RESUMO
There is evidence that transmission of serum hepatitis is associated with transmission of virus-like particles, approximately, 20 millimicron in diameter, containing the Australia or serum hepatitis (SH) antigen, which is currently referred to as the hepatitis associated antigen (HAA). Virus-like particles containing HAA were in the following materials, inoculation of which produced serum hepatitis: (1) a pool of human plasma, (2) serum obtained during the acute phase of hepatitis from a recipient of the plasma pool, (3) a preparation of human thrombin, and (4) serum from a proved hepatitis carrier. The HAA appeared in the serum samples of 61 individuals inoculated with these materials; serum hepatitis developed in 38 of them. Inoculation of dilutions of the plasma pool showed that serum hepatitis can be transmitted by materials containing HAA in amounts too low to be detected by current techniques.
Assuntos
Hepatite B/história , Portador Sadio/sangue , Portador Sadio/virologia , Hepatite B/sangue , Hepatite B/transmissão , Antígenos da Hepatite B/história , Antígenos da Hepatite B/isolamento & purificação , Vírus da Hepatite B/isolamento & purificação , História do Século XX , Humanos , Trombina/imunologiaAssuntos
Adenocarcinoma/induzido quimicamente , Neoplasias da Mama/tratamento farmacológico , Neoplasias Primárias Múltiplas/induzido quimicamente , Tamoxifeno/efeitos adversos , Neoplasias Uterinas/induzido quimicamente , Adenocarcinoma/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Humanos , Cuidados Paliativos , Tamoxifeno/uso terapêuticoRESUMO
Reported are three siblings, a sister and 2 brothers, who had breast cancer. The paternal grandmother of the proband was known to have had breast cancer. It is our belief that this report supports further the genetic etiology of certain breast cancers. The study examines the literature with regard to genetically transmitted female breast cancer and also implies a genetic etiology of male breast cancer. Of special interest is the fact that the female sibling had bilateral breast cancer during her premenopausal years and that one of the two brothers also developed his lesion at an early age, 41 years.
