Ensayo terapéutico con un preparado a base de propoleo propolisina en la giardiasis del humano

Se presentaron los resultados de un ensayo clínico con un preparado a base de propóleo (sustancia elaborada por las abejas) o "Propolisina", con el objeto de demostrar su efectividad como antigiardiásico. Se estudiaron 138 pacientes (48 niños y 90 adultos, en dos grupos) seleccionados aleatoriamente para ser tratados con "Propolisina" o un derivado imidazóilico (tinidazol). El método para el diagnóstico de certeza usado en los niños fue el aspirado duodenal, y en los adultos el frotis de mucosa duodenal, mediante la duodenoscopía. Se utilizaron estudios similares como critério de curación, realizados en un término menor de cinco días después de finalizado el tratamiento. La Propilisina se utilizó con diferentes concentraciones: en los niños -concentración al 10% -los resultados mostraron una curación de un 52%. En 40 adultos, con una concentración del 20%, se obtuvo una eficacia similar a la del Timidazol; al elevar la concentración de la Propolisina al 30% en los restantes 50 pacientes, hubo una mayor efectividad -60% de curación vs. 40% con el tinidazol-. Este trabajo demuestra la utilidad de este producto natural, de fácil obtención en Cuba y sin reacciones secundarias, en el tratamiento de este parasitismo intestinal, lo que resulta de gran trascendencia económica para nuestros pueblos

Ensayo terapéutico con un preparado a base de propoleo propolisina en la giardiasis del humano

Se presentaron los resultados de un ensayo clínico con un preparado a base de propóleo (sustancia elaborada por las abejas) o "Propolisina", con el objeto de demostrar su efectividad como antigiardiásico. Se estudiaron 138 pacientes (48 niños y 90 adultos, en dos grupos) seleccionados aleatoriamente para ser tratados con "Propolisina" o un derivado imidazóilico (tinidazol). El método para el diagnóstico de certeza usado en los niños fue el aspirado duodenal, y en los adultos el frotis de mucosa duodenal, mediante la duodenoscopía. Se utilizaron estudios similares como critério de curación, realizados en un término menor de cinco días después de finalizado el tratamiento. La Propilisina se utilizó con diferentes concentraciones: en los niños -concentración al 10% -los resultados mostraron una curación de un 52%. En 40 adultos, con una concentración del 20%, se obtuvo una eficacia similar a la del Timidazol; al elevar la concentración de la Propolisina al 30% en los restantes 50 pacientes, hubo una mayor efectividad -60% de curación vs. 40% con el tinidazol-. Este trabajo demuestra la utilidad de este producto natural, de fácil obtención en Cuba y sin reacciones secundarias, en el tratamiento de este parasitismo intestinal, lo que resulta de gran trascendencia económica para nuestros pueblos (AU)

[Clinical trial with a preparation based on propolis "propolisina" in human giardiasis]. / Ensayo terapéutico con un preparado a base de propóleo "propolisina" en la giardiasis del humano.

The results of a clinic assay with an extract made out of propolis (bee glue) or "Propolisina" were showed with the aim of showing its effectivity against giardiasis. One hundred and thirty eight patients were studied 48 children and 90 adults, in 2 groups and they selected aleatorily to be treated with "Propolosina" or an imidazole derivate (tinidazole). The method for an exact diagnosis in children was duodenal aspiration and in adults duodenal mucosa frotis by means of duodenoscopy. Similar studies were carried out as a cure criterium in a 5-day term after being through with the treatment. Propolisina was used with different concentrations: in children (concentration at 10%) results showed a 52% cure. In 40 adults (concentration at 20%) it was obtained a similar result to that of tinidazole; and when propolisina concentration was elevated at 30% in the remaining 50 patients there was a higher effectivity (60 of cure Vs 40% with tinidazole). This work shows the success of this natural product, which is very easy to obtain in Cuba and with no side effects in the treatment of this intestinal parasitism, what is of great economical importance for our countries.

Ensayo terapéutico con un preparado a base de propóleo [quot ]propolisina[quot ] en la giardiasis del humano. / [Clinical trial with a preparation based on propolis [quot ]propolisina[quot ] in human giardiasis]

The results of a clinic assay with an extract made out of propolis (bee glue) or [quot ]Propolisina[quot ] were showed with the aim of showing its effectivity against giardiasis. One hundred and thirty eight patients were studied 48 children and 90 adults, in 2 groups and they selected aleatorily to be treated with [quot ]Propolosina[quot ] or an imidazole derivate (tinidazole). The method for an exact diagnosis in children was duodenal aspiration and in adults duodenal mucosa frotis by means of duodenoscopy. Similar studies were carried out as a cure criterium in a 5-day term after being through with the treatment. Propolisina was used with different concentrations: in children (concentration at 10

) results showed a 52

cure. In 40 adults (concentration at 20

) it was obtained a similar result to that of tinidazole; and when propolisina concentration was elevated at 30

in the remaining 50 patients there was a higher effectivity (60 of cure Vs 40

with tinidazole). This work shows the success of this natural product, which is very easy to obtain in Cuba and with no side effects in the treatment of this intestinal parasitism, what is of great economical importance for our countries.

[Identification of substances with biological activity similar to prostaglandins in Cestoda of Moniezia genus]. / Identificación de sustancias con actividad biológica similar a prostaglandinas en cestodos del género Moniezia.

Prostaglandins are biologically active substances which are found in large quantities in the semen of man and sheep, and in lower quantities in the amniotic and menstrual fluids, uterus, lungs, thymus, pancreas, and renal tissue. It is determined that such substances derive from unsaturated fatty acids, and that their main function is the regulation of the cell metabolism. Through the use of thin-plate chromatography as well as through the correspondent pharmacological action of the eluates upon prostaglandin-sensitive isolated organs, the presence of lipidic substances with biological activity similar to that of prostaglandins was determined for the first time ever in extracts of Moniezia cestodes. Such finding is assessed, and the possibility that the diarrhea frequently found in animals infested by such parasites may be caused by the action of their own prostaglandins on the intestinal smooth musculature of the animals, as well as the passibility that the agents inhibitory of the prostaglandin synthesis may be used in the treatment of such parasitosis are expressed.