RESUMO
The authors describe an experimental study on rabbits whereby the development of sarcomas was induced following injection into the knee joint with 9-10-dimethyl-1-2-benzanthracene. The results of the experiment are in contrast to those of other authors as no "synovialoma" or synovial sarcoma developed but only morphological patterns which might belong to malignant fibrous histiocytoma and occasionally fibrosarcoma. In accord with our results the hypothesis is discussed that all malignant mesenchymal neoplasias result from a not clearly identifiable pluripotent mesenchymal stem cell.
Assuntos
9,10-Dimetil-1,2-benzantraceno/efeitos adversos , Benzo(a)Antracenos/efeitos adversos , Neoplasias Ósseas/induzido quimicamente , Fibrossarcoma/induzido quimicamente , Histiocitoma Fibroso Benigno/induzido quimicamente , Articulação do Joelho , Animais , Neoplasias Ósseas/patologia , Modelos Animais de Doenças , Fibrossarcoma/patologia , Histiocitoma Fibroso Benigno/patologia , Injeções Intra-Articulares , CoelhosRESUMO
We report on observations in the progress of Calcinosis Interstitialis Universalis in three generations of one family. Some members could be followed for more than 20 years. Each member of the family was examined and the course of the disease described. Part of the family underwent functional analysis by a specialist in internal medicine. Our conclusion is, that, at least, in this family, the disease is in all probability, a genetically fixed, dominant hereditary disease.
