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Objective To analyze the characteristics and the differences of body composition in Yi of Sichuan, Guizhou and Yunnan. Methods Stature, body mass and body composition of 1556 Yi(male 757 case, famale 799 case) adults from Sichuan, Guizhou and Yunnan were investigated based on Anthropometric Method and the standard of Tanita company. Results The body mass index and percent body fat of Yi nationality people from Sichuan were significantly higher than that of those from Yunnan and Guizhou. The overall muscle and limb muscles of Yi nationality people from Sichuan were more developed than that of those from Sichuan and Yunnan. Yi nationality people from Sichuan, Yunnan and Guizhou all had the characters that muscle mass in right limb was higher than that in left. Conclusion Yi nationality people from Sichuan, Yunnan and Guizhou have great difference in body composition because of the diet and labour intensity.
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Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid. Preliminary studies show that the neogambogic acid can selectively inhibit the growth of various cancer cells, and has a broader antitumor activity and lower toxicity than gambogic acid. In this review, we summarize the advances made in the investigation of the anti-tumor effect of neogambogic acid in recent years.
Assuntos
Animais , Humanos , Antineoplásicos Fitogênicos , Química , Garcinia , Química , Neoplasias , Tratamento Farmacológico , Extratos Vegetais , Química , Xantenos , QuímicaRESUMO
Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid. Preliminary studies show that the neogambogic acid can selectively inhibit the growth of various cancer cells, and has a broader antitumor activity and lower toxicity than gambogic acid. In this review, we summarize the advances made in the investigation of the anti-tumor effect of neogambogic acid in recent years.
Assuntos
Animais , Humanos , Antineoplásicos Fitogênicos , Química , Garcinia , Química , Neoplasias , Tratamento Farmacológico , Extratos Vegetais , Química , Xantenos , QuímicaRESUMO
<p><b>BACKGROUND</b>Platinum-based chemotherapeutics are the most common regimens for advanced non-small-cell lung cancer (NSCLC) patients, and genetic factors are thought to represent important determinants of drug efficacy. We prospectively assessed the status of the XPC Ala499Val and Lys939Gln gene polymorphisms and investigated whether these SNPs can predict the response to cisplatin/carboplatin-based regimens in advanced NSCLC patients in a Chinese population.</p><p><b>METHODS</b>The treatment outcomes of 96 advanced NSCLC patients who were treated with platinum-based chemotherapy were evaluated. The polymorphic status of xeroderma pigmentosum group C (XPC) gene was genotyped by the 3-D polyacrylamide gel-based DNA microarray method.</p><p><b>RESULTS</b>The distributions of XPC Lys939Gln genotypes differed significantly between the response group (complete + partial responses) and the non-response group (stable + progressive disease; P = 0.022). The heterozygous A/C genotype carriers had a poorer response rate than the wild A/A genotype carriers in stage III (OR, 0.074; 95%CI, 0.008 - 0.704; P = 0.023). The XPC Ala499Val polymorphisms were not associated with response to platinum-based chemotherapy.</p><p><b>CONCLUSION</b>Polymorphisms of the XPC gene, Lys939Gln, may be a predictive marker of treatment response for advanced NSCLC patients in stage III.</p>
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Alelos , Protocolos de Quimioterapia Combinada Antineoplásica , Usos Terapêuticos , Carboplatina , Carcinoma Pulmonar de Células não Pequenas , Tratamento Farmacológico , Genética , Patologia , Cisplatino , Proteínas de Ligação a DNA , Genética , Genótipo , Neoplasias Pulmonares , Tratamento Farmacológico , Genética , Patologia , Estadiamento de Neoplasias , Polimorfismo de Nucleotídeo Único , Estudos ProspectivosRESUMO
Biodegradation of methyl parathion (MP), a widely used organophosphorus pesticide, was investigated using a newly isolated bacterium strain Acinetobacter radioresistens USTB-04. MP at an initial concentration of 1200 mg/L could be totally biodegraded by A. radioresistens USTB-04 as the sole carbon source less than 4 d in the presence of phosphate and urea as phosphorus and nitrogen sources, respectively. Biodegradation of MP was also achieved using cell-free extract of A. radioresistens USTB-04. MP at an initial concentration of 130 mg/L was completely biodegraded in 2 h in the presence of cell-free extract with a protein concentration of 148.0 mg/L, which was increased with the increase of pH from 5.0 to 8.0. Contrary to published reports, no intermediate or final degradation metabolites of MP could be observed. Thus we suggest that the cleavage of C-C bond on the benzene ring other than P-O bond may be the biodegradation pathway of MP by A. radioresistens USTB-04.
