1.
Angew Chem Int Ed Engl
; 40(21): 4055-4060, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12404491
2.
Angew Chem Int Ed Engl
; 40(21): 4055-4060, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29712249
RESUMO
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthesis, which exploits boron-mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.