Voluntary exercise attenuates nociceptive abnormalities with no significant alterations of social interaction deficits in the BTBR mouse model of autism.

Due to the financial burden and undesired side effects of treatment options, researchers have begun exploring alternative methods of treating autism spectrum disorder (ASD). Based on research suggesting impressive health benefits of engaging in physical activity, exercise treatment to alleviate symptoms could be a more cost effective alternative to pharmaceutical interventions. This study examined the effects of physical exercise on nociceptive responses and social interactions in an autism mouse model (BTBR T+ Itpr3tf/J). Subjects (n = 32) were separated into groups (BTBR vs B6 controls) based on the genetic strain and activity condition they were assigned. When compared to B6 controls, the BTBR mice demonstrated thermal hypoalgesia that normalized following 5 weeks of voluntary wheel running. However, exercise did not significantly attenuate social interaction deficits in BTBR mice, despite scores trending toward a positive direction. These results suggest that exercise could serve as a potential additive to other therapies for abnormal nociception in individuals with Autism Spectrum Disorder.

Validity of Wearable Activity Monitors during Cycling and Resistance Exercise.

INTRODUCTION: The use of wearable activity monitors has seen rapid growth; however, the mode and intensity of exercise could affect the validity of heart rate (HR) and caloric (energy) expenditure (EE) readings. There is a lack of data regarding the validity of wearable activity monitors during graded cycling regimen and a standard resistance exercise. The present study determined the validity of eight monitors for HR compared with an ECG and seven monitors for EE compared with a metabolic analyzer during graded cycling and resistance exercise. METHODS: Fifty subjects (28 women, 22 men) completed separate trials of graded cycling and three sets of four resistance exercises at a 10-repetition-maximum load. Monitors included the following: Apple Watch Series 2, Fitbit Blaze, Fitbit Charge 2, Polar H7, Polar A360, Garmin Vivosmart HR, TomTom Touch, and Bose SoundSport Pulse (BSP) headphones. HR was recorded after each cycling intensity and after each resistance exercise set. EE was recorded after both protocols. Validity was established as having a mean absolute percent error (MAPE) value of ≤10%. RESULTS: The Polar H7 and BSP were valid during both exercise modes (cycling: MAPE = 6.87%, R = 0.79; resistance exercise: MAPE = 6.31%, R = 0.83). During cycling, the Apple Watch Series 2 revealed the greatest HR validity (MAPE = 4.14%, R = 0.80). The BSP revealed the greatest HR accuracy during resistance exercise (MAPE = 6.24%, R = 0.86). Across all devices, as exercise intensity increased, there was greater underestimation of HR. No device was valid for EE during cycling or resistance exercise. CONCLUSIONS: HR from wearable devices differed at different exercise intensities; EE estimates from wearable devices were inaccurate. Wearable devices are not medical devices, and users should be cautious when using these devices for monitoring physiological responses to exercise.

Attention-deficit/hyperactivity disorder medication does not alter exercise-induced hypoalgesia following an acute bout of dynamic circuit resistance exercise.

The primary goal of this study was to investigate the effects of attention-deficit/hyperactivity disorder (ADHD) medications on exercise-induced hypoalgesia (EIH), heart rate, and perceived exertion. Thirty college-age students (10 Controls, 10 ADHD diagnosis, and 10 ADHD diagnosis with medications) completed 2 sessions: 1) a maximal testing session and 2) an experimental session consisting of 3 consecutive dynamic resistance exercise circuits comprised of 12 repetitions of 9 exercises at 60% of 1-repetition maximum using a 1:1 work to rest ratio. All participants, regardless of condition (Controls vs. ADHD without medications vs. ADHD with medications), displayed EIH accompanied by an increase in blood lactate, heart rate, and perceived exertion for the duration of the exercise bout. Therefore, the effects of resistance exercise are not altered by ADHD diagnosis or psychostimulant medication use for ADHD. These findings are intriguing given the known ergogenic and hypoalgesic effects of caffeine, a less potent stimulant.

Exercise-induced hypoalgesia: Pain tolerance, preference and tolerance for exercise intensity, and physiological correlates following dynamic circuit resistance exercise.

Previous research has demonstrated significant decreases in pain perception in healthy individuals following both aerobic and upper body resistance exercise, but research on circuit training has been limited. The purpose of the study was to determine the effects of a strenuous bout of dynamic circuit resistance exercise on pain threshold and pain tolerance in conjunction with changes in blood lactate levels, heart rate (HR), and perceived exertion. A sample of 24 college-age students participated in 2 sessions: (1) a maximal strength testing session and (2) a circuit training bout of exercise that consisted of 3 sets of 12 repetitions with a 1:1 work to rest ratio at 60% one-repetition maximum (1-RM) predicted from a three-repetition maximum (3-RM) for 9 exercises. Participants exhibited increases in pain tolerance, blood lactate levels, HR and perceived exertion following resistance exercise. Preference for exercise intensity was positively correlated with lactate post exercise and tolerance for exercise intensity was positively correlated with pain tolerance and lactate post exercise. In conclusion, this is the first study to demonstrate increases in pain tolerance following a dynamic circuit resistance exercise protocol and disposition for exercise intensity may influence lactate and pain responses to circuit resistance exercise.

Comparison of Resistance Exercise Perceived Exertion and Muscle Activation at Varied Submaximal Durations, Loads, and Muscle Actions.

Hollander, DB, Worley, JR, Asoodeh, M, Wakesa, D, Magnuson, M, Dantzler, DK, Didier, JJ, and Kraemer, RR. Comparison of resistance exercise perceived exertion and muscle activation at varied submaximal durations, loads, and muscle actions. J Strength Cond Res 31(5): 1387-1394, 2017-Previous studies investigating muscle activation from dynamic, plate-loaded, concentric (CON) and eccentric (ECC) muscle contractions have not accounted for the greater absolute strength of ECC contractions. The purpose of the study was to determine the effect of different dynamic muscle contraction durations, loads, and contraction types (CON and ECC) on perceived exertion and muscle activation differences in 6 women (mean ± SD age, height, weight, body mass index 22.83 ± 2.56 years, 1.65 ± 0.261 m, 68.56 ± 2.72 kg, 25.26 ± 4.39 kg·m). The participants were recruited and trained to move weight at the appropriate duration (2, 3, 4, and 5 seconds) for leg extension using a displacement apparatus (sonic emitter, auditory) and a computer program (visual feedback of bar displacement). Concentric and ECC 1 repetition maximum (1RM) were determined for leg extension for the midrange 3-second duration. Thirty, 50, and 70% of either CON or ECC 1RM were loaded for the remainder of the sessions. Subjects were then assigned to complete trials in a counterbalanced fashion for load, contraction type, and contraction duration. Rating of perceived exertion (RPE) significantly increased in response to load (30, 50, and 70%) regardless of contraction type as did electromyography (EMG) root mean square amplitude. Greater time under tension significantly increased RPE regardless of contraction type during knee extension exercise. The EMG amplitude was less distinguishable between 2, 3, 4, and 5 seconds of contractions. The data highlight the effort sense distinctions made by women at submaximal exercise loads during knee extension. These findings should be used to develop effective resistance exercise protocols that facilitate positive perceptions and adherence resistance exercise loads, durations of contraction, and contraction type.

Comparison of two-hand kettlebell exercise and graded treadmill walking: effectiveness as a stimulus for cardiorespiratory fitness.

Prevailing interest in the use of kettlebell (KB) exercises for rehabilitation and improvement of muscular strength has led to several recent studies, some suggesting that KB exercise may be useful for improvement of cardiorespiratory fitness. The purpose of this study was to determine whether KB exercise would produce similar cardiovascular stress to that of walking and thus provide an additional exercise mode for the improvement of cardiorespiratory fitness. It was hypothesized that a moderate-intensity, continuous KB protocol, would produce similar metabolic and cardiorespiratory responses as a brisk bout of graded treadmill (TM) walking, but greater rating of perceived exertion (RPE). Ten novice volunteers (5 men, 5 women) completed a preliminary session to determine body composition and VO2max and to familiarize participants with standardized KB exercise technique. Subsequently, they completed a 30-minute KB session that included 3 continuous 10-minute sets of 10 KB swings followed by 10 sumo deadlifts, with 3-minute rests between 10-minute exercise periods. The third session was a 30-minute TM regimen that began at the walking speed and 4% grade that matched the VO2 from the KB session and included 3-minute rest intervals after 10-minute TM exercise periods. VO2, respiratory exchange ratio, kcal·min, and blood pressure were similar for KB and moderate-intensity TM exercise, but RPE and heart rate were greater during KB exercise. Data indicate that a KB routine consisting of 2-hand swings and sumo deadlifts with 3-minute rest periods produces similar metabolic responses to those of a moderate-intensity TM walking protocol designed for the improvement of aerobic fitness.

Partial occlusion during resistance exercise alters effort sense and pain.

The purpose of the study was to determine how manipulation of peripheral blood flow during resistance exercise using a light load affected perception and physiological measures compared with moderate load resistance exercise and a control trial. Seven subjects performed a 3 (session) by 2 (biceps curls and calf extensions) within-subjects study that was randomized and counterbalanced across 3 weeks. The 3 sessions included (a) light resistance exercise (3 sets to failure) at 30% of 1 repetition maximum (1RM) with partial occlusion (LRO), (b) moderate resistance at 70% of 1RM with no occlusion (MR), and (c) partial occlusion without exercise (OO). Ratings of perceived exertion (RPE), pain, and heart rate were assessed immediately after each set, whereas blood samples were taken before, immediately after, and 15 minutes after exercise. Results demonstrated that RPE and pain were lower in the OO condition than that in the MR and LRO conditions for biceps curls and calf extensions, Fs(2 ,24) = 22.75, 20.86, ps < 0.0001 and Fs(2,24) = 18.95, 24.52, ps < 0.01; however, no significant differences were noted between MR and LRO conditions. Heart rate was significantly higher for the LRO condition when compared with the MR trial, F(2,18) 20.12, p < 0.001. Results suggest that when partial vascular occlusion with a light load was applied, both pain and effort sense were altered to a similar degree as moderate loads but no occlusion. The practical application of results were that individuals may be better able to tolerate perceptual change at low loads with partial occlusion because joint stress may be minimized while local muscle metabolic demands increase, making resistance training maximally effective and minimally stressful on joints. Perceptual tracking of effort and pain may aid coaches who attempt this protocol.

Effects of gender on physiological responses to strenuous circuit resistance exercise and recovery.

Few studies have focused upon the physiological responses to circuit weight training (CWT) in men and women, and an investigation of possible gender differences could lead to optimal exercise prescriptions and improved adaptation outcomes. The purpose of the study was to determine the effects of gender on cardiovascular and metabolic responses to CWT and consequent recovery. Ten healthy men and 10 healthy women completed an initial session to collect descriptive data and determine a 12 repetition maximum (12RM) for 6 different upper- and lower-body resistance exercises. This was followed by 2 identical sessions of a CWT protocol on 2 separate days at least 48 hours apart. The first session was used to familiarize subjects with the equipment and the testing protocol. The second session was used to determine physiological responses. Each subject performed 10 repetitions of 6 exercises for 3 circuits at a 12RM load. Vo2 and respiratory exchange ratio (RER) were continuously monitored, whereas heart rate (HR) and blood pressure (BP) were taken at the end of each circuit. Across the exercise session, men revealed greater absolute and relative Vo2, relative lean body mass Vo2, systolic BP (SBP), RER, and recovery Vo2 when compared with the female subjects. There were no differences in HR, diastolic BP (DBP), or recovery RER. The present study provides a greater insight into gender differences in cardiovascular and metabolic responses to circuit weight training. These gender differences should be taken into consideration for development of CWT protocols for men and women.

Load rather than contraction type influences rate of perceived exertion and pain.

The purpose of the study was to determine whether muscle contraction type (concentric [CON] or eccentric [ECC]) or loading (relative or absolute) has a greater impact on the perceptual and metabolic responses to conventional resistance exercise. Additionally, overall effort, pain sensations, and specific pain descriptors were compared with physiological responses. Seven healthy men (mean +/- SE, 25.71 +/- 2.17 years) with resistance training experience completed 2 one-repetition maximum (1-RM) trials. Subsequently, 2 randomized, counterbalanced, experimental sessions were completed consisting of 4 sets of 10 repetitions for 6 exercises. These sessions were performed at 65% CON 1-RM for CON only contractions or 65% CON 1-RM + 20% for ECC contractions. Blood samples were taken pre, post, and 15 minutes postexercise. OMNI-RPE (OMNI-Res), CR-10 pain rating, McGill pain ratings, and heart rate (HR) were recorded after each set. A significant time effect occurred for OMNI-Res, pain, lactate, and HR (p < 0.05). No significant pattern emerged for the contraction type, except for higher HR and lactate immediately postexercise for the CON contractions. Physiological measures were not significantly related to perceptual measures. When considered with previous data, muscle loading rather than contraction type plays the primary role in perceptual alterations of effort sense and pain. Practical applications of the investigation are that strength and conditioning professionals may be able to load CON and ECC contractions in a relative fashion by increasing loads in the ECC portion by 20% above the CON load that would result in comparable perceptual experiences.

The acute effects of twenty-four hours of sleep loss on the performance of national-caliber male collegiate weightlifters.

Currently, the degree to which sleep loss influences weightlifting performance is unknown. This study compared the effects of 24 hours of sleep loss on weightlifting performance and subjective ratings of psychological states pre-exercise and postexercise in national-caliber male collegiate weightlifters. Nine males performed a maximal weightlifting protocol following 24 hours of sleep loss and a night of normal sleep. The subjects participated in a randomized, counterbalanced design with each sleep condition separated by 7 days. Testosterone and cortisol levels were quantified prior to, immediately after, and 1 hour after the resistance training session. Additionally, profile of mood states and subjective sleepiness were evaluated at the same time points. The resistance training protocol consisted of several sets of snatches, clean and jerks, and front squats. Performance was evaluated as individual exercise volume load, training intensity and overall workout volume load, and training intensity. During each training session the maximum weight lifted for the snatch, clean and jerk, and front squat were noted. No significant differences were found for any of the performance variables. A significant decrease following the sleep condition was noted for cortisol concentration immediately after and 1 hour postexercise. Vigor, fatigue, confusion, total mood disturbance, and sleepiness were all significantly altered by sleep loss. These data suggest that 24 hours of sleep loss has no adverse effects on weightlifting performance. If an athlete is in an acute period of sleep loss, as noticed by negative mood disturbances, it may be more beneficial to focus on the psychological (motivation) rather than the physiological aspect of the sport.

Maximal eccentric and concentric strength discrepancies between young men and women for dynamic resistance exercise.

Although research has demonstrated that isokinetic eccentric (ECC) strength is 20-60% greater than isokinetic concentric (CON) strength, few data exist comparing these strength differences in standard dynamic resistance exercises. The purpose of the study was to determine the difference in maximal dynamic ECC and CON strength for 6 different resistance exercises in young men and women. Ten healthy young men (mean +/- SE, 25.30 +/- 1.34 years), and 10 healthy young women (mean +/- SE, 23.40 +/- 1.37 years) who were regular exercisers with resistance training experience participated in the study. Two sessions were performed to determine CON and ECC 1 repetitions maximum for latissimus pull-down (LTP), leg press (LP), bench press (BP), leg extension (LE), seated military press (MP), and leg curl (LC) exercises. Maximal ECC and maximal CON strength were determined on weight stack machines modified to isolate ECC and CON contractions using steel bars and pulleys such that only 1 type of contraction was performed. Within 2 weeks, participants returned and completed a retest trial in a counterbalanced fashioned. Test-retest reliability was excellent (r = 0.99) for all resistance exercise trials. Men demonstrated 20-60% greater ECC than CON strength (LTP = 32%, LP = 44%, BP = 40%, LE = 35%, MP = 49%, LC = 27%). Women's strength exceeded the proposed parameters for greater ECC strength in 4 exercises, p < 0.05 (LP = 66%, BP = 146%, MP = 161%, LC = 82%). The ECC/CON assessment could help coaches capitalize on muscle strength differences in young men and women during training to aid in program design and injury prevention and to enhance strength development.

Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion.

Previous studies of contracting muscle with low loading and partial vascular occlusion demonstrated hypertrophy and strength adaptations similar to and exceeding those observed with traditional moderate to high resistance (Shinohara M, Kouzaki M, Yoshihisa T, and Fukunaga T. Eur J Physiol 77: 189-191, 1998; Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, and Ishii N. J Appl Physiol 88: 2097-2106, 2000; Takarada Y, Sato Y, and Ishii N. Eur J Physiol 86: 308-314, 2002). The purpose of the study was to determine the anabolic and catabolic hormone responses to light resistance exercise combined with partial vascular occlusion. Three experimental conditions of light resistance with partial occlusion (LRO), moderate resistance with no occlusion (MR), and partial occlusion without exercise (OO) were performed by eight healthy subjects [mean 21 yr (SD 1.8)]. Three sets of single-arm biceps curls and single-leg calf presses were completed to failure with 1-min interset rest periods. Workloads of 30 and 70% one repetition maximum for each exercise were lifted for the LRO and MR trials, respectively. Blood samples were taken preexercise, postexercise, and 15 min postexercise for each experimental condition. Lactate increased significantly in the LRO and MR trials and was not significantly different from each other at any time point. Growth hormone (GH) increased significantly by fourfold from pre- to postexercise in the LRO session but did not change significantly during this time period in the MR and OO trials (8.3 +/- 2.3 vs. 2.1 +/- 1.2 and 2.6 +/- 0.94 microg/l; respectively, P < 0.05). There were no changes in resting total testosterone [T; mean 15.7 +/- 1.6 (SE) nmol/l], free testosterone (FT; 54.1 +/- 4.5 pmol/l), or cortisol (267.6 +/- 22 nmol/l) across all trials and times. In conclusion, with similar lactate responses, light exercise combined with partial vascular occlusion elicits a greater GH response than moderate exercise without occlusion but does not affect T, FT, or cortisol.

Similar hormonal responses to concentric and eccentric muscle actions using relative loading.

Conventional resistance exercise is performed using sequential concentric (CON) and eccentric (ECC) contractions, utilizing the same muscle load. Thus, relative to maximal CON and ECC resistance, the ECC contraction is loaded to a lesser degree. We have recently shown that at the same absolute load, CON contractions are associated with greater growth hormone (GH) but similar total testosterone (TT) and free testosterone (FT) responses compared with ECC contractions and attributed the larger GH response to greater relative CON loading. In the present study, we have examined the same endocrine parameters to six different upper and lower body exercises using relative loading rather than absolute loading, hypothesizing that GH responses would be similar for CON and ECC actions, but TT and FT responses would be greater after ECC contractions. Seven young men with recreational weight training experience completed an ECC and CON muscle contraction trial on two different occasions in a counterbalanced fashion. The exercises consisted of four sets of 10 repetitions of lat pull-down, leg press, bench press, leg extension, military press, and leg curl exercises at 65% of an ECC or CON 1-RM with 90 s between sets and exercises. CON and ECC actions were performed at the same speed. ECC 1-RMs were considered to be 120% of the CON 1-RM for the same exercise. Blood samples were collected before, immediately after, and 15 min after the exercise. GH significantly increased across both trials but was not different between the two trials. Total testosterone was not significantly altered in response to either trial; however, free testosterone concentrations increased in response to both ECC and CON trials. Data suggest that CON and ECC muscle contractions produce similar GH, T, and free testosterone responses with the same relative loading.

Change in sociocultural ideal male physique: An examination of past and present action figures.

The physical dimensions of five contemporary action figures were measured and compared to their original counterparts to determine whether their physiques have become more muscular from their original designs. The circumferences of the neck, chest, arm, forearm, waist, thigh, and calf were measured three separate times using a Scale Master II model 6325. The mean score was then used in subsequent analyses. Except for the waist, it was determined that the body parts of current action figures were significantly larger when compared to those of their original counterparts. The results of this study indicate that action figures have become more muscular and larger over the last 25 years. Furthermore, the increase in action figure dimensions may contribute to the multifactoral development of an idealized body type that focuses on a lean, muscular physique. This occurrence may particularly influence the perceptions of preadolescent males.

Different effects of concentric and eccentric muscle actions on plasma volume.

The effects of concentric (CON) and eccentric (ECC) contractions on Delta plasma volume (PV), heart rate (HR), and lactate in responses to protocols in different body positions were investigated. CON or ECC contractions were performed in either a single-exercise (6 sets of 12 repetitions of leg extensions completed at 80% of 12 repetition maximum [12RM] with 3-minute rest periods) or multiexercise (4 sets of 10 repetitions for both CON and ECC trials of bench press, leg extension, military press, and leg curl at 80% of 10RM with 90-second rest periods) protocols. HR and lactate increased significantly for both protocols from pre- to postexercise for CON but not ECC trials. DeltaPV was greater following both CON single-exercise (-11.48 +/- 1.38%) and multiexercise (-4.64 +/- 0.33%) trials vs. ECC single-exercise (-1.62 +/- 1.69%) and multiexercise (-1.26 +/- 1.20) trials. Data demonstrate ECC exercise in response to single and multiexercise protocols at the same absolute workload as CON exercise produces less cardiovascular stress.

Hormonal responses from concentric and eccentric muscle contractions.

UNLABELLED: Intense resistance exercise can acutely increase testosterone (T), free testosterone (FT), and growth hormone (GH) concentrations, but there are few investigations concerning acute endocrine responses to concentric (CON) and eccentric (ECC) contractile actions. PURPOSE: The purpose of the study was to compare acute anabolic hormonal responses to bouts of dynamic CON and ECC contractions from multiple exercises at the same absolute load. METHODS: Ten young men (age: 24.7 +/- 1.2 yr, weight: 85.45 +/- 24.2 kg, and height: 178 +/- 0.2 cm) completed two trials in counterbalanced fashion consisting of only CON or ECC contractions at the same absolute workload. Subjects performed four sets of 12 repetitions of bench press, leg extension, military press, and leg curl at 80% of a 10-repetition maximum with 90-s rest periods. Blood samples were collected pre-, post-, and 15-min postexercise. RESULTS: There were significant increases in GH, T, and FT and lactate for both trials, but only GH and lactate were greater for the CON trial. CONCLUSION: CON exercise increases GH concentrations to a much greater extent than ECC exercise at the same absolute load, and it is likely that greater GH responses were related to intensity rather than mode of contraction. Also, CON and ECC dynamic contraction trials at the same absolute workload elicited similar small but significant increases in T and FT, indicating that the greater metabolic stress produced by during the CON trial did not affect these hormone responses.

RPE, pain, and physiological adjustment to concentric and eccentric contractions.

PURPOSE: The purpose of the study was to compare perceptual (RPE and pain), cardiac (heart rate), lactate, and endocrine (cortisol) responses with concentric (CON) and eccentric (ECC) resistance exercise protocols using the same absolute workload. METHODS: Eight healthy men with resistance-training experience participated in the study. Subjects completed two experimental trials consisting of either CON contractions or ECC contractions at the same absolute workload for each of four exercises: bench press, leg extension, military press, and leg curl. Subjects performed four sets of 12 repetitions at 80% of 10-RM with 90-s rest periods. Blood samples were taken before, immediately after, and 15-min postexercise. RESULTS: There was a significant trial effect for RPE, with CON exercise eliciting a higher RPE than ECC exercise (6.71 +/- 0.51 and 4.10 +/- 0.27, respectively). A significant trial effect was also demonstrated for pain, with CON exercise producing a higher pain rating than ECC exercise (5.59 +/- 0.41 and 3.23 +/- 0.27, respectively). Significantly higher heart rates and lactates were also demonstrated during the CON trial. For cortisol, a significant interaction was revealed between the pre- and immediate posttrial measures but not an overall trial effect. Correlational analyses revealed a significant relationship between RPE and pain for both trials. CONCLUSIONS: CON exercise elicits greater perceptual (higher RPE and pain rating), cardiac, lactate and cortisol response than ECC exercise at the same absolute workload. Data demonstrate that relative to absolute load, RPE and pain respond to resistance exercise in a similar fashion. Additionally, physiological cues are consistent with these perceptual data.