: No significant difference (P =.83) was noted in the recovery rate between the control group (81%) and the corticosteroid-treated group (79%), and the recovery/improvement rate was the same for the 2 groups (83%). In addition, there was no significant difference (P =.84) for the mean +/- SD period between the start of therapy and improvement of symptoms between the control group (3.9 +/- 2.7 days) and the corticosteroid-treated group (3.7 +/- 2.1 days). CONCLUSION: Corticosteroids were not effective for sudden-onset sensorineural hearing loss at lower frequencies.


Assuntos
Glucocorticoides/uso terapêutico , Perda Auditiva Súbita/tratamento farmacológico , Prednisolona/análogos & derivados , Prednisolona/uso terapêutico , Feminino , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
8.
Auris Nasus Larynx ; 29(1): 95-7, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11772500

RESUMO

Hemangiopericytomas are uncommon neoplasms of vascular origin, and rarely arise in the pharynx. We report a case of a 78-year-old female with hemangiopericytoma in her soft palate exhibiting prominent radiosensitivity. Hemangiopericytomas are considered to be radioresistant and wide local excision is a treatment of choice, but their nature is widely variable. In treating aggressive hemangiopericytomas, radiation therapy can be selected.


Assuntos
Hemangiopericitoma/radioterapia , Neoplasias Palatinas/radioterapia , Palato Mole/efeitos da radiação , Idoso , Feminino , Hemangiopericitoma/diagnóstico por imagem , Hemangiopericitoma/patologia , Humanos , Neoplasias Palatinas/diagnóstico por imagem , Neoplasias Palatinas/patologia , Palato Mole/diagnóstico por imagem , Palato Mole/patologia , Tolerância a Radiação , Tomografia Computadorizada por Raios X
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...