RESUMO
This study cross-validates reported changes in behavioural and event-related potential (ERP) correlates of prospective memory (PM) inhibitory control performance applying different PM response selection demands (Bisiacchi et al., 2009). Participants were randomly assigned to a control group condition with no PM requirement, or to either inhibit ongoing task processing to respond to PM task cues (task-switch; TS) or provide an ongoing task response prior to providing a PM button press (dual-task; DT). The behavioural data indicated that ongoing task reaction time (RT) performance was similar in the DT, TS, and control group conditions. PM cue detection mechanisms reflected by the N300 did not differ between PM tasks. However, early occurring (400-700 ms) PM late parietal complex (LPC) amplitudes recorded over anterior electrode sites were larger in the TS compared to the DT-PM condition, and this difference persisted during the 700-1000 ms epoch. Thus, ERP correlates of PM task-set remapping were significantly altered via the induction of different PM response production rules retrieved from retrospective memory (RM). The enhancement of anteriorly distributed TS LPC amplitudes between 400 and 700 ms led to the suggestion that increased inhibition in this group condition was accompanied by heightened frontally mediated neural activations that support prepotent ongoing task response inhibition processing.
Assuntos
Memória Episódica , Sinais (Psicologia) , Potenciais Evocados , Humanos , Tempo de Reação , Estudos RetrospectivosRESUMO
AIM: To test the hypothesis that a 'basal plus' regimen--adding once-daily main-meal fast-acting insulin to basal insulin once daily--would be non-inferior to biphasic insulin twice daily as assessed by glycated haemoglobin (HbA1c) concentration (predefined as ≤0.4%), but would provide superior treatment satisfaction. METHODS: This open-label trial enrolled adults to an 8- or 12-week run-in period, during which oral therapies except metformin were stopped and insulin glargine dose was titrated. Those with fasting glucose <7 mmol/l but HbA1c >7% (53 mmol/mol) were randomized to insulin glargine/glulisine once daily (n = 170) or insulin aspart/aspart protamine 30/70 twice daily (n = 165) for 24 weeks, with dose titration to glucose targets using standardized algorithms. RESULTS: For HbA1c, the basal plus regimen was non-inferior to biphasic insulin (least squares mean difference, 0.21%, upper 97.5% confidence limit 0.38%) meeting the predefined non-inferiority margin of 0.4%. Treatment satisfaction (Diabetes Treatment Satisfaction Questionnaire change version and Insulin Treatment Satisfaction Questionnaire total scores) significantly favoured basal plus. No difference was observed between the basal plus and the biphasic insulin groups in responders (HbA1c <7%, 20.6 vs 27.9%; p = 0.12), weight gain (2.06 vs 2.50 kg; p = 0.2), diabetes-specific quality of life (Audit of Diabetes-Dependent Quality of Life average weighted impact (AWI) score) and generic health status (five-dimension European Quality of Life questionnaire). Overall hypoglycaemia rates were similar between groups (15.3 vs 18.2 events/patient-year; p = 0.22); nocturnal hypoglycaemia was higher with the basal plus regimen (5.7 vs 3.6 events/patient-year; p = 0.02). CONCLUSION: In long-standing type 2 diabetes with suboptimal glycaemia despite oral therapies and basal insulin, the basal plus regimen was non-inferior to biphasic insulin for biomedical outcomes, with a similar overall hypoglycaemia rate but more nocturnal events.
Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Hiperglicemia/prevenção & controle , Hipoglicemia/prevenção & controle , Hipoglicemiantes/uso terapêutico , Insulina Glargina/uso terapêutico , Insulina/análogos & derivados , Idoso , Austrália/epidemiologia , Insulinas Bifásicas/administração & dosagem , Insulinas Bifásicas/efeitos adversos , Insulinas Bifásicas/uso terapêutico , Automonitorização da Glicemia , Diabetes Mellitus Tipo 2/sangue , Esquema de Medicação , Combinação de Medicamentos , Quimioterapia Combinada/efeitos adversos , Feminino , Hemoglobinas Glicadas/análise , Humanos , Hiperglicemia/epidemiologia , Hipoglicemia/induzido quimicamente , Hipoglicemia/epidemiologia , Hipoglicemiantes/administração & dosagem , Hipoglicemiantes/efeitos adversos , Incidência , Insulina/administração & dosagem , Insulina/efeitos adversos , Insulina/uso terapêutico , Insulina Aspart/administração & dosagem , Insulina Aspart/efeitos adversos , Insulina Aspart/uso terapêutico , Insulina Glargina/administração & dosagem , Insulina Glargina/efeitos adversos , Insulina Isófana/administração & dosagem , Insulina Isófana/efeitos adversos , Insulina Isófana/uso terapêutico , Análise de Intenção de Tratamento , Masculino , Pessoa de Meia-Idade , Pacientes Desistentes do Tratamento , Qualidade de Vida , Reino Unido/epidemiologiaRESUMO
BACKGROUND: Quantitative evidence on the strength of the association between abdominal obesity and the incidence of type 2 diabetes was assessed. METHODS: Systematic review of longitudinal studies assessing the relationship between measures reflecting abdominal obesity and the incidence of type 2 diabetes. RESULTS: There was a strong association between measures reflecting abdominal obesity and the incidence of type 2 diabetes, the pooled odds ratio was 2.14 (95% CI: 1.70-2.71; p < 0.0001). Waist circumference (WC) was at least as good as other measures in predicting outcome. CONCLUSIONS: There is a strong association between measures reflecting abdominal obesity and the development of type 2 diabetes. Reducing WC may reduce the risk of developing type 2 diabetes.
Assuntos
Diabetes Mellitus Tipo 2/etiologia , Obesidade/complicações , Gordura Abdominal/patologia , Adulto , Idoso , Diabetes Mellitus Tipo 2/patologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Obesidade/patologia , Fatores de Risco , Circunferência da CinturaRESUMO
We examined the feasibility of a low-cost, store-and-forward teledermatology service for general practitioners (GPs) in regional Queensland. Digital pictures and a brief case history were transmitted by email. A service coordinator carried out quality control checks and then forwarded these email messages to a consultant dermatologist. On receiving a clinical response from the dermatologist, the service coordinator returned the message to the referring GP. The aim was to provide advice to rural GPs within one working day. Over six months, 63 referrals were processed by the teledermatology service, covering a wide range of dermatological conditions. In the majority of cases the referring doctors were able to treat the condition after receipt of email advice from the dermatologist; however, in 10 cases (16%) additional images or biopsy results were requested because image quality was inadequate. The average time between a referral being received and clinical advice being provided to the referring GPs was 46 hours. The number of referrals in the present study, 1.05 per month per site, was similar to that reported in other primary care studies. While the use of low-cost digital cameras and public email is feasible, there may be other issues, for example remuneration, which will militate against the widespread introduction of primary care teledermatology in Australia.
Assuntos
Dermatologia/organização & administração , Atenção Primária à Saúde/organização & administração , Consulta Remota/organização & administração , Dermatopatias/diagnóstico , Medicina de Família e Comunidade/organização & administração , Estudos de Viabilidade , Humanos , Queensland , Encaminhamento e Consulta/organização & administraçãoRESUMO
A second-opinion child psychiatry service was piloted for six months in the northern-most two-thirds of Queensland. It provided specialist expertise by telehealth to local multidisciplinary teams of mental health staff. During the study period, 28 videoconferences were performed by the service: nine for administrative purposes, two for educational purposes, and 17 for direct and indirect clinical applications. The mean time between a referral being made and a consultation being performed was 4.7 days (range 1-13). A survey administered to referring and non-referring mental health workers showed that the major barriers to service implementation included the limited allied health applications that were offered, a perceived lack of communication during the implementation phase of the service, and the creation of a new referral network that did not conform to traditional referral patterns in the north of Queensland.
Assuntos
Psiquiatria Infantil/organização & administração , Serviços de Saúde Mental/organização & administração , Consulta Remota/métodos , Criança , Feminino , Pesquisa sobre Serviços de Saúde , Humanos , Masculino , Projetos Piloto , Queensland , Encaminhamento e Consulta/organização & administração , Comunicação por VideoconferênciaRESUMO
BACKGROUND: Rett syndrome is a neurological disorder, almost exclusively affecting girls. METHODOLOGY: Between 1993 and 1995 pedigree data were obtained from families of girls registered with the Australian Rett syndrome database. RESULTS: Although 21 individual disorders were reported to be present in family members of affected girls, there was no apparent clustering of the same disorder in different families. However it was certain that a geneticist had been involved in only 10.9% of cases. CONCLUSIONS: Mutations in the MECP2 gene have now been reported in a proportion of sporadic cases. Thus, it will be important to examine this phenotype-genotype correlation in the Australian cohort. Where a mutation is found, prenatal diagnosis in a subsequent pregnancy will be a possibility. Using the Australian population database and in conjunction with the clinical genetic services in each state it is planned to contact families with an affected girl to offer testing and counselling.
Assuntos
Síndrome de Rett/genética , Criança , Pré-Escolar , Feminino , Expressão Gênica/genética , Aconselhamento Genético , Ligação Genética , Predisposição Genética para Doença , Humanos , Linhagem , Mutação Puntual/genética , GravidezRESUMO
X-linked ocular albinism (OA1), Nettleship-Falls type, is characterized by decreased ocular pigmentation, foveal hypoplasia, nystagmus, photodysphoria, and reduced visual acuity. Affected males usually demonstrate melanin macroglobules on skin biopsy. We now report results of deletion and mutation screening of the full-length OA1 gene in 29 unrelated North American and Australian X-linked ocular albinism (OA) probands, including five with additional, nonocular phenotypic abnormalities (Schnur et al. 1994). We detected 13 intragenic gene deletions, including 3 of exon 1, 2 of exon 2, 2 of exon 4, and 6 others, which span exons 2-8. Eight new missense mutations were identified, which cluster within exons 1, 2, 3, and 6 in conserved and/or putative transmembrane domains of the protein. There was also a splice acceptor-site mutation, a nonsense mutation, a single base deletion, and a previously reported 17-bp exon 1 deletion. All patients with nonocular phenotypic abnormalities had detectable mutations. In summary, 26 (approximately 90%) of 29 probands had detectable alterations of OA1, thus confirming that OA1 is the major locus for X-linked OA.
Assuntos
Albinismo Ocular/genética , Proteínas do Olho/genética , Deleção de Genes , Glicoproteínas de Membrana/genética , Cromossomo X , Análise Mutacional de DNA , Feminino , Ligação Genética , Humanos , Masculino , Mutação , Análise de SequênciaRESUMO
Van Hippel-Lindau disease (VHL) is an autosomal dominantly inherited disorder, characterised by the development of clear cell renal carcinomas, CNS hemangioblastomas, retinal angiomas, pancreatic tumors, pheochromocytomas and hepatic cysts. Recently a number of families with dominant familial pheochromocytoma as the only clinical manifestation have been reported to carry mutations in the HVL gene. We describe a family in which a novel VHL S68W mutation was segregating and carrier individuals manifested with variable penetrance of isolated pheochromocytomas. Investigation of this kindred confirmed that a mutation in the VHL gene could produce isolated pheochromocytomas as the only clinical feature and was variably penetrant.
Assuntos
Ligases , Mutação/genética , Penetrância , Feocromocitoma/genética , Proteínas/genética , Proteínas Supressoras de Tumor , Ubiquitina-Proteína Ligases , Doença de von Hippel-Lindau/genética , Genes Supressores de Tumor/genética , Humanos , Proteína Supressora de Tumor Von Hippel-LindauRESUMO
Normal individuals express the two alternative transcripts, FMR2 and Ox19, from the FRAXE-associated CpG island. Molecular analysis of the Ox19 transcript suggests that it is a truncated isoform of the FMR2 gene with an alternative 3' end. Both isoforms showed a similar pattern of expression, with the Ox19 isoform expressed at a much lower level. Fibroblasts, chorionic villi and hair roots showed the highest level of FMR2 expression, whole blood cells and amniocytes showed very low expression, and the transcript was not detected in lymphoblasts. Fibroblasts of 11 individuals from seven families segregating FRAXE were assayed for FMR2 expression and FRAXE CpG island methylation. A man with an unmethylated expansion of 0.6 kb expressed FMR2 and represents a pre-mutation carrier. All chromosomes with FRAXE CCG expansions of 0.8 kb or greater were fully methylated and did not express the FMR2 gene, analogous to the mechanism of silencing the FMR1 gene in carriers of the FRAXA full mutation. The boundary between FRAXE pre-mutation and FRAXE full mutation is between 0.7 and 0.8 kb. Two men with absence of FMR2 expression in fibroblasts were not mentally impaired, suggesting that IQ in some men with FRAXE full mutation may remain within the normal range. Although molecular tools to study FRAXE non-specific mental retardation are now available, further psychometric and molecular studies are needed to characterize the effect of the FRAXE full mutation for the purpose of genetic counselling.
Assuntos
Ilhas de CpG/genética , Síndrome do Cromossomo X Frágil/genética , Proteínas Nucleares , Proteínas/genética , Proteínas de Ligação a RNA , Transativadores , Sequência de Bases , Northern Blotting , Southern Blotting , Células Cultivadas , Metilação de DNA , Primers do DNA/química , Primers do DNA/genética , Mecanismo Genético de Compensação de Dose , Eletroforese em Gel de Poliacrilamida , Feminino , Fluorescência , Proteína do X Frágil da Deficiência Intelectual , Expressão Gênica , Triagem de Portadores Genéticos , Humanos , Testes de Inteligência , Masculino , Proteínas de Membrana/química , Proteínas de Membrana/genética , Proteínas de Membrana/metabolismo , Dados de Sequência Molecular , Proteínas do Tecido Nervoso/genética , Reação em Cadeia da Polimerase , Polimorfismo Genético/genética , RNA Mensageiro/genética , Análise de Sequência , Deleção de Sequência/genéticaRESUMO
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN 1) is a tumour predisposition syndrome that usually manifests in the first four decades of life. It has an autosomal dominant mode of inheritance which means that any new member of a MEN1 kindred has roughly a 50% chance of developing the disorder during their lifetime. The localisation of the MEN1 gene to a small region of chromosome band 11q13 has led to the development of DNA-based predictive diagnosis for this disease. AIMS: To establish a polymerase chain reaction (PCR)-based system, using simple tandem repeat polymorphisms (STRPs), to predict gene carriers in four Australian MEN 1 kindreds. METHODS: Six STRP markers flanking the MEN1 region of chromosome band 11q13 were used to screen individuals for a common haplotype in order to determine carrier status. RESULTS: The accuracy of prediction was calculated to be > 95% in informative individuals. CONCLUSIONS: DNA-based presymptomatic detection of affected members of MEN 1 kindreds could facilitate their care and reduce the inconvenience and expense of repeated testing of unaffected members. However, due to occasional recombination events or uninformativeness of markers in certain individuals, carrier status cannot always be predicted.
Assuntos
Triagem de Portadores Genéticos/métodos , Neoplasia Endócrina Múltipla Tipo 1/genética , Reação em Cadeia da Polimerase , Sequências Repetitivas de Ácido Nucleico , Adulto , Autorradiografia , Cromossomos Humanos Par 11/genética , Feminino , Haplótipos , Humanos , Linhagem , Sequências Repetitivas de Ácido Nucleico/genéticaAssuntos
Anormalidades Múltiplas/induzido quimicamente , Anormalidades Múltiplas/genética , Anticonvulsivantes/efeitos adversos , Doenças em Gêmeos , Ácido Valproico/efeitos adversos , Adulto , Epilepsia/complicações , Epilepsia/tratamento farmacológico , Feminino , Humanos , Recém-Nascido , Masculino , Troca Materno-Fetal , Linhagem , Gravidez , Complicações na Gravidez/tratamento farmacológico , Gêmeos DizigóticosRESUMO
One hundred nineteen individuals from 11 families with X-linked ocular albinism (OA1) were studied with respect to both their clinical phenotypes and their linkage genotypes. In a four-generation Australian family, two affected males and an obligatory carrier lacked cutaneous melanin macroglobules (MMGs); ocular features were identical to those of Nettleship-Falls OA1. Four other families had more unusual phenotypic features in addition to OA1. All OA1 families were genotyped at DXS16, DXS85, DXS143, STS, and DXS452 and for a CA-repeat polymorphism at the Kallmann syndrome locus (KAL). Separate two-point linkage analyses were performed for the following: group A, six families with biopsy-proved MMGs in at least one affected male; group B, four families whose biopsy status was not known; and group C, OA-9 only (16 samples), the family without MMGs. At the set of loci closest to OA1, there is no clear evidence in our data set for locus heterogeneity between groups A and C or among the four other families with complex phenotypes. Combined multipoint analysis (LINKMAP) in the 11 families and analysis of individual recombination events confirms that the major locus for OA1 resides within the DXS85-DXS143 interval. We suggest that more detailed clinical evaluations of OA1 individuals and families should be performed for future correlation with specific mutations in candidate OA1 genes.
Assuntos
Albinismo Ocular/genética , Cromossomo X , Albinismo Ocular/patologia , Mapeamento Cromossômico/métodos , Feminino , Fundo de Olho , Expressão Gênica , Triagem de Portadores Genéticos , Ligação Genética , Variação Genética , Genótipo , Humanos , Síndrome de Kallmann/genética , Masculino , Melanócitos , Linhagem , Fenótipo , Polimorfismo de Fragmento de Restrição , Recombinação Genética , Aberrações dos Cromossomos Sexuais , Pele/patologiaRESUMO
We present data on 10 patients from 5 families with a condition of microcephaly, intracranial calcification, and a clinical course resembling congenital TORCH infection. Repeatedly, negative TORCH investigations are a prerequisite for the identification of this disorder and the value of disturbed liver function and thrombocytopenia as aids to diagnosis is emphasised. Several similar families with recurrence of the disease in sibships are identified in the literature and the genetic implications of our observations are considered.
Assuntos
Encefalopatias/genética , Calcinose/genética , Doenças do Sistema Nervoso Central/genética , Microcefalia/genética , Encéfalo/diagnóstico por imagem , Pré-Escolar , Infecções por Citomegalovirus/congênito , Feminino , Genes Recessivos , Infecções por Herpesviridae/congênito , Humanos , Lactente , Recém-Nascido , Masculino , Linhagem , Tomografia Computadorizada por Raios X , Toxoplasmose Congênita/diagnósticoRESUMO
The features of a 32 year old woman with Ehlers-Danlos syndrome type VIIB and affected members of her family, resulting from a mutation in one COL1A2 allele, were studied. Her dermal type I collagen contained alpha 2(I) chains and mutant pN-alpha 2(I) chains in which the amino-terminal propeptide remained attached to the alpha 2(I) chain. She was heterozygous for an AG-->AC mutation at the splice acceptor site of intron 5 of the COL1A2 gene. The mutation activated a cryptic AG splice acceptor site corresponding to positions +14 and +15 of exon 6 of the COL1A2 gene. In contrast to previous reports only five, rather than all 18, amino acids encoded by exon 6 were deleted in the proband. The deleted peptide removed the amino-proteinase cleavage site, but not the nearby lysine cross linking site in the amino-telopeptide of the alpha 2(I) chain. She was born with bilateral hip dislocations, knee subluxations, and generalised joint hypermobility. Bilateral inguinal herniae and an umbilical hernia were present at birth. Facial features included a depressed nasal bridge with prominent paranasal folds. The skin was soft, moderately hyperelastic, and sagged over the face. Skin fragility and easy bruising were apparent from childhood. Skin wounds healed slowly and with broad, paper thin scars. Throughout her life, she had multiple fractures of the small bones of her hands and feet following moderate trauma. Electron microscopy of the proband's dermis as well as deep fascia and hip joint capsule from her affected brother showed that collagen fibrils in transverse section were nearly circular but with irregular margins. Light microscopy of bone from her affected brother and son showed normal Haversian systems and lamellar bone. All of these tissues contained approximately equal amounts of the normal and mutant alpha2(I) chains. The findings of this study confirm that loss of the amino-proteinase cleavage site of the pro alpha2(I) collagen chains, owing to anomalous splicing of exon 6 sequences in the conversion of pre-mRNA to mRNA, produces the clinical features of Ehlers-Danlos syndrome type VIIB. The history of frequent fractures found in this family is atypical and indicates an overlap with osteogenesis imperfecta.
Assuntos
Colágeno/genética , Síndrome de Ehlers-Danlos/patologia , Íntrons , Mutação Puntual , Splicing de RNA , Adulto , Síndrome de Ehlers-Danlos/classificação , Síndrome de Ehlers-Danlos/genética , Éxons , Feminino , Fraturas Ósseas/genética , Heterozigoto , Humanos , Articulações/patologia , Masculino , Microscopia Eletrônica , Osteogênese Imperfeita/genética , Linhagem , Fenótipo , Pele/patologiaRESUMO
One hundred eighteen cases of nevoid basal cell carcinoma syndrome (NBCCS, Gorlin's syndrome or basal cell nevus syndrome) are presented in this study. In aiming to ascertain all the affected families in Australia, we have examined the largest series to date. Relative frequencies of associated complications are presented and compared with those of the recent English survey by Evans et al. [J Med Genet 30:460-464, 1993]. The frequencies of most manifestations are similar. However, one major difference is that the multiple basal cell carcinomas are manifest from an earlier age in the Australian population, which probably reflects greater exposure to ultraviolet radiation. Of the 64 families ascertained, 37 represented simplex cases, and, accordingly, the apparent new mutation rate is surprisingly high (14-81%) given the lack of impact of NBCCS on reproductive capabilities. There is some evidence to suggest that this may be attributable to anticipation.
Assuntos
Síndrome do Nevo Basocelular , Anormalidades Múltiplas/genética , Adolescente , Adulto , Idade de Início , Alelos , Austrália/epidemiologia , Síndrome do Nevo Basocelular/diagnóstico , Síndrome do Nevo Basocelular/epidemiologia , Síndrome do Nevo Basocelular/genética , Osso e Ossos/anormalidades , Calcinose/genética , Criança , Pré-Escolar , Mapeamento Cromossômico , Cromossomos Humanos Par 9 , Dura-Máter/patologia , Feminino , Ligação Genética , Testes Genéticos , Humanos , Lactente , Doenças Maxilomandibulares/genética , Ceratodermia Palmar e Plantar/genética , Masculino , Pessoa de Meia-Idade , Mutação , Nova Zelândia/epidemiologia , Cistos Odontogênicos/genética , Palato/anormalidades , Fenótipo , Prevalência , País de Gales/epidemiologiaRESUMO
We present a case of rhizomelic dwarfism with clinical, radiographic and histologic features in keeping with atelosteogenesis type III (spondylohumerofemoral hypoplasia). Unlike most other skeletal chondrodysplasias presenting with neonatal dwarfism, a proportion of patients with atelosteogenesis type III may survive well beyond the neonatal period, and hence early identification of the condition is important. Our surviving patient further defines the radiographic features of the condition and the natural history and prognosis for physical and intellectual disability.
Assuntos
Doenças do Desenvolvimento Ósseo , Doenças do Desenvolvimento Ósseo/diagnóstico por imagem , Doenças do Desenvolvimento Ósseo/patologia , Nanismo/diagnóstico por imagem , Nanismo/patologia , Feminino , Humanos , Recém-Nascido , Radiografia , SíndromeRESUMO
Nevoid basal cell carcinoma syndrome (NBCCS; basal cell nevus syndrome or Gorlin syndrome) is a cancer-predisposition syndrome characterized by multiple basal cell carcinomas (BCCs) and diverse developmental defects. The gene for NBCCS has been mapped to 9q23.1-q31 in North American and European families. In addition, loss of heterozygosity (LOH) for genetic markers in this region has been detected in sporadic BCCs, indicating that the NBCCS gene is probably a tumor-suppressor gene. In this study we have determined that the NBCCS gene is also linked to this region in Australasian pedigrees and that there is no significant evidence of heterogeneity. We have defined the localization of the gene by multipoint and haplotype analysis of 15 families, using four microsatellite markers. LOH at these loci was detected in 50% of sporadic BCCs, a rate that is significantly higher than that in other skin lesions used as controls.
Assuntos
Síndrome do Nevo Basocelular/genética , Cromossomos Humanos Par 9 , Adulto , Austrália , Mapeamento Cromossômico/métodos , DNA Satélite/análise , Feminino , Deleção de Genes , Genes Supressores de Tumor , Ligação Genética , Marcadores Genéticos , Heterozigoto , Humanos , Escore Lod , Masculino , Nova Zelândia , LinhagemRESUMO
In a case-control study of all cerebral palsy cases with moderate and severe spastic quadriplegia born between 1976 and 1985, males comprised three-quarters of the cases and tended to have more severe motor impairment than females. The majority of cases had multiple and severe disabilities, and 27 per cent had died by the time of data collection. There was an excess of low-birthweight and preterm births compared with all live births in WA. An intrapartum cause was considered possible in 18 of the 74 children; however, half of these had evidence of compromise before labour.