Stage I corpus cancer: is teletherapy necessary?

OBJECTIVE: Our aim was to evaluate the perioperative morbidity after hysterectomy and lymphadenectomy as primary treatment of endometrial cancer and to analyze the recurrence and survival of patients classified as having surgical stage I disease who did not receive adjunctive teletherapy. STUDY DESIGN: Over a 10-year interval 444 patients underwent extensive surgical staging for corpus cancer. Perioperative events were recorded prospectively. Outcome events were updated after the last year of study. RESULTS: After patients with high-risk histologic types of cancer were excluded, 396 patients were evaluable. The risk of extrauterine disease, detected in 21.8% of patients, increased with increasing lack of tumor differentiation. The associated surgical morbidity, including blood loss (mean 336 ml), surgical site infection (3.5%), thromboembolic events (1.5%), and urinary injury (0.6%), and deaths (0.6%) did not differ from those in reports of women undergoing lesser operative procedures. Late complications, including lymphocyst (1.2%), leg edema (1.8%), and hernia (2.9%), were infrequent. Recurrence and survival analysis indicated a calculated 5-year survival of 97% of all patients with surgical stage I disease. There was a significant survival difference related to grade and stage for women in whom disease was confined to the uterus. Overall survival in patients with stage IA (100%) was significantly different (p < 0.0001) from that of patients with stage IB (97%) and stage IC (93%). All recurrences included a distal component. CONCLUSION: Extensive surgical staging including lymphadenectomy can be performed safely. Our results suggest that the risk of pelvic recurrence is not increased and the risk of survival is not compromised in those women not receiving adjunctive teletherapy.

Radical hysterectomy: does the type of incision matter?

OBJECTIVE: Our purpose was to evaluate and compare aspects of operative accessibility and perioperative outcome after radical hysterectomy and pelvic lymphadenectomy performed through a vertical, Pfannenstiel, or Maylard abdominal incision. STUDY DESIGN: During an 8-year interval, 236 patients underwent radical hysterectomy and pelvic lymphadenectomy as primary treatment for cervical cancer at the Watson Clinic. Patients were admitted under a standard perioperative protocol, and all procedures were performed by a gynecologic oncologist. All clinical data was recorded prospectively and updated regularly. RESULTS: Radical hysterectomy and pelvic lymphadenectomy was completed through a vertical (n = 113), Pfannenstiel (n = 78), or Maylard (n = 45) incision. Although lesion size and depth of stromal invasion was not different between incision types, patients with a Pfannenstiel incision were younger (p < 0.001) and weighed less than those with a vertical (p = 0.001) or Maylard (p < 0.025) incision. The Pfannenstiel was associated with a shorter operative time (Pfannenstiel vs Maylard, p < 0.05; Pfannenstiel vs vertical, p < 0.001), less blood loss (Pfannenstiel vs Maylard, p < 0.025; Pfannenstiel vs vertical, p < 0.001), a lower risk of transfusion, and a shorter hospital stay (Pfannenstiel vs Maylard, p < 0.025; Pfannenstiel vs vertical, p < 0.001). These differences persisted when controlled for patient weight and surgical experience. There was no significant difference in the total number of nodes evaluated. No patient had a positive vaginal margin. CONCLUSION: Radical hysterectomy and pelvic lymphadenectomy can be safely performed through a vertical, Maylard, or Pfannenstiel incision. In a selected population a Pfannenstiel incision offers the potential benefit of less abdominal wall trauma without compromising surgical exposure or increasing the risk of surgical complications.

The efficacy and safety of the cytobrush during pregnancy.

The safety and efficacy of abrasive cytology, using the cytobrush, were evaluated in 300 pregnant patients. When compared to conventional cytology obtained with a cotton-tipped applicator there was no difference in adverse pregnancy events. Smear adequacy (containing endocervical cells) was statistically (P less than 0.01) and clinically increased from 21 to 86%. The use of abrasive cervical cytology was associated with a twofold increase in the incidence of abnormal smears.

Surgical staging of uterine cancer: an analysis of perioperative morbidity.

Surgical staging documented extrauterine disease in 27.9% of 168 patients with apparent early-clinical-stage uterine cancer. An analysis of operative time (78 +/- 21 min), blood loss (332 +/- 160 cc), and surgical site infection risks (4.7%) indicated little additional risk of lymphadenectomy. The long-term risk of lymphocyst (1.3%) or lymphedema (0.7%) was small. The histologic information obtained from staging was utilized to rationally guide the need for adjunctive teletherapy. The overall risk of recurrence (median follow-up, 26 months) with surgical Stage I disease was 2.6%.

Vaginal adenocarcinoma developing in residual pelvic endometriosis: a clinical dilemma.

The clinical history of a patient with pelvic adenocarcinoma arising in residual endometriosis is reported. Detailed literature review fails to outline an optimal treatment strategy; however, thoughts concerning staging and treatment are presented.