1.
Org Lett
; 21(5): 1258-1262, 2019 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30767544
RESUMO
A pioneering chemiluminescent molecule reported by Schaap and co-workers, 3-(2'-spiroadamantane)-4-methoxy-4-(3â³-hydroxy)phenyl-1,2-dioxetane (AMPD), does not require enzymatic activation but is unsuitable for use under physiological conditions. To overcome this limitation, we have developed a new AMPD derivative that contains an acetamido group at the ortho position of the hydroxy group as an intramolecular hydrogen-bonding site in order to lower the p Ka value. This compound exhibits a superior chemiluminescence response to AMPD in the physiologically relevant pH range.