1.
Ann N Y Acad Sci
; 987: 1-8, 2003 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12727618
RESUMO
Activation-induced cytidine deaminase (AID), a putative RNA-editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes-namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA-editing activity of AID.