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1.
Int Angiol ; 34(3): 263-8, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25877427

RESUMO

AIM: The aim of this paper is to report on the hemodynamic significance of the various degrees reflux as demonstrated on descending phlebography, by comparing the phlebographic findings with ambulatory venous pressure (AVP) measurements. METHOD: Thirty-two patients (45 affected limbs) with active or healed venous ulceration were admitted to the study. Descending phlebography with grading of reflux (0-4 using Herman's grading), AVP and refilling time 90 (RT90) were performed in all patients. In addition, the presence of deep to superficial reflux into the great saphenous vein at the sapheno-femoral junction, thigh incompetent perforating veins, small saphenous vein at the saphenopopliteal junction and incompetent calf perforating veins was recorded using ascending functional phlebography. The examined limbs were separated into two groups according to the Grade of reflux. Group I consisted of limbs in which popliteal valve incompetence was not demonstrated on descending phlebography, i.e., Grades 0-2 (18 limbs). Group II consisted of limbs with popliteal reflux as demonstrated by descending venography, i.e., grades 3 and 4 (27 limbs). RESULTS: In Group I the mean AVP ± SD was 47.2 ± 9.3 mmHg (range 31-67 mmHg). After the application of the ankle tourniquet to exclude the effects of the superficial venous incompetence on the pressure recordings, the mean AVP ± SD became 28.1 ± 9.9 mmHg (range 11-44) (paired t test: P < 0.001). In Group II (limbs with incompetent popliteal valves) the mean AVP ± SD was 71.6 ± 12.7 mmHg (range 49-95 mmHg) before the tourniquet. This was significantly higher than in Group I (t test: P < 0.001). The application of the ankle tourniquet in this group produced a small but significant decrease in the AVP (mean AVP ± SD: 66 ± 14.5 mmHg) (paired t test: P < 0.001). CONCLUSION: Incompetence of the femoral valves in the presence of competent popliteal valves adds very little to the hemodynamic abnormality produced by superficial venous reflux. In the majority of these patients, there is co-existing reflux from deep to superficial veins with associated superficial valve incompetence which is responsible for the venous hypertension, skin changes and ulceration. The hemodynamic changes which in the past had been associated with deep venous insufficiency (AVP >45 mmHg and RT90 < 14 seconds despite the application of an ankle tourniquet) occur only when there is popliteal incompetence.


Assuntos
Hemodinâmica , Extremidade Inferior/irrigação sanguínea , Úlcera Varicosa/fisiopatologia , Insuficiência Venosa/fisiopatologia , Pressão Venosa , Adulto , Idoso , Feminino , Veia Femoral , Humanos , Masculino , Pessoa de Meia-Idade , Flebografia , Veia Safena/fisiopatologia
2.
Acta Chir Belg ; 108(6): 660-5, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19241914

RESUMO

UNLABELLED: To know the future one must look to the past. AIM: To review the history of sclerotherapy and the application of duplex ultrasound guided foam sclerotherapy (UFS) to the treatment of varicose veins. METHOD: The development of sclerotherapy in the treatment of varicose veins during the last century is described with the introduction of ultrasound guided foam sclerotherapy during the last decade. Foam sclerotherapy is described and the possible side effects are discussed. No long-term (10 years) random trial results are yet available. CONCLUSION: Ultrasound guided foam sclerotherapy is a useful technique in the management of chronic venous disease.


Assuntos
Escleroterapia/métodos , Ultrassonografia Doppler Dupla , Varizes/terapia , Doença Crônica , Humanos , Soluções Esclerosantes/administração & dosagem , Escleroterapia/instrumentação , Úlcera Varicosa/terapia
3.
Int J Clin Pract ; 59(10): 1195-203, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16178988

RESUMO

Vulval varices and perivulval veins are common though often unrecognised, and pelvic pain is a common complaint, sometimes without an obvious cause, hence treatment is not always successful. An association between these two problems has long been established, and some cases of pelvic pain are clearly associated with venous pathology. Often, these patients present to the vein clinic with recurrent varicose veins, because the standard procedures have failed and the pelvic origin was not recognised. The understanding of the pathology has evolved and will be reviewed. To establish diagnosis, the communication from the atypical varicose veins in the legs to the ovarian veins must be shown and incompetence of one or both ovarian veins must be demonstrated. Treatment requires elimination of the retrograde flow in the ovarian veins. This can be by either surgical ligation and removal or obliteration with coils and sclerosant. Having removed the cause and relieved the pelvic symptoms, the leg veins can then be successfully treated.


Assuntos
Ovário/irrigação sanguínea , Pelve/irrigação sanguínea , Varizes/diagnóstico , Insuficiência Venosa/complicações , Feminino , Humanos , Dor Pélvica/etiologia , Síndrome , Varizes/etiologia , Insuficiência Venosa/diagnóstico , Insuficiência Venosa/terapia
4.
J Virol ; 73(8): 7077-9, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10400813

RESUMO

Primary cultures of human umbilical vein endothelial cells (HUVEC) express the human coxsackievirus and adenovirus receptor (HCAR). Whereas HCAR expression in HeLa cells was constant with respect to cell density, HCAR expression in HUVEC increased with culture confluence. HCAR expression in HUVEC was not quantitatively altered by infection with coxsackievirus B.


Assuntos
Adenoviridae/metabolismo , Enterovirus/metabolismo , Receptores Virais/biossíntese , Contagem de Células , Células Cultivadas , Proteína de Membrana Semelhante a Receptor de Coxsackie e Adenovirus , Endotélio Vascular/citologia , Endotélio Vascular/metabolismo , Células HeLa , Humanos , Veias Umbilicais
7.
Surgery ; 111(4): 402-8, 1992 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-1557686

RESUMO

Three theories have been proposed to explain the cause of varicose veins, citing three different factors as the primary cause: valvular incompetence, a weakness of the vein wall, and increased arterial inflow associated with multiple arteriovenous communications. This study was designed to determine the cause of varicose veins with respect to these three factors. Duplex scanning techniques were used to assess the venous valves, and simultaneous measurements of calf volume (strain-gauge plethysmography) and venous pressure made during venous occlusion plethysmography were used to determine the elasticity of the venous wall and the rate of arterial inflow. Fifty-one control legs and 36 legs with superficial venous insufficiency were examined. Risk factors were used to divide the control legs into two groups: low risk or normal (23 legs) and high risk (28 legs). The results obtained in the high-risk limbs demonstrated a significantly reduced vein wall elasticity (p less than 0.001) and increased arterial inflow (p less than 0.005) compared with the normal limbs, with no corresponding increase in the incidence of valvular incompetence. These results clearly suggest that the role of the venous valves in the development of varicose veins is secondary to changes in the elastic properties of the vein wall and the rate of arterial inflow.


Assuntos
Varizes/fisiopatologia , Veias/fisiopatologia , Elasticidade , Humanos , Músculo Liso Vascular/diagnóstico por imagem , Músculo Liso Vascular/fisiopatologia , Pletismografia , Valores de Referência , Fatores de Risco , Ultrassonografia , Varizes/diagnóstico por imagem , Varizes/etiologia , Veias/diagnóstico por imagem
9.
Br J Surg ; 78(5): 625-9, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-2059821

RESUMO

A total of 149 consecutive unselected patients (221 limbs) who presented with signs and symptoms of chronic venous problems (varicose veins with or without ankle oedema, skin changes and leg ulcers) have been studied by clinical examination, ascending deep to superficial venography, Doppler ultrasound and ambulatory venous pressure measurements. Of the limbs, 180 (82 per cent) had varicose veins without obstruction in the deep veins or reflux in the popliteal or femoral veins while 41 (18 per cent) had deep venous disease. Of the 180 limbs with 'primary' varicose veins 110 (60 per cent) did not have incompetent calf perforating veins (group A) while 70 (40 per cent) did (group B). On the basis of the ambulatory venous pressure after calf muscle exercise and the refilling time, the incompetent calf perforating veins of limbs in group B belonged to three subgroups of different haemodynamic significance. In 20 limbs (30 per cent) they were found to be of no haemodynamic significance, in 25 (35 per cent) of moderate haemodynamic significance and in 25 (35 per cent) of major haemodynamic significance. The last were, on clinical examination, indistinguishable from limbs with deep venous disease although they had patent deep veins with competent popliteal valves.


Assuntos
Perna (Membro)/irrigação sanguínea , Varizes/fisiopatologia , Insuficiência Venosa/fisiopatologia , Humanos , Flebografia , Veia Poplítea/diagnóstico por imagem , Veia Safena/diagnóstico por imagem , Ultrassonografia , Varizes/complicações , Varizes/diagnóstico por imagem , Insuficiência Venosa/complicações , Insuficiência Venosa/diagnóstico por imagem , Pressão Venosa
10.
Br J Hosp Med ; 43(3): 200-6, 1990 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2180521

RESUMO

Perivulval varices appear during pregnancy and usually disappear after delivery but become more prominent with subsequent pregnancies. They may extend over the buttock and may be associated with recurrent leg varices. Some patients have extensive varices in the broad ligaments and present with the pelvic congestion syndrome. These patients have been shown to have grossly dilated ovarian veins. Elimination of this proximal incompetence relieves the symptoms.


Assuntos
Ovário/irrigação sanguínea , Pelve/irrigação sanguínea , Varizes , Feminino , Humanos , Gravidez , Síndrome
11.
Br J Surg ; 76(9): 929-32, 1989 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-2679965

RESUMO

Surgery of the short saphenous vein is associated with a high recurrence rate because of variations in the anatomy or inadequate clinical examination. To prevent this, accurate definition of the pattern and level of termination of the saphenopopliteal junction and flush ligation is necessary. Clinical examination, Doppler ultrasound, duplex scanning and peroperative venography have been compared to assess the level of termination of the short saphenous vein. In all, 64 limbs of 46 patients were examined. In 39 limbs there was primary short saphenous incompetence, in 13 limbs there was recurrent short saphenous incompetence; in ten of these there was incompetence of the gastrocnemius vein. In 12 limbs a duplex scan did not demonstrate incompetence of the short saphenous vein or gastrocnemius vein. The accuracy of these methods when locating incompetence of the short saphenous vein to within 2 cm of the saphenopopliteal junction was 56 per cent for clinical examination, 64 per cent for Doppler ultrasound and 96 per cent for duplex scanning. When there was no saphenopopliteal junction (9 per cent), duplex scanning correctly detected the pattern of the incompetent vein. The apparent success of clinical examination was because the vein was not felt above the femoral intercondylar groove and 52 per cent of the veins terminated at this level. Duplex scanning is a non-invasive technique which is almost as accurate as venography and provides additional haemodynamic information about the incompetent veins by demonstrating the presence and extent of reflux.


Assuntos
Veia Safena/patologia , Insuficiência Venosa/diagnóstico , Feminino , Humanos , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Radiografia , Veia Safena/diagnóstico por imagem , Veia Safena/cirurgia , Ultrassonografia , Insuficiência Venosa/diagnóstico por imagem , Insuficiência Venosa/cirurgia
12.
Br J Surg ; 76(6): 577-80, 1989 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2758262

RESUMO

A reduction in the 'elasticity' of the venous system has been proposed as a precursor of venous insufficiency, but the concept remains controversial. This study was designed to develop a method of assessing venous elasticity, and to use this method to investigate the aetiology of varicose veins. Simultaneous measurements of calf volume (determined using strain gauge plethysmography) and venous pressure (obtained via a dorsal foot vein) were made during venous occlusion plethysmography. The elastic modulus, K, defined as stress/strain when the veins are full, was calculated from the pressure/volume relationship. The elastic modulus was determined in 19 normal legs, 33 legs with superficial venous insufficiency, 16 legs with deep venous insufficiency, and 18 legs of a high risk group of volunteers or patients without varicose veins but with a strong history of factors associated with their development. The results showed a clear difference in elasticity between normal limbs and limbs with varicose veins, and also between normal limbs and high risk limbs. These results support the hypothesis that reduced elasticity has a role in the development of varicose veins and precedes the onset of valvular incompetence.


Assuntos
Varizes/etiologia , Elasticidade , Humanos , Perna (Membro)/irrigação sanguínea , Pletismografia , Pressão , Fatores de Risco , Varizes/fisiopatologia , Veias/fisiopatologia
13.
Br J Hosp Med ; 41(3): 299, 1989 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2713584
16.
J Cardiovasc Surg (Torino) ; 27(2): 169-74, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3512574

RESUMO

Doppler Ultrasound is now routinely used to demonstrate valvular reflux in the venous system. Incompetence detected at the back of the knee is located either in the short saphenous vein or in the popliteal vein. Whether the incompetence is in the deep or superficial venous system can be differentiated by digital compression over the short saphenous vein in the upper calf; if reflux is abolished then the incompetence is assumed to be in the superficial vein but if it is not prevented it must be in the popliteal vein. Sometimes the reflux is not controlled when the deep system is normal. This has been shown to be due to variations in the anatomy of the short saphenous vein and especially the pattern of its termination. Examples with venography are given, showing that in the presence of incompetence at the sapheno-popliteal junction there may be no reflux in the short saphenous vein; instead the proximal tributaries are involved and reflux in these veins is not controlled by pressure over the short saphenous vein. This explains the false positive diagnosis of valvular incompetence in the popliteal vein.


Assuntos
Veia Poplítea , Veia Safena , Ultrassonografia , Insuficiência Venosa/diagnóstico , Adulto , Diagnóstico Diferencial , Erros de Diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Veia Poplítea/diagnóstico por imagem , Radiografia , Veia Safena/diagnóstico por imagem
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