Fractional Flow Reserve Cardio-Oncology Effects on Inpatient Mortality, Length of Stay, and Cost Based on Malignancy Type: Machine Learning Supported Nationally Representative Case-Control Study of 30 Million Hospitalizations.

Background and Objectives: There are no nationally representative studies of mortality and cost effectiveness for fractional flow reserve (FFR) guided percutaneous coronary interventions (PCI) in patients with cancer. Our study aims to show how this patient population may benefit from FFR-guided PCI. Materials and Methods: Propensity score matched analysis and backward propagation neural network machine learning supported multivariable regression was performed for inpatient mortality in this case-control study of the 2016 National Inpatient Sample (NIS). Regression results were adjusted for age, race, income, geographic region, metastases, mortality risk, and the likelihood of undergoing FFR versus non-FFR PCI. All analyses were adjusted for the complex survey design to produce nationally representative estimates. Results: Of the 30,195,722 hospitalized patients meeting criteria, 3.37% of the PCIs performed included FFR. In propensity score adjusted multivariable regression, FFR versus non-FFR PCI significantly reduced inpatient mortality (OR 0.47, 95%CI 0.35−0.63; p < 0.001) and length of stay (LOS) (in days; beta −0.23, 95%CI −0.37−−0.09; p = 0.001) while increasing cost (in USD; beta $5708.63, 95%CI, 3042.70−8374.57; p < 0.001), without significantly increasing complications overall. FFR versus non-FFR PCI did not specifically change cancer patients' inpatient mortality, LOS, or cost. However, FFR versus non-FFR PCI significantly increased inpatient mortality for Hodgkin's lymphoma (OR 52.48, 95%CI 7.16−384.53; p < 0.001) and rectal cancer (OR 24.38, 95%CI 2.24−265.73; p = 0.009). Conclusions: FFR-guided PCI may be safely utilized in patients with cancer as it does not significantly increase inpatient mortality, complications, and LOS. These findings support the need for an increased utilization of FFR-guided PCI and further studies to evaluate its long-term impact.

Unstable Cervical Spine Fracture in a Surfer Presenting as Concussion With Associated Low Grade Neck Pain: A Case Report.

OBJECTIVE: The purpose of this study is to describe the evaluation and management of a surfer who presented with concussion-like symptoms and was eventually diagnosed with an unstable cervical spine fracture. CLINICAL FEATURES: A young man presented to a chiropractic clinic 5 weeks after a surfing injury. He had mild lower cervical spine pain and complaints of cognitive disturbance. He was previously evaluated by his primary care provider who diagnosed cervical sprain and strain injuries. There was no prior imaging or follow-up concussion management. INTERVENTION AND OUTCOME: After a history, exams were performed of the cervical spine, thoracic spine, shoulder, and head, including a modified Sport Concussion Assessment Tool, Third Edition, concussion evaluation. Cervical spine radiographs were taken, which demonstrated a right C6 pillar fracture grade 2 anterior spondylolisthesis. These findings were confirmed with a CT scan. The patient was referred to an orthopedic spine specialist for further consultation, which resulted in cervical fusion of the C6/7 motor unit. CONCLUSION: The use of clinical guidelines for head and neck injury assisted in the appropriate management of this patient with cervical spine injury presenting with concussion symptoms.