Speech compensation for time-scale-modified auditory feedback.

PURPOSE The purpose of this study was to examine speech compensation in response to time-scale-modified auditory feedback during the transition of the semivowel for a target utterance of /ija/. METHOD Each utterance session consisted of 10 control trials in the normal feedback condition followed by 20 perturbed trials in the modified auditory feedback condition and 10 return trials in the normal feedback condition. The authors examined speech compensation and the aftereffect in terms of 3 acoustic features: the maximum velocities on the (a) F1 and (b) F2 trajectories (VF1 and VF2) and (c) the F1-F2 onset time difference (TD) during the transition. They also conducted a syllable perception test on the feedback speech. RESULTS Speech compensation was observed in VF1, VF2, and TD. The magnitudes of speech compensation in VF1 and TD monotonically increased as the amount of the time-scale perturbation increased. The amount of speech compensation increased as the phonemic perception change increased. CONCLUSIONS Speech compensation for time-scale-modified auditory feedback is carried out primarily by changing VF1 and secondarily by adjusting VF2 and TD. Furthermore, it is activated primarily by detecting the speed change in altered feedback speech and secondarily by detecting the phonemic categorical change.

Prediction of shot success for basketball free throws: visual search strategy.

In ball games, players have to pay close attention to visual information in order to predict the movements of both the opponents and the ball. Previous studies have indicated that players primarily utilise cues concerning the ball and opponents' body motion. The information acquired must be effective for observing players to select the subsequent action. The present study evaluated the effects of changes in the video replay speed on the spatial visual search strategy and ability to predict free throw success. We compared eye movements made while observing a basketball free throw by novices and experienced basketball players. Correct response rates were close to chance (50%) at all video speeds for the novices. The correct response rate of experienced players was significantly above chance (and significantly above that of the novices) at the normal speed, but was not different from chance at both slow and fast speeds. Experienced players gazed more on the lower part of the player's body when viewing a normal speed video than the novices. The players likely detected critical visual information to predict shot success by properly moving their gaze according to the shooter's movements. This pattern did not change when the video speed was decreased, but changed when it was increased. These findings suggest that temporal information is important for predicting action outcomes and that such outcomes are sensitive to video speed.

Dynamic visual acuity in baseball players is due to superior tracking abilities.

PURPOSE: Dynamic visual acuity (DVA) is defined as the ability to discriminate the fine parts of a moving object. DVA is generally better in baseball players than that in nonplayers. Although the better DVA of baseball players has been attributed to a better ability to track moving objects, it might be derived from the ability to perceive an object even in the presence of a great distance between the image on the retina and the fovea (retinal error). However, the ability to perceive moving visual stimuli has not been compared between baseball players and nonplayers. METHODS: To clarify this, we quantitatively measured abilities of eye movement and visual perception using moving Landolt C rings in baseball players and nonplayers. RESULTS: Baseball players could achieve high DVA with significantly faster eye movement at shorter latencies than nonplayers. There was no difference in the ability to perceive moving object's images projected onto the retina between baseball players and nonplayers. CONCLUSIONS: These results suggest that the better DVA of baseball players is primarily due to a better ability to track moving objects with their eyes rather than to improved perception of moving images on the retina. This skill is probably obtained through baseball training.

Origins of superior dynamic visual acuity in baseball players: superior eye movements or superior image processing.

Dynamic visual acuity (DVA) is defined as the ability to discriminate the fine parts of a moving object. DVA is generally better in athletes than in non-athletes, and the better DVA of athletes has been attributed to a better ability to track moving objects. In the present study, we hypothesized that the better DVA of athletes is partly derived from better perception of moving images on the retina through some kind of perceptual learning. To test this hypothesis, we quantitatively measured DVA in baseball players and non-athletes using moving Landolt rings in two conditions. In the first experiment, the participants were allowed to move their eyes (free-eye-movement conditions), whereas in the second they were required to fixate on a fixation target (fixation conditions). The athletes displayed significantly better DVA than the non-athletes in the free-eye-movement conditions. However, there was no significant difference between the groups in the fixation conditions. These results suggest that the better DVA of athletes is primarily due to an improved ability to track moving targets with their eyes, rather than to improved perception of moving images on the retina.

A Japanese case of eosinophilic esophagitis.

Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophilia and an increased serum immunoglobulin E level. Computed tomography showed diffuse severe thickening of the esophageal wall, and a barium esophagogram revealed a small caliber of the middle and lower portion of the esophagus, without normal peristaltic contractions. Endoscopy of the esophagus showed a pale mucosa, with adherent whitish exudates resembling fungal infection, and prominent ring-like contractions. Histologic examination of a biopsy specimen revealed marked eosinophil infiltration into the esophageal mucosa. Endoscopic ultrasonography (EUS) demonstrated marked circumferential thickening of the esophageal submucosal layer, and an esophageal manometry study showed a high percentage of ineffective esophageal peristalsis and high-amplitude esophageal body contractions. EUS findings showed no change even after oral corticosteroid therapy, although the histological findings were improved. This is thought to be the first documented Japanese case of EE. EE should be considered in the differential diagnosis in cases of esophageal motility disturbance, even if the patients do not complain of dysphagia.

Three-dimensional electromagnetic articulography: a measurement principle.

A measurement principle of the three-dimensional electromagnetic articulographic device is presented. The state of the miniature receiver coil is described by five variables representing the position in the three-dimensional coordinate system and the rotation angles relative to it. When the receiver coil is placed in the magnetic field produced from the distributed transmitter coils, its state can be optimally estimated by minimizing the difference between the measured strength of the received signal and the predicted one using the known spatial pattern of the magnetic field. Therefore, the design and calibration of the field function inherently determine the accuracy in estimating the state of the receiver coil. The field function in our method is expressed in the form of a multivariate B spline as a function of position in the three-dimensional space. Because of the piecewise property of the basis function and the freedom in the selection of the rank and the number of basis functions, the spline field function has a superior ability to flexibly and accurately represent the actual magnetic field. Given a set of calibration data, the spline function is designed to form a smooth curved surface interpolating all of these data samples. Then, an iterative procedure is employed to solve the nonlinear estimation problem of the receiver state variables. Because the spline basis function is a polynomial, it is also shown that the calculation of the Jacobian or Hessian required to obtain updated quantities for the state variables can be efficiently performed. Finally, experimental results reveal that the measurement accuracy is about 0.2 mm for a preliminary condition, indicating that the method can achieve the degree of precision required for observing articulatory movements in a three-dimensional space. It is also experimentally shown that the Marquardt method is a better nonlinear programming technique than the Gauss-Newton or Newton-Raphson method for solving the receiver state problem.

Dynamical simulation of speech cooperative articulation by muscle linkages.

Different kinds of articulators, such as the upper and lower lips, jaw, and tongue, are precisely coordinated in speech production. Based on a perturbation study of the production of a fricative consonant using the upper and lower lips, it has been suggested that increasing the stiffness in the muscle linkage between the upper lip and jaw is beneficial for maintaining the constriction area between the lips (Gomi et al. 2002). This hypothesis is crucial for examining the mechanism of speech motor control, that is, whether mechanical impedance is controlled for the speech motor coordination. To test this hypothesis, in the current study we performed a dynamical simulation of lip compensatory movements based on a muscle linkage model and then evaluated the performance of compensatory movements. The temporal pattern of stiffness of muscle linkage was obtained from the electromyogram (EMG) of the orbicularis oris superior (OOS) muscle by using the temporal transformation (second-order dynamics with time delay) from EMG to stiffness, whose parameters were experimentally determined. The dynamical simulation using stiffness estimated from empirical EMG successfully reproduced the temporal profile of the upper lip compensatory articulations. Moreover, the estimated stiffness variation significantly contributed to reproduce a functional modulation of the compensatory response. This result supports the idea that the mechanical impedance highly contributes to organizing coordination among the lips and jaw. The motor command would be programmed not only to generate movement in each articulator but also to regulate mechanical impedance among articulators for robust coordination of speech motor control.

Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation.

Pleiotropic effects of statins, which are independent of lipid lowering, have been reported. In the present study, we examined the effect of a statin on apoptosis of adult rat cultured cardiac myocytes. We used the protein kinase C (PKC) inhibitors staurosporine (1 micro mol/L), chelerythrine (10 micro mol/L) and rottlerin (5 micro mol/L) to induce myocyte apoptosis. The effect of atorvastatin (10(-7) g/mL), a statin, on myocyte apoptosis induced by these PKC inhibitors was examined. All these PKC inhibitors markedly increased the percentage of terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL)-positive myocytes. This increase was significantly suppressed by atorvastatin treatment. Both chelerythrine and rottlerin induced subcellular translocation of PKCdelta and elevated caspase-3 activity in myocytes. The changes in the subcellular distribution of PKCdelta and caspase-3 activity induced by these PKC inhibitors were suppressed by atorvastatin treatment. The results of the present study suggest that the inhibitory effect of atorvastatin on apoptosis of adult rat cardiac myocytes induced by the PKC inhibitors is through activation of PKCdelta pathway.

Electromagnetic articulograph based on a nonparametric representation of the magnetic field.

Electromagnetic articulograph (EMA) devices are capable of measuring movements of the articulatory organs inside and outside the vocal tract with fine spatial and temporal resolutions, thus providing useful articulatory data for investigating the speech production process. The position of the receiver coil is detected in the EMA device on the basis of a field function representing the spatial pattern of the magnetic field in relation to the relative positions of the transmitter and receiver coils. Therefore, the design and calibration of the field function are quite important and influence the accuracy of position detection. This paper presents a nonparametric method for representing the magnetic field, and also describes a method for determining the receiver position from the strength of the induced signal in the receiver coil. The field pattern in this method is expressed by using a multivariate spline as a function of the position in the device's coordinate system. Because of the piecewise property of the basis functions and the freedom in the selection of the rank and the number of the basis functions, the spline function has a superior ability to flexibly and accurately represent the field pattern, even when it suffers from fluctuations caused by the interference between the transmitting channels. The position of the receiver coil is determined by minimizing the difference between the measured strength of the received signal and the predicted one from the spline representation of the magnetic field. Experimental results show that the error in estimating the receiver position is less than 0.1 mm for a 14 x 14-cm measurement area, and this error can be further reduced by using a spline-smoothing technique.