RESUMO
Patients with benign gastric ulcer were treated for four weeks with carbenoxolone sodium as Biogastrone tablets 100 mg three times a day, and if the ulcers were not healed at 4 weeks treatment was continued for a further 4 weeks. Fifty two patients entered the trial, and 12 were withdrawn. In 17 patients who were randomly allotted double-blind additional dummy tablets 16 of their ulcer healed completely endoscopically, whereas of the 23 patients given additional amiloride 5 mg three times a day only 14 ulcers healed, a significant reduction in ulcer healing. The clinical (weight gain and oedema) and metabolic (hypertension, hypokalaemia and hypernatraemia) side-effects were reduced by the active amiloride therapy, but serum carbenoxolone levels were not affected. Thus the potassium-retaining diuretic amiloride, like the aldosterone antagonist spironolactone, markedly reduces both the ulcer-healing and the metabolic side-effects of carbenoxolone sodium, and should not be used together with it in the treatment of peptic ulcer.
Assuntos
Amilorida/farmacologia , Carbenoxolona/uso terapêutico , Ácido Glicirretínico/análogos & derivados , Pirazinas/farmacologia , Úlcera Gástrica/tratamento farmacológico , Adulto , Amilorida/efeitos adversos , Pressão Sanguínea/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Carbenoxolona/antagonistas & inibidores , Carbenoxolona/metabolismo , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Distribuição Aleatória , Úlcera Gástrica/metabolismoRESUMO
In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer.
Assuntos
Amilopectina/uso terapêutico , Úlcera Duodenal/tratamento farmacológico , Ensaios Clínicos como Assunto , Método Duplo-Cego , Humanos , MasculinoRESUMO
An antibody against ruminant (goat, sheep, bovine) IgM is described which also cross-reacts with rabbit IgM. The antibody was found in the serum of a patient with adult coeliac disease and a selective IgA deficiency. This patient gave a false high Rose-Waaler rheumatoid factor titre due to the presence of the serum antibody to rabbit IgM that was capable of agglutinating rabbit antibody-sensitised erythrocytes.
Assuntos
Anticorpos Anti-Idiotípicos , Reações Cruzadas , Imunoglobulina M , Fator Reumatoide/análise , Animais , Anticorpos Anti-Idiotípicos/análise , Bovinos , Doença Celíaca/imunologia , Reações Falso-Positivas , Feminino , Cabras , Humanos , Imunoglobulina M/imunologia , Pessoa de Meia-Idade , Coelhos , OvinosAssuntos
Anti-Inflamatórios/efeitos adversos , Úlcera Duodenal/tratamento farmacológico , Hemorragia Gastrointestinal/induzido quimicamente , Propionatos/efeitos adversos , Idoso , Artrite Reumatoide/tratamento farmacológico , Compostos de Benzil/efeitos adversos , Humanos , Masculino , Doenças Reumáticas/tratamento farmacológicoRESUMO
The motor responses of the proximal colon, sigmoid, and rectum to the ingestion of a standard meal have been compared in patients with total gastrectomy, pernicious anaemia, or duodenal ulcer. Colonic pressure activity increased during and after food in all the patients, but this was only once associated with propulsive activity. The results suggest that the postprandial pressure activity in the sigmoid colon is greater after total gastrectomy than in the other two groups. It is concluded that entry of food into the upper small intestine is the most important factor in initiating the colonic pressure response to food, since this response does not require the presence of the stomach, acid, antral gastrin, or of vagal innervation.
Assuntos
Anemia Perniciosa/fisiopatologia , Colo/fisiopatologia , Úlcera Duodenal/fisiopatologia , Gastrectomia , Motilidade Gastrointestinal , Adulto , Idoso , Colo Sigmoide/fisiopatologia , Sistema Digestório/diagnóstico por imagem , Feminino , Alimentos , Suco Gástrico/metabolismo , Mucosa Gástrica/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Pressão , Radiografia , Reto/fisiopatologia , TelemetriaRESUMO
Propulsive activity of the human colon was measured with radiopaque markers (shapes), radiotelemetering capsules, Perspex capsules containing (51)Cr, or with free (51)Cr sodium chromate. Propulsive activity can be readily detected by these techniques, none of which requires the use of radiological contrast media. With capsules containing (51)Cr or with free (51)Cr repeated observations can be made in the same patient without recourse to radiography. The patient can remain normally active during the test with encapsulated (51)Cr. Repeated observations may also be made with shapes, if films exposed at low mA are used. It was found that colonic intraluminal pressure activity rises markedly during and after food, but that in the resting patient this increase is rarely associated with propulsive activity. In physically active patients propulsion of colonic contents was significantly increased after meals. When colonic propulsion takes place, it does so by a series of mass movements. These results suggest that somatic activity is an important factor in the control of colonic transit in health or disease.
Assuntos
Colo/fisiologia , Motilidade Gastrointestinal , Adulto , Idoso , Isótopos do Cromo , Colo/diagnóstico por imagem , Colo/fisiopatologia , Doenças Funcionais do Colo/fisiopatologia , Feminino , Alimentos , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica/fisiopatologia , Esforço Físico , Pressão , Radiografia , Cintilografia , TelemetriaRESUMO
The effect of intravenous infusion of gastrin II on gastric and colonic motor activity was studied in 12 patients; gastric acid output was also measured. Administration of gastrin at near-maximal dose levels stimulates the motor activity of the antrum but has no measurable effect on the activity of the proximal colon, sigmoid, or rectum. The results suggest that gastrin plays a part in the regulation of gastric motility but that it is not a mediator of the gastro-colic reflex.
