1.
Bioorg Med Chem Lett
; 13(1): 119-23, 2003 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12467630
RESUMO
The 4-(3-phenylprop-1-yl)piperidine moiety of the 1,3,4-trisubstituted pyrrolidine CCR5 antagonist 1 was modified with electron deficient aromatics as well as replacement of the benzylic methylene with sulfones, gem-difluoromethylenes and alcohols in an effort to balance the antiviral potency with reasonable pharmacokinetics.