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2.
Artigo em Inglês | MEDLINE | ID: mdl-36865704

RESUMO

Objective: We evaluated the impact of an asymptomatic bacteriuria (ASB) assessment protocol on the number of antibiotics prescribed for ASB after discharge from the emergency department (ED). Design: Single-center, before-and-after, retrospective cohort study. Setting: The study was conducted at a large community health system in North Carolina. Patients: Eligible patients were discharged from an ED without an antibiotic prescription and had a positive urine culture result after discharge from May through July 2021 (preimplementation group) and October through December 2021 (postimplementation group). Methods: Patient records were reviewed to determine the number of antibiotic prescriptions for ASB on follow-up call before and after implementation of an ASB assessment protocol. Secondary outcomes included 30-day admissions, 30-day ED visits, 30-day UTI-related encounters, and projected antibiotic days of therapy. Results: The study included 263 patients: 147 in the preimplementation group and 116 in the postimplementation group). There were significantly fewer antibiotic prescriptions for ASB in the postimplementation group (50% vs 87%; P < .0001). There were no differences in the incidence of 30-day admissions (7% vs 8%; P = .9761), 30-day ED visits (14% vs 16%; P = .7805), or 30-day UTI-related encounters (0% vs 0%, NA). Conclusions: Implementation of an ASB assessment protocol for patients discharged from the ED significantly reduced the number of antibiotic prescriptions for ASB on follow-up call without an increase in 30-day admissions, ED visits, or UTI-related encounters.

3.
Pharmacotherapy ; 43(1): 96-99, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36401791

RESUMO

Neonatal sepsis remains a high cause of morbidity and mortality in preterm neonates. Methicillin-susceptible Staphylococcus aureus (MSSA) can cause persistent bloodstream infections and invasive disease in neonates. We report the first published case of persistent MSSA bacteremia in a preterm neonate successfully treated with oxacillin and ertapenem combination therapy.


Assuntos
Bacteriemia , Staphylococcus aureus Resistente à Meticilina , Osteomielite , Infecções Estafilocócicas , Recém-Nascido , Humanos , Oxacilina/uso terapêutico , Staphylococcus aureus , Ertapenem , Antibacterianos/uso terapêutico , Meticilina/farmacologia , Meticilina/uso terapêutico , Infecções Estafilocócicas/tratamento farmacológico , Osteomielite/tratamento farmacológico , Bacteriemia/tratamento farmacológico
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