Heat-clearing and Toxicity-removing Therapy for the Treatment of Acute Coronary Syndrome: An Observation of 55 Cases / 广州中医药大学学报

[Objective] To observe the preventive effect and mechanism of heat-clearing and toxicity-removing therapy for the treatment of acute coronary syndrome (ACS), and to explore the relationship of ACS with inflammation. [Methods] Fifty five ACS patients were randomized into 2 groups:41 patients in group A were treated with Sanhuang Tablets (mainly composed of Radix et Rhizoma Rhei, Radix Scutellariae and Rhizoma Coptidis) p.o., 4 tablets one time, twice a day, and a routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia; 14 patients in group B were given routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia. The treatment course lasted 2 weeks. After treatment, improvement in symptoms such as chest pain, chest distension, short breath, palpitation, fever, spontaneous sweating, insomnia, lassitude, aversion to cold and cold limbs was compared between group A and group B by scoring method. Meanwhile, inflammatory indicators in the two groups were also observed before and after treatment. [Results] The decrease in symptom scores, as well as the decrease in blood C-reactive protein (CRP) , tumor necrosis factor a (TNF-?) and interleukin 6 (IL-6) , was obvious in group A than that in group B (P

Relationship of Phlegm and Blood-stasis Syndrome in Coronary Heart Disease with Gene Polymorphism of Apolipoprotein E / 广州中医药大学学报

Objective To explore the relationship of apolipoprotein E(ApoE) and its gene polymorphism with phlegm and blood stasis syndrome in patients with coronary heart disease(CHD).Methods Ninety-seven qualified CHD patients involving phlegm syndrome(PS),blood-stasis syndrome(BSS),and phlegm and blood stasis syndrome(PBSS) were adopted.Thirty-five healthy volunteers were enrolled into the control group.Serum ApoE level was examined in all of the subjects,and their whole blood DNA were extracted for the detection of ApoE gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Correlation analysis of the data was performed with SPSS11.0 software.Results The difference of diabetes mellitus,smoking,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) was significant between CHD patients and healthy volunteers(P

Effect of Xiangdan Injection in Treating Acute Coronary Syndrome and Inflammatory Markers / 中药新药与临床药理

Objective To explore the relationship between acute coronary syndrome(ACS) and inflammation , and to observe the short-term effect of Xiangdan Injection(XI) in treating ACS and on inflammatory markers.Methods One hundred and twenty cases of ACS were randomized into two groups: 90 cases in treatment group and 30 in control group. All of the patients received the routine treatment, and the treatment group treated with XI additionally. The therapeutic effect was observed and plasma contents of inflammatory markers such as C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor ?(TNF-?) were detected before and after treatment.Results The effect of treatment group was better than that of the control group(P