RESUMO
Biodegradable fixation in craniofacial surgery provides secure fixation while eliminating much of the concern over intracranial migration of metallic plates and screws. One limitation of present biodegradable systems, however, is the need for tapping the drill hole before screw insertion. Herein, a new method of rigid, biodegradable fixation with tacks (Macrapore, Inc., San Diego, CA) is described. The tacks are made of a 70:30 ratio of the L and DL form of polylactic acid (L,DL-PLA). Degradation times range from 18 to 36 months. Newer prototypes are nearly developed for more rapid dissolution times. From April 1999 to February 2000, tack fixation has been applied in 100 patients (51 males, 49 females aged 3 months to 61 years). Indications for operation were craniosynostosis (n = 33); craniofacial trauma or post-traumatic deformities (n = 11); cleft lip and palate (n = 13); craniofacial syndromes (n = 18); other diagnoses (n = 11). Patients underwent fronto-orbital advancement with cranial reshaping; monobloc osteotomy, open reduction-internal fixation of fractures; hypertelorbitism repair; cranioplasty; stabilization of grafts; major cranial reconstruction; zygomatic advancement; alveolar cleft repair; and iliac bone graft donor site protection. Tacks were also used for temporalis muscle and lateral canthal suspension. Follow-up ranged from 16 to 28 months. Complications occurred in 7 patients, 4 of whom had infections and during debridement had biodegradable implants removed. None of the complications appeared to be related to the use of tacks. The tacks are carried in a specially designed holder and may be placed by hand or with the light tap of a mallet on the tack driver. An automatic driver has been developed. Overall, the performance of the tacks has been excellent. They are easily handled by the nursing personnel and rapidly inserted by the surgeon. Stability appears to be excellent. At this time, it is probably preferable to employ tap and screws for orthognathic surgery or other osteotomies with substantial load bearing.
Assuntos
Implantes Absorvíveis , Ossos Faciais/cirurgia , Dispositivos de Fixação Ortopédica , Crânio/cirurgia , Adolescente , Adulto , Materiais Biocompatíveis/química , Transplante Ósseo/instrumentação , Criança , Pré-Escolar , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Craniossinostoses/cirurgia , Craniotomia/instrumentação , Desenho de Equipamento , Ossos Faciais/lesões , Feminino , Seguimentos , Fixação Interna de Fraturas/instrumentação , Osso Frontal/cirurgia , Humanos , Hipertelorismo/cirurgia , Lactente , Ácido Láctico/química , Masculino , Pessoa de Meia-Idade , Órbita/cirurgia , Osteotomia/instrumentação , Poliésteres , Polímeros/química , Crânio/lesões , Músculo Temporal/cirurgia , Zigoma/cirurgiaRESUMO
An increasing number of injectable filler materials for facial wrinkles and folds points to the need for objective measurements of their effectiveness. Patient satisfaction is the goal, but proof of the value of a particular product requires objective measurement. A wrinkle assessment scale was developed as a simple tool for use by plastic surgeons, dermatologists, and aesthetic surgeons who want to assess the changes resulting from injecting filler materials in their patients. By correlating the grade of the wrinkle in the reference photographs with the wrinkle in a patient's face, a classification of 0 to 5 is assigned. Reliability of the scale was assessed by "live" judgment of 76 wrinkles by nine observers. The same rating was given to 92.7 percent of all wrinkles. In a second trial, photographs from 130 wrinkles were presented to eight observers who rated 89.4 percent of all wrinkles equally. A significant correlation of 87 percent was found between subjective ratings and objective wrinkle depth measured by profilometry on 40 silicone impressions. Manufacturers, monitors of clinical trials, health authorities, and most important, patients will benefit from objective data on current and new injectable materials.
Assuntos
Face , Envelhecimento da Pele , Implantes Absorvíveis , Colágeno/administração & dosagem , Técnicas Cosméticas , Humanos , Injeções , FotografaçãoRESUMO
Shortly after the initial application of distraction osteogenesis to the human mandible by McCarthy, distraction osteogenesis was used for gradual lengthening of the midface in children with syndromic craniosynostosis, cleft lip and palate, hemifacial microsomia, and midface hypoplasia from other causes. Both external and internal devices are available for midface distraction. In spite of the many advantages of internal metallic distraction devices, they can be more difficult to remove. By substituting the metallic fixation plates of the Stryker-Leibinger Modular Internal Distraction system, with resorbable MacroPore fixation mesh, only the distractor screw and cable drive need to be removed. Moreover, by using a resorbable stabilizer, the screw and cable components are not needed for the consolidation phase, and can be removed at the completion of active distraction. In this case report of a 4-year-old girl with Crouzon's syndrome, contouring of the resorbable distraction devices was performed using a sterilizable model, 20 mm of distraction was achieved, and 4 days later the distractor screw was replaced with a resorbable stabilizer, resulting in an excellent correction of her midface hypoplasia.
Assuntos
Implantes Absorvíveis , Fixadores Internos , Osteogênese por Distração/instrumentação , Osteotomia de Le Fort/instrumentação , Placas Ósseas , Regeneração Óssea , Parafusos Ósseos , Pré-Escolar , Disostose Craniofacial/cirurgia , Desenho de Equipamento , Feminino , Seguimentos , Humanos , Maxila/cirurgia , Órbita/cirurgia , Osteogênese por Distração/classificação , Osteotomia de Le Fort/classificação , Propriedades de Superfície , Telas CirúrgicasRESUMO
Internal craniofacial distraction has several advantages over distraction with external devices. The scars may be less conspicuous; the devices are buried and therefore easier for patients to tolerate; and the devices are more rigidly secured to bone, preventing uncontrolled rotation of the advancing segments. There are several types of internal devices. The Modular Internal Distraction System developed by one of the authors (S.R.C.) and Stryker-Leibinger, Inc. has had widespread use for midface distraction, but requires a substantial surgical procedure for device removal. This is justified in selected children with syndromic craniosynostosis, who frequently need secondary orbitocranial reconstruction at the conclusion of distraction with any type of device. It would be preferable to develop a device that would retain the positive characteristics of the Modular Internal Distraction system, while allowing easy removability. Moreover, the entire distraction procedure would benefit from a technique that would assist in bone regeneration within the distraction gap. Such a biodegradable, stabilizing device may enable early explanation, accelerating the recovery period, while providing fixation of the distraction gap and protected bone regeneration. Accordingly, we have developed a new, biodegradable distraction device with Macropore, Inc. that may be used with the Modular Internal Distraction system to permit easy removability of the device without the need for a large operation for exposure. Second, we have developed a biodegradable stabilizer that permits earlier removal of the distraction device while providing simultaneous fixation and protected bone regeneration. Last, we have demonstrated the feasibility of midcourse correction of the distraction procedure, should this be necessary for whatever reason.
Assuntos
Implantes Absorvíveis , Regeneração Óssea , Ossos Faciais/cirurgia , Fixadores Internos , Osteogênese por Distração/instrumentação , Adolescente , Regeneração Óssea/fisiologia , Parafusos Ósseos , Craniossinostoses/cirurgia , Remoção de Dispositivo , Desenho de Equipamento , Assimetria Facial/cirurgia , Ossos Faciais/fisiopatologia , Estudos de Viabilidade , Humanos , Masculino , Mandíbula/anormalidades , Mandíbula/cirurgia , Côndilo Mandibular/anormalidades , Côndilo Mandibular/cirurgia , Telas Cirúrgicas , Síndrome , Zigoma/anormalidades , Zigoma/cirurgiaRESUMO
Management of traumatic auricular injuries in children does not differ qualitatively from that in adults. The more common, simple injuries in children can be as readily treated by their pediatricians as those in adults are by their primary care physicians. However, children are more likely to need general anesthesia for significant repairs. A comprehensive initial assessment of the injury site remains the foundation for treatment planning. An appreciation for the variety of treatment options available for the injured ear should facilitate an interaction between the pediatrician and the surgeon when injury is complex and should lead to the best outcome for each child.
Assuntos
Orelha Externa/lesões , Queimaduras/diagnóstico , Queimaduras/terapia , Criança , Contusões/diagnóstico , Contusões/terapia , Deformidades Adquiridas da Orelha/diagnóstico , Deformidades Adquiridas da Orelha/cirurgia , Humanos , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/terapia , Ferimentos Penetrantes/diagnóstico , Ferimentos Penetrantes/terapiaRESUMO
The aim of this prospective study was to histomorphometrically evaluate at various time intervals the mineralization stage and process of an allogeneic-xenogeneic bone graft used in sinus augmentation procedures. One biopsy was taken from 20 patients at either 6, 8, 10, or 12 months after sinus augmentation. Immediately following the biopsy, an endosseous implant was placed into the biopsy site. This protocol provided 4 groups of 5 patients each, based on healing time following sinus augmentation. Using backscattered electron image analysis, the specimens were histomorphometrically analyzed to determine the volume fractions of residual cancellous bone, newly formed bone, soft tissue, bovine hydroxyapatite, and "remineralized" freeze-dried demineralized bone allograft (rDFDBA). "Remineralization" of DFDBA particles was observed in a few areas in all specimens. Polarized light microscopy showed that only the 12-month biopsies had a predominance of lamellar bone formation. The area within the biopsies that represented the residual alveolar ridge consisted of 32.6% +/- 8.6% (mean +/- SD) of bone. In the grafted area of the biopsies the volume fraction of newly formed bone at 12 months (20.7% +/- 8.3%) was significantly higher (P < .05, analysis of variance) than at 6 months (8.1% +/- 3.0%). There was no statistically significant difference between newly formed bone in the inferior, central, and superior grafted areas in all 4 time intervals. This prospective study indicates that the mineralization process of an allogeneic-xenogeneic sinus graft is incomplete 6 months after the sinus augmentation procedure. New bone formation increased up to 12 months postaugmentation; however, it remained lower than the volume of residual bone.
Assuntos
Transplante Ósseo/métodos , Implantação Dentária Endóssea/métodos , Seio Maxilar/cirurgia , Procedimentos Cirúrgicos Pré-Protéticos Bucais , Análise de Variância , Animais , Regeneração Óssea/fisiologia , Bovinos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estatísticas não Paramétricas , Resultado do TratamentoRESUMO
BACKGROUND: With the increased use of fusion cages to achieve lumbar intervertebral fusion, the question arises as to the potential for bone ingrowth from the host bone through the entire cage. Is it even necessary to have an autogenous graft to achieve total bone incorporation? METHODS: Nine adult male goats had fusion cages implanted into three vertebral bodies. The design was Surgical Dynamics/Ray Fusion Cage, measuring 21 mm x 14 mm. In each animal, one fusion cage was filled with autogenous graft, one with hydroxyapatite, porous granules, and the other with nonporous granules. Amount of new bone formation was determined by backscatter electron microscopy at 3 months post implantation in all animals. RESULTS: The histologic section shows that there was total incorporation in all specimens at 3 months. There was slightly more new bone (43%) with the nonporous granules compared with the porous granules (35%). The amount of residual void space was about the same in all specimens, indicating that the amount of new bone formation was similar and not statistically different in cages filled with hydroxyapatite granules versus granules of autogenous bone. CONCLUSION: This study confirms that total incorporation by ingrowth of new bone can be expected in fusion cages. The amount of ingrowth is about the same for autogenous graft versus hydroxyapatite granules. Apparently, it is not necessary to use bone graft to achieve successful bone incorporation if an acceptable biocompatable lattice, such as hydroxyapatite granules, is used.
Assuntos
Transplante Ósseo/métodos , Durapatita , Vértebras Lombares/cirurgia , Fusão Vertebral/métodos , Animais , Modelos Animais de Doenças , Cabras , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/patologia , Masculino , Microscopia Eletrônica , Radiografia , Fusão Vertebral/instrumentação , Transplante AutólogoRESUMO
The purpose of this study was to compare spontaneous bone regeneration, osteoconduction, and bone autografting in critical size calvarial and mandibular defects (defects which do not heal spontaneously during the lifetime of the animal) that were protected from soft-tissue interposition. Eighteen adult mongrel dogs underwent osteotomies to create a unilateral 30-mm segmental defect in the midbody of the edentulated right mandible and bilateral 15-mm x 20-mm full-thickness window defects in the parietal bones. The defects were either left empty, implanted with coralline hydroxyapatite (HA) blocks, or autografted with iliac cancellous bone. All defects were protected with a macroporous titanium mesh and the segmental mandibular defects were additionally stabilized by internal plate fixation. Specimens were retrieved after 2 and 4 months and three undecalcified longitudinal central sections including the osteotomy interfaces were prepared from each specimen for histometry and histology. Sections were analyzed for volume fractions of bone, soft tissue, and implant using scanning electron microscopy, backscatter electron imaging and histometric computer software. In the mandibular model, the empty defects exhibited the greatest amount of bone formation after 4 months (47.3 percent), which was greater than the amount of bone in the autografted group (34.8 percent) and significantly greater than the amount of bone within the hydroxyapatite implants (19.0 percent, p < 0.05). In the cranial defects, the autografted specimens demonstrated the greatest volume fraction of bone after 4 months (27.3 percent), which was significantly greater than within both the empty defects (18.2 percent, p < 0.05) and the hydroxyapatite implants (18.2 percent, p < 0.05). New bone formation in the mandibular defects united the cut ends at 4 months regardless of treatment and originated predominantly from the periosteum which remained present only along the alveolar border after surgical closure. In the calvarial defects, periosteum was not preserved and bone regenerated centripetally, originating from the diploë without any evidence of dural osteogenesis. Bone bridging was incomplete in the empty cranial defects at 4 months. In both the mandibular and cranial specimens, new bone at 2 months was a mixture of woven and parallel fibered bone. At 4 months, the new bone had remodeled almost entirely into mature Haversian bone. This study demonstrated a remarkable ability of defect protection with a macroporous protective sheet to facilitate bone regeneration in critical size mandibular and cranial bone defects. When active osteogenic periosteum was present, as in our mandibular model, we concluded that defect protection alone was sufficient to allow for healing even of critical size defects. When periosteum was absent as in our cranial defects, the limited spontaneous bone formation benefited from the added contributions of cancellous grafting and osteoconductive implants, both of which promoted bone bridging across the defects. We suggest that in the future a resorbable macroporous protective sheet would be advantageous in comparison to a titanium mesh to facilitate bone regeneration by preventing soft-tissue prolapse and allowing the migration of mesenchymal cells and the proliferation of blood vessels from the adjacent soft tissues into the bone defect. Finally, this study identified the need to differentiate critical size defects into those with and without defect protection and periosteum.
Assuntos
Regeneração Óssea , Transplante Ósseo/métodos , Doenças Mandibulares/cirurgia , Osteogênese , Osso Parietal/cirurgia , Animais , Materiais Biocompatíveis , Doenças Ósseas/patologia , Doenças Ósseas/cirurgia , Placas Ósseas , Remodelação Óssea/fisiologia , Transplante Ósseo/patologia , Tecido Conjuntivo/patologia , Cães , Durapatita , Microanálise por Sonda Eletrônica , Seguimentos , Ósteon/patologia , Processamento de Imagem Assistida por Computador , Doenças Mandibulares/patologia , Mesoderma/patologia , Mesoderma/fisiologia , Microscopia Eletrônica de Varredura , Osteotomia , Osso Parietal/patologia , Periósteo/patologia , Periósteo/fisiologia , Porosidade , Próteses e Implantes , Software , Telas Cirúrgicas , Titânio , Transplante Autólogo , CicatrizaçãoRESUMO
This study was designed to measure implant osseointegration using different surface treatments. Bilateral distal intramedullary implantation of titanium cylinders 25 mm x 5 mm was performed in 60 rabbits. The 3 surfaces tested were fiber mesh, mean pore size 400 microns; grit-blasted, mean surface roughness 6 microns; and acid-etched, mean surface roughness 18 microns. Scanning electron microscopy was used to measure the percentage of the surface of each implant in contact with bone at 2, 6, and 12 weeks postimplantation. Mechanical pull-out testing of the bone-implant interface was performed at 12 weeks. Overall, acid-etched surfaces demonstrated greater mean osseointegration than fiber mesh surfaces. All 3 surfaces demonstrated similar interface strengths. Acid etching has potential as a means of enhancing bony apposition in cementless fixation.
Assuntos
Implantes Experimentais , Osseointegração/fisiologia , Titânio , Animais , Fêmur/fisiologia , Fêmur/cirurgia , Masculino , Porosidade , Coelhos , Propriedades de Superfície , Fatores de TempoRESUMO
RATIONALE AND OBJECTIVES: The authors evaluate whether dual-energy x-ray absorptiometry (DXA) is a reliable method to determine the density of natural coralline hydroxyapatite (HA) blocks used as bone graft substitutes. METHODS: To evaluate the basic density of HA blocks from the same coral heads with and without titanium meshes, densitometry of 12 HA-500 blocks (genus Goniopora) and 12 HA-200 blocks (genus Porites) was performed. In addition, density measurements of 30 HA blocks (HA-500, n = 15; HA-200, n = 15) from different coral heads were obtained to assess if the originating coral head influences the basic density of blocks within one coral genera. To assess standard deviation serial measurements on eight coralline HA blocks, four with titanium meshes and four without were performed. In the ex vivo study, densitometry of 12 HA blocks (HA-500, n = 4; HA-200, n = 8) used as bone graft substitutes in the mandibles and craniums of adult mongrel dogs was performed. Densities were measured after bone ingrowth for 2 and 4 months, respectively. All measurements were obtained with a Lunar DPX with scan mode "slow 750" in the spine program with the regions-of-interests selected manually. Bone ingrowth was assessed by computer-assisted histomorphometry, which was considered the gold standard. Statistical analysis was performed to correlate the densities of plain HA blocks with and without meshes to the specific weights of the blocks. RESULTS: Significant positive correlation was found between the density of each HA block (both coral species) with and without meshes and the calculated specific weights. Densitometry values showed no significant differences depending on the originating coral heads. Standard deviation ranged between +/- 3.8% and +/- 4.1% (HA-500) and between +/- 3.0% and +/- 3.8% (HA-200). Hydroxyapatite-500 blocks showed marked increased densities between 15% and 34% after 4 months in three specimens in which bone ingrowth between 16.9% and 21.1% was revealed by histomorphometry; no increase of density was observed in one specimen, which presented only minimal bone ingrowth and signs of infection. Despite bone invasion between 12% and 25.8%, no increased densities were observed for HA-200 implants. CONCLUSIONS: Dual-energy x-ray absorptiometry is an accurate and reproducible modality to assess the densities of plain coralline HA blocks and to monitor bone ingrowth into coralline HA-500 but not into HA-200 block implants.
Assuntos
Absorciometria de Fóton , Densidade Óssea , Durapatita , Próteses e Implantes , Animais , Cães , TitânioRESUMO
This study retrospectively evaluated the results of 36 sinus-lift graft augmentations performed to place 66 implant cylinders in the posterior maxilla where vertical bone height was less than ideal. Grafts were accomplished with porous hydroxyapatite (HA) alone, porous HA mixed with autogenous bone removed from the iliac crest, and HA combined with autogenous bone removed from within the mouth. Nineteen core biopsy specimens were taken from different grafts at time intervals ranging from 4 to 36 months from the time of grafting. These cores were evaluated using histomorphometric analysis to yield data comparing volume fractions of bone formation, allowing comparison of different graft materials and healing times. Grafts using porous HA alone on mean produced 16.38% bone by volume after 6 months. After the same healing time, grafts using HA and hip bone on mean produced 19.30% bone by volume compared with an 11.30% bone volume when using HA and bone harvested intraorally. Evaluation of cores taken at 19 and 36 months revealed greater volumes of bone formation. Recommendations based on clinical and histologic results are discussed in detail.
Assuntos
Aumento do Rebordo Alveolar/métodos , Implantação Dentária Endóssea , Implantes Dentários , Maxila/cirurgia , Seio Maxilar/cirurgia , Adolescente , Adulto , Idoso , Biópsia , Transplante Ósseo/métodos , Transplante Ósseo/patologia , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Durapatita , Feminino , Seguimentos , Humanos , Ílio , Arcada Osseodentária , Masculino , Maxila/patologia , Seio Maxilar/patologia , Pessoa de Meia-Idade , Osteogênese , Próteses e Implantes , Falha de Prótese , Estudos Retrospectivos , Titânio , Resultado do Tratamento , CicatrizaçãoRESUMO
PURPOSE: This study was undertaken to determine the resorption rate of porous ceramic implants. The hypothesis was that implants placed in soft tissues would degrade more rapidly than implants placed in bone. MATERIALS AND METHODS: To test this hypothesis, implants were manufactured by applying a thin coating of hydroxylapatite onto an interconnected, porous calcium carbonate substrate. Control implants were made entirely of hydroxylapatite with identical microstructure. Two adult dogs received a total of 56 implants placed in the femur, skeletal muscle, and subcutaneous tissues. After killing the animals at 4 months, the specimens were removed, embedded in plastic, sectioned, and either stained for light microscopic examination or subjected to quantitative image analysis using a scanning electron microscope. RESULTS: Contrary to the hypothesis, the rate of degradation was faster for implants placed in bone than in soft tissue. Within the 4 months, degradation was 24% to 63% in bone, depending on the composition. However, it was not statistically significant in either intramuscular or subcutaneous tissue. A surprising observation was that bone ingrowth occurred in 67% of the implants placed in soft tissues. On average, it was 4.3% in intramuscular sites and 6.6% in subcutaneous sites. This bone was histologically normal in 71% of the implants containing bone. CONCLUSION: This study demonstrates that porous ceramic implants composed of hydroxylapatite on calcium carbonate will degrade more rapidly in bone defects than in soft tissue sites. In addition, implants with interconnected porosity and surfaces of hydroxylapatite will become ingrown with bone even after placement in soft tissues. The exact mechanisms for both of these phenomena are not understood.
Assuntos
Regeneração Óssea , Carbonato de Cálcio/farmacocinética , Cerâmica/farmacocinética , Durapatita/farmacocinética , Próteses e Implantes , Análise de Variância , Animais , Biodegradação Ambiental , Osso e Ossos/metabolismo , Cnidários , Tecido Conjuntivo/metabolismo , Cães , Músculo Esquelético/metabolismo , PorosidadeRESUMO
Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineralized bone matrix (DBM) would conceivably create a composite with both osteoconductive and osteoinductive properties. This pilot study evaluated the healing of rabbit cranial defects that had been filled with cHA or cHA augmented with a DBM gel formed by adding glycerol to the DBM particulate. Data from these were then compared to unfilled defects from a previous study. Results indicated enhancement of new bone formation and an increase in the rate of healing in the defects filled with the cHA-DBM gel composite. Further studies are warranted.
Assuntos
Técnica de Desmineralização Óssea , Matriz Óssea/ultraestrutura , Substitutos Ósseos , Cerâmica , Durapatita , Teste de Materiais , Osseointegração , Próteses e Implantes , Animais , Microscopia Eletrônica , Coelhos , Distribuição Aleatória , Crânio/cirurgia , Propriedades de SuperfícieRESUMO
This study used histomorphometric analysis to quantitate the bone composition of four different sinus grafting materials biopsied at the time of implant installation. The study consisted of five patients in whom eight bone biopsies were obtained from seven grafted sites. The grafting materials consisted of hydroxylapatite (HA) granules mixed with cortical chin bone, HA mixed with demineralized bone powder, HA alone, and cortical chin bone alone. Histomorphometry was performed using backscattered scanning electron microscopy images and a computerized image analysis system. The biopsy cores yielded 46 sections from which a total of 255 fields, measuring 2.0 mm x 2.0 mm each, were imaged and analyzed. The biopsy cores contained 44.4% bone after grafting with HA granules and chin bone, 59.4% bone after grafting with chin bone alone, 20.3% bone after grafting with HA granules alone, and 4.6% bone after grafting with HA granules and demineralized bone powder. The small number of biopsies did not permit analysis of statistical significance. However, this study demonstrated the feasibility of correlating mineralized tissue composition of different sinus grafting materials with clinical outcome after dental implant installation.
Assuntos
Materiais Biocompatíveis , Transplante Ósseo/métodos , Seio Maxilar/cirurgia , Procedimentos Cirúrgicos Pré-Protéticos Bucais/métodos , Próteses e Implantes , Idoso , Perda do Osso Alveolar/cirurgia , Matriz Óssea/transplante , Queixo/cirurgia , Implantes Dentários , Durapatita , Feminino , Humanos , Hidroxiapatitas , Masculino , Doenças Maxilares/cirurgia , Pessoa de Meia-IdadeRESUMO
Bone-graft reconstruction of large orbital defects has been difficult because of a lack of marginal support of the grafts and unpredictable resorption. A titanium mesh orbital plate has been developed to provide this marginal support for bone grafts. However, the problem of unpredictable bone-graft resorption remains. To determine if this plate has any effect on graft resorption, this study was designed to quantitate the dimensions and composition of bone autografts (1) with and without titanium plate support and (2) in the anterior and posterior orbit. Bilateral full-thickness large orbital floor defects were surgically created in five monkeys, and a titanium orbital floor plate was fixed with screws into the right orbit. Two iliac crest grafts were measured and placed transversely and without fixation in each orbit, one anterior and the other posterior to the axis of the globe. The orbits were retrieved 28 weeks after surgery and were analyzed histologically and histometrically. Comparison of the supported and nonsupported grafts revealed no differences in their histologic appearance. There were three significant histometric findings: (1) resorption of bone was similar for those grafts which spanned an orbital floor defect and those which were supported by a titanium plate; (2) resorption of grafts in the posterior orbit did not differ from that of grafts in the anterior orbit; and (3) resorption of approximately one-third of bone-graft thickness and width had taken place during the 28-week study interval. We conclude that the benefits of bone-graft support by a titanium mesh orbital floor plate are not offset by any alteration in bone-graft resorption.
Assuntos
Placas Ósseas , Ílio/transplante , Órbita/cirurgia , Titânio , Animais , Reabsorção Óssea , Ílio/anatomia & histologia , Ílio/fisiologia , Macaca fascicularis , Órbita/anatomia & histologia , Órbita/fisiologiaRESUMO
The authors discuss a recently described bone graft material substitute derived from sea corals. They briefly review its background leading to the potential for clinical use. Radiologic evaluation is provided, with attention directed to its characteristics, compared with other bone grafts.
Assuntos
Materiais Biocompatíveis , Transplante Ósseo/diagnóstico por imagem , Osso e Ossos/diagnóstico por imagem , Hidroxiapatitas , Humanos , Imageamento por Ressonância Magnética , RadiografiaRESUMO
The influence of the addition of an osteoinductive protein, capable of inducing extraskeletal ossification, on bone ingrowth into coralline porous hydroxyapatite was evaluated in the rabbit using a calvarium onlay model. Twenty-three rabbits received hydroxyapatite implants (10 x 10 x 2 mm) prepared with and without osteoinductive protein. These were implanted on the frontal bone and secured by wire fixation after 0.25 mm of the cortical surface was abraded. The implants were harvested at 3 and 4 months and analyzed for percentage of bone ingrowth by histologic examination of decalcified H&E sections and by scanning electron microscope backscatter image analysis. The osteoinductive protein-treated implants demonstrated significantly greater amounts of bone ingrowth at both 3 (52.0 versus 10.3 percent; p less than 0.001) and 4 months (66.1 versus 39.2 percent; p less than 0.005) than the untreated implants. The type of bone found in all osteoinductive protein-treated implants was predominantly lamellar. Untreated implants contained mostly woven bone at 3 months, with increasing amounts of lamellar bone appearing at 4 months. These results suggest that the combination of a bone-inducing protein and a suitable osteoconductive matrix may provide an alternative to bone grafting.
Assuntos
Osso e Ossos/fisiologia , Hidroxiapatitas , Próteses e Implantes , Animais , Osso e Ossos/anatomia & histologia , Durapatita , Porosidade , Coelhos , Distribuição AleatóriaRESUMO
Using an extra-oral approach, subperiosteal pockets were created bilaterally over zygomatic and mandibular areas in six Rhesus monkeys. One side of each anatomic site received a Proplast I implant and the contralateral a nonporous hydroxylapatite (NPHA) block. Two animals were killed postoperatively at 3, 6, and 12 months, and the implants retrieved en bloc for histologic evaluation. Clinical evaluation showed the Proplast implants more stable than NPHA implants. Histologic evaluation for Proplast implants demonstrated complete encapsulation, fibrous tissue infiltration, fragmentation of implants, and some giant cell reaction. The NPHA implants were completely encapsulated with fibrous tissues, and no giant cell response, fragmentation, biodegradation, or bone formation was observed. We concluded that the Proplast was more stable than NPHA implants, but the NPHA produced less inflammatory cell and giant cell reaction.
Assuntos
Hidroxiapatitas , Mandíbula/cirurgia , Politetrafluoretileno , Proplast , Próteses e Implantes , Zigoma/cirurgia , Animais , Materiais Biocompatíveis , Tecido Conjuntivo/patologia , Durapatita , Feminino , Células Gigantes de Corpo Estranho/patologia , Macaca mulatta , Mandíbula/patologia , Propriedades de Superfície , Fatores de Tempo , Zigoma/patologiaRESUMO
Using extraoral incisions, subperiosteal pockets were created bilaterally over the zygomatic and mandibular areas in six rhesus monkeys. One side of each anatomic site received a dense block of hydroxylapatite (HA) implant, and the contralateral side received an equivalent-sized block of porous HA implant. Monkeys were killed at 3, 6, and 12 months, and the implants were manually tested for mobility. The implants were then retrieved in block specimens. Half of each specimen was decalcified, embedded in paraffin, and stained. The other half was embedded in plastic, and sections were stained or carbon coated for scanning electron microscope histometry. The dense HA implants showed complete fibrous encapsulation and they popped out when cut in half. The porous HA implants were attached to the underlying cortex by bone ingrowth. The porous implant volume sampled within 2.5 mm of underlying cortex contained 33.0% HA matrix and 35.7% bone. The surface area of the porous HA matrix (4.8 mm2/mm3) was 54.3% covered by bone ingrowth. It is hypothesized that micromotion may have accounted for the lack of osseointegration of the dense HA specimens. In contrast, the early ingrowth of fibrous tissue into the porous HA block might be responsible for reducing micromotion to levels acceptable for ingrowth of bone. The contrasting biologic response of implant sites to two variants of the same implant material supports the value of comparative studies to permit informed surgical selection decisions.
Assuntos
Hidroxiapatitas , Mandíbula/cirurgia , Próteses e Implantes , Zigoma/cirurgia , Animais , Tecido Conjuntivo/anatomia & histologia , Durapatita , Desenho de Equipamento , Feminino , Processamento de Imagem Assistida por Computador , Macaca mulatta , Mandíbula/anatomia & histologia , Osteogênese , Propriedades de Superfície , Fatores de Tempo , Cicatrização , Zigoma/anatomia & histologiaRESUMO
The dependence of strength on the amount of bone growth into a hydroxyapatite material made from coral was investigated. Block and granular forms of the material were implanted into cortical and trabecular regions of the skeletons of 16 dogs. The results were examined after 4, 8, 12 and 16 wk, with four dogs in each experimental group. When implanted into cortical bone, the bending strength of the implant material was found to be highly correlated with the amount of pore space which had become occupied by bone (r = 0.92, P less than 0.005 for the block form; r = 0.84, P less than 0.005 for the granular form). Multiple regression analysis showed that six histomorphometric measures of ingrowth accounted for 96% of the variability in bending strength of the block material, and there were no significant differences between block and granular forms of the material. On the other hand, when implanted into trabecular bone, the block form of the material achieved greater compressive strength than the granular form. While both strength and ingrowth increased with time, there were poor correlations between these two variables. Finally, when the material is implanted into trabecular bone, it becomes stronger in compression than the surrounding bone; when implanted in cortical bone, linear modelling suggests that resorption and replacement of the implant would be required to approximate the bending strength of the surrounding bone.