[Dynamics of hemodynamic parameters in the early neonatal period]. / Dynamika niektorých hemodynamických parametrov vo vcasnom novorodeneckom období.

BACKGROUND: The fetal circulation is subdued to alteration after birth. Fetal vascular communications enclose (ductus arteriosus Botalli and foramen ovale) and vascular resistance of the lungs and pressure in the pulmonary artery decrease. Low-resistance placenta is excluded from the systemic circuit, leading thus to abrupt pressure elevation and to its further increase. OBJECTIVES: The aim of the study is to judge the dynamics of alterations during the postnatal period by means of Doppler's echocardiography:--the left ventricular ventricle,--parameters characterizing circulation in the pulmonary bed. METHODS: 23 healthy randomly selected newborn infants born at full term were examined on the 1st and 2nd day of their life. RESULTS: Parameters of the left ventricular function did not change between the 1st and 2nd days of life. Parameters from the outflow tract of the right ventricle on the 5th day of life of infants: the ratio of PEP (preejection period) to AT (acceleration time) significantly decreased, the ratio of PEP to ET(ejection time) did not change. Parameters of the pulmonary artery on the 5th day of life of infants: significant decrease of the ratio PEP/AT, as well as of PEP/ET, the peak and mean velocity of blood flow significantly increased. CONCLUSIONS: The left ventricular function is not subdued to alterations during early postnatal period. The parameters characterizing the pulmonary circulation prove a decrease of pressure in the pulmonary bed on the 5th day of life. MEANING FOR PRACTICE AND THEORY: The results are utilizable in interpretation of echocardiographic examination in postnatal age. (Fig. 8, Ref. 19.).

[Cerebrovascular blood flow velocity in a healthy neonate in the first days of life]. / Rýchlost' prietoku krvi mozgom zdravého novorodenca v prvých dnoch zivota.

The authors examined the rate of cerebral blood flow in 60 mature neonates during the first 6 days of life. The infants had a negative perinatal and postnatal history, satisfactory post-partum adaptation and a normal objective finding. For assessment ultrasound was used-Aloka SD 680 with a coloured pulsed Doppler. The authors assessed velocity in the anterior cerebral artery and in the middle cerebral artery. The results were recorded in curves giving mean values +/- SD. The authors evaluated maximal systolic and diastolic velocity, the mean rate and the index of resistance. A more marked decline of the resistance index was recorded on the second day of life. The different velocities had a continuous rising trend. Results of other authors are discussed.

[Treatment of a patent duct in neonates]. / Liecba otvoreného duktu v novorodeneckom veku.

The authors analyze clinical and laboratory aspects of Indomethacin treatment of neonates with a patent ductus arteriosus. From June 1987 to November 1990 the authors treated 19 neonates with a patent ductus arteriosus with Indomethacin. The drug was administered, 0.1-0.3 mg/kg body weight, by the oral route three times/24 or 36 hours. In 17 infants after Indomethacin treatment the duct closed, in two infants the duct did not close during Indomethacin treatment, in three infants the authors observed oliguria which improved after discontinuation of treatment.