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1.
Ann Otol Rhinol Laryngol ; 132(7): 731-737, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35899590

RESUMO

OBJECTIVES: This study assesses the impact of adverse histologic risk factors including worst pattern of invasion (WPOI), predominant pattern of invasion (PPOI), tumor budding, and tumor infiltrating lymphocytes (TILS), on risk of recurrence in patients with early-stage Oral Cavity Squamous Cell Carcinoma (OCSCC). METHODS: Retrospective chart review was performed at a single institution to identify patients with OCSCC who underwent surgical excision. Inclusion criteria included T1-T2 stage disease based on AJCC seventh edition guidelines, no cervical lymph node involvement, no perineural invasion (PNI), no lymphovascular invasion (LVI), no post-operative adjuvant radiation therapy, and cancer involving only the oral tongue or floor of mouth. Patients were excluded if they had positive final margins. A subset of 35 patients were selected for additional histologic review to determine WPOI, PPOI, TB, and TILS. Bivariable and multivariable cox analysis were performed to determine variables associated with recurrence. RESULTS: One hundred and sixty-one patients met criteria and were included in the analysis. Variables that were significantly associated with recurrence on bivariable analysis included tumors with high risk PPOI (groups 4 and 5; P = .021), TB with 10 or more buds (P = .021), T-stage (P = .001), neck dissection (P = .03), and depth of invasion (DOI) >4 mm (P = .044). Multivariable cox proportional hazards found T-stage (HR: 6.40; 95% CI 1.67, 24.50; P = .007), neck dissection (HR: 0.23; 95% CI 0.07, 0.82; P = .023), and TBs (HR: 1.17; 95% CI 1.05, 1.30; P = .006) to be most predictive of recurrence. CONCLUSIONS: TB is a strong predictor of recurrence. WPOI, PPOI, and TILS were not statistically significant risk factors for recurrence.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Bucais , Humanos , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Estudos Retrospectivos , Estadiamento de Neoplasias , Invasividade Neoplásica , Neoplasias Bucais/cirurgia , Neoplasias Bucais/patologia , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/patologia , Fatores de Risco , Recidiva Local de Neoplasia/epidemiologia , Recidiva Local de Neoplasia/patologia , Neoplasias de Cabeça e Pescoço/patologia , Prognóstico
2.
Eur Arch Otorhinolaryngol ; 273(7): 1649-61, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25926124

RESUMO

Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.


Assuntos
Ameloblastoma , Neoplasias Maxilomandibulares , Procedimentos Cirúrgicos Bucais/métodos , Procedimentos de Cirurgia Plástica/métodos , Ameloblastoma/patologia , Ameloblastoma/fisiopatologia , Ameloblastoma/cirurgia , Gerenciamento Clínico , Humanos , Neoplasias Maxilomandibulares/patologia , Neoplasias Maxilomandibulares/fisiopatologia , Neoplasias Maxilomandibulares/cirurgia , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Neoplasias Mandibulares/patologia , Maxila/diagnóstico por imagem , Maxila/patologia , Prognóstico
3.
J Robot Surg ; 9(4): 311-4, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26530843

RESUMO

Inability to integrate surgical navigation systems into current surgical robot is one of the reasons for the lack of development of robotic endoscopic skull base surgery. We describe an experiment to adapt current technologies for real-time navigation during transoral robotic nasopharyngectomy. A cone-beam CT was performed with a robotic C-arm after the injecting contrast into common carotid artery. 3D reconstruction of the skull images with the internal carotid artery (ICA) highlighted red was projected on the console. Robotic nasopharyngectomy was then performed. Fluoroscopy was performed with the C-arm. Fluoroscopic image was then overlaid on the reconstructed skull image. The relationship of the robotic instruments with the bony landmarks and ICA could then been viewed in real-time, acting as a surgical navigation system. Navigation during robotic skull base surgery is feasible with available technologies and can increase the safety of robotic skull base surgery.


Assuntos
Artéria Carótida Primitiva/anatomia & histologia , Tomografia Computadorizada de Feixe Cônico/métodos , Fluoroscopia/métodos , Nasofaringe/cirurgia , Procedimentos Cirúrgicos Robóticos/métodos , Software , Meios de Contraste , Estudos de Viabilidade , Humanos
4.
J Reconstr Microsurg ; 28(7): 457-64, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22744894

RESUMO

Minimally invasive harvest of the latissimus dorsi (LD) muscle is a desirable goal because of both the wide utility of this muscle and the length of incision required to harvest it. In this study, robotic harvest of the LD muscle was evaluated in a cadaver model and clinical series. Ten LD flaps were robotically harvested in eight cadavers. Positioning, port placement, procedural steps, instrumentation, and technical obstacles were all critically analyzed and reported. After modifying the technique based on experience gained in the cadaver study, eight LD muscles were robotically harvested and transferred in eight patients. Access included a short axillary incision and two additional port sites along the anterior border of the muscle. Insufflation was used to maintain the optical cavity. Indications included pedicled flaps for implant-based breast reconstruction and free flaps for scalp reconstruction. All flaps were successfully transferred without converting to open technique. In the clinical series, average time for setup and port placement was 23 minutes, and average robotic time was 1 hour and 51 minutes. There were no major complications. Robotic harvest of the LD is feasible and effective and permits full muscle harvest without a visible incision.


Assuntos
Músculo Esquelético/cirurgia , Robótica , Coleta de Tecidos e Órgãos/métodos , Idoso , Cadáver , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Retalhos Cirúrgicos
5.
Ann Diagn Pathol ; 14(6): 396-401, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21074686

RESUMO

Intraosseous salivary gland carcinomas are extremely rare, comprising only 2% to 3% of all mucoepidermoid carcinomas (MECs) reported. The t(11;19) translocation and its CRTC1/MAML1 fusion transcript have been identified in MEC at different sites and are believed to be associated with the development of a subset of these tumors. However, the status of the fusion transcript has not been reported in intraosseous MEC. Here, we report 3 examples of central MEC of the mandible, including a case with a history of primary retromolar MEC. Reverse transcriptase-polymerase chain reaction and DNA sequencing analyses of the microdissected components of these tumors were used for the detection and verification of the fusion transcript. We identified, for the first time, the t(11;19) fusion gene transcript in central MEC, including in the previous primary retromolar MEC. No fusion transcript was detected in the second primary noncentral MEC or in another central MEC. The results indicate that central MEC can manifest the fusion transcript. This finding may have diagnostic and histogenetic roles in the future analysis of this entity.


Assuntos
Carcinoma Mucoepidermoide/genética , Proteínas de Ligação a DNA/genética , Fusão Gênica/genética , Neoplasias Mandibulares/genética , Proteínas Nucleares/genética , Fatores de Transcrição/genética , Adolescente , Adulto , Carcinoma Mucoepidermoide/diagnóstico , Carcinoma Mucoepidermoide/patologia , DNA de Neoplasias/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico , Neoplasias Mandibulares/patologia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Transativadores , Adulto Jovem
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