A Case of Improved Refractory Uveitis in Behcet's Disease after Infliximab Therapy / 대한류마티스학회지

Behcet's disease is a multisystemic, chronic relapsing inflammatory disease characterized by vasculitides, mucocutaneous lesions, thrombophlebitis, arthritis. Among them, the ocular involvement is usual (50~70%) and the most serious morbidity is blindness (20~25% of those of affected). Immunosuppressive treatment is currently the main therapy in chronic relapsing uveitis, but many patients experience recurrent sight-threatening uveitis. T lymphocytes play an important role in the pathogenesis of uveitis by releasing cytokines such as tumor necrosis factor (TNF) alpha. There are some reports that the anti-TNFalpha treatment is effective in refractory Behcet's uveitis, but it has not been reported in Korea. We report a case of refractory uveitis in Behcet's disease which is improved after anti-TNFalpha therapy.

A Case of Idiopathic Orbital Myositis

Idiopathic orbital myositis, a subgroup of previously so called inflammatory orbital pseudotumor, occurred with acute onset periorbital pain, eyelid swelling, proptosis, and ophthalmoplegia. Currently many pathologist and ophthalmologist agreed the term pseudotumor or Tolosa-Hunt syndrome and They classified some cases as characterized histologic and computerized tomographic evidence of inflammation of extraocular muscles, good responsiveness to prednisone, remission and exacerbation, with recurrence, but generally benign condition. The possibility of idiopathic orbital myositis being an immune-mediated process has been discussed. Some believe many of such cases have been grouped under the term Tolosa-Hunt syndrome. It is onloy in the last decade that computerized tomographic scanning has allowed precise localization of the alterations to orbital and retro-orbital strcutures. The term idopathic orbital myositis is precise insofar as it indicates the structures primarily involved ocular muscles. We report a case of idiopathic orbital myositis withr review of literatures.