RESUMO
The associations between retinal findings and haematological parameters in acute leukaemia are controversial. Sixty-three newly-diagnosed acute leukaemia patients, aged 12-77 years, were studied prospectively for the presence of intra-retinal haemorrhages (IRH), white-centred haemorrhages (WCH), cotton wool spots (CWS) and macular haemorrhages (MH), Thirty-three patients (52.4%) showed at least one retinal abnormality. The prevalence of individual findings was: IRH (30 cases), WCH (20 cases), CWS (5 cases), MH (11 cases). In contrast to previous studies, there was no association between any of these retinal findings and the haemoglobin level or the platelet count. There was a higher median WBC in patients with IRH (68 x 10(9)/l) than in those without IRH (15.4 x 10(9)/l), P = 0.037. When the acute myeloblastic leukaemia cases were considered separately, an association was also found between higher WBC and the presence of WCH and CWS. There was no association between retinal findings and FAB type in the AML cases. We conclude that a high WBC may be at least as important as anaemia and thrombocytopenia in the pathogenesis of the retinopathy of acute leukaemia.
Assuntos
Leucemia/patologia , Contagem de Leucócitos , Retina/patologia , Hemorragia Retiniana/etiologia , Vasos Retinianos/patologia , Doença Aguda , Adulto , Idoso , Anemia/etiologia , Viscosidade Sanguínea , Criança , Feminino , Hemoglobinas/análise , Humanos , Leucemia/sangue , Leucemia/classificação , Leucemia/complicações , Leucemia Mieloide/sangue , Leucemia Mieloide/complicações , Leucemia Mieloide/patologia , Infiltração Leucêmica , Macula Lutea/patologia , Masculino , Pessoa de Meia-Idade , Células Neoplásicas Circulantes , Estudos Prospectivos , Hemorragia Retiniana/patologia , Esplenomegalia/etiologiaRESUMO
A family demonstrating autosomal dominant thrombocytopenia is described. A 28-year-old Malay housewife was found to have a platelet count of 40 x 10(9)/l with a low mean platelet volume (6.8 fl) while being investigated prior to ovarian cystectomy. The bone marrow was consistent with immune thrombocytopenia but she failed to respond to appropriate therapy. Five siblings, one parent and one nephew have easy bruising and platelet counts of 39-82 x 10(9)/l. Platelet aggregation studies excluded a major functional defect. Survival of homologous platelets in the circulation was normal. Familial thrombocytopenias are rare but important to differentiate from the common acquired thrombocytopenias in order to spare the patient unnecessary treatments.
