[Frontal mass simulating lipoma as a clinical presentation of prostatic adenocarcinoma]. / Bultoma frontal simulando lipoma como manifestación de adenocarcinoma de próstata.

OBJECTIVE: To report one case of metastatic prostatic carcinoma with a gaudy presentation as a lump which resulted to be a cutaneous metastasis. METHODS: We describe the debut in a patient, who thanks to the pathologic analysis of a lesion mimicking a lipoma, which was reported as adenocarcinoma, was worked up for prostatic adenocarcinoma and diagnosis was reached. We performed a bibliographic review using an electronic bibliographic search in PubMed (MEDLINE) using the terms "Prostatic Neoplasm" (MesH) AND "Neoplasm Metastasis" (MesH) AND "cutaneous" (free text). Most publications are case reports reviewing the probable dissemination way and localization. RESULTS: Positive immunohistochemical staining for PSA confirmed the origin of the metastasis, although PSA value did not offer doubts due to its value over 1100 ng/ml. Regarding the bibliographic search we obtained more than 26 papers, and selected only 8 that were adjusted to the objectives of our work. Cutaneous metastasis of prostatic origin appear in less than 0.3% of the cases, because bone, lymph node, and visceral disease are more frequent. Cases appearing during the evolution of the disease and metastasis after laparoscopic procedures are described. CONCLUSIONS: Cutaneous metastases of prostatic adenocarcinoma are very rare, but even rarer is it being the debut of the disease.

[Diagnostic and therapeutic management of renal hydatidosis]. / Manejo diagnóstico y terapéutico de la hidatidosis renal.

OBJECTIVE: Renal hydatidosis is caused by Echinococcus granulosus and is extremely rare, accounting for 3-4% of the cases of hydatidosis, being the third site after liver and lungs. It generally remains asymptomatic for years and the most frequent symptoms are pain, feeling of flank heaviness, and dysuria. In front of a compatible clinical picture, we studied the diagnostic, therapeutic, and follow-up schemes reviewing the literature. METHODS: We performed an electronic bibliographic search in PubMed (MEDLINE) which MESH terms "Echinococcosis" [MeSH] AND "urinary tract" [MeSH] and bibliographic citations. We perform a review on epidemiology, vital cycle of the parasite and management of patients with hydatidosis. Most published papers correspond to case reports from different localisations, although we found some reviews. RESULTS: We found a total of 137 papers, we selected 23 of them because they were related; five were reviews, but we only include 10 of them in our references. Although most were case reports, the reviews analyse the cycle of the Echinococcus and its various host sites (organs) in the human host. The human being may become an intermediary host through contact with the definitive host (dogs) or by taking contaminated water or vegetables. CONCLUSIONS: Thanks to the combination of history, imaging tests and serology we get close to the diagnosis in up to 80%. In many cases conservative surgery is possible, but after suspicion we should always sterilise with albendazole before surgical treatment, and monitor serum titles of anti-Echinococcus antibodies.

Bultoma frontal simulando lipoma como manifestación de adenocarcinoma de próstata / Frontal mass simulating lipoma as a clinical presentation of prostatic adenocarcinoma

OBJETIVO: Presentar un caso llamativo por la forma de presentación de un carcinoma de próstata metastátizado con la aparición de un “bultoma” que correspondía a una metástasis cutánea.MÉTODOS: Describimos la forma de debút de un paciente que gracias al análisis de la lesión que informó de un adenocarcinoma, que aparentaba un Lipoma, se investigó la posibilidad de ser un adenoca de próstata y se estableció el diagnóstico.Se ha realizado una revisión de la literatura mediante una búsqueda bibliográfica electrónica en PubMed (MEDLINE) utilizando los términos “Prostatic Neoplasm”(MesH) AND “Neoplasm Metastasis” (MesH) AND “cutaneous”(texto libre). La gran mayoría de las publicaciones corresponden a aportación de casos nuevos con revisión de la probable vía de diseminación y la localización.RESULTADOS: La tinción inmunohistoquímica con PSA positiva fue la que confirmó el origen de la Metástasis, aunque el valor del PSA no ofrecía dudas por valor superior a 1100 ng/ml. En relación con la búsqueda obtenemos mas de 26 trabajos, seleccionando para nuestra trabajo sólo 8 ya que se ajustan al objetivo del mismo. La aparición de metástasis cutáneas con origen prostático es inferior al 0,3%, ya que es mas frecuente la afectación ósea, en ganglios y visceras. Se describen casos en la evolución de la enfermedad y metástasis tras procedimientos laparoscópicos.CONCLUSIONES: La metástasis cutánea de una adenocarcinoma de próstata es muy rara, pero más aún que ésta sea el debut de la enfermedad (AU)

OBJECTIVE: To report one case of metastatic prostatic carcinoma with a gaudy presentation as a lump which resulted to be a cutaneous metastasis.METHODS: We describe the debut in a patient, who thanks to the pathologic analysis of a lesion mimicking a lipoma, which was reported as adenocarcinoma, was worked up for prostatic adenocarcinoma and diagnosis was reached.We performed a bibliographic review using an electronic bibliographic search in PubMed (MEDLINE) using the terms “Prostatic Neoplasm” (MesH) AND “Neoplasm Metastasis” (MesH) AND “cutaneous” (free text). Most publications are case reports reviewing the probable dissemination way and localization.RESULTS: Positive immunohistochemical staining for PSA confirmed the origin of the metastasis, although PSA value did not offer doubts due to its value over 1100 ng/ml. Regarding the bibliographic search we obtained more than 26 papers, and selected only 8 that were adjusted to the objectives of our work. Cutaneous metastasis of prostatic origin appear in less than 0.3% of the cases, because bone, lymph node, and visceral disease are more frequent. Cases appearing during the evolution of the disease and metastasis after laparoscopic procedures are described.CONCLUSIONS: Cutaneous metastases of prostatic adenocarcinoma are very rare, but even rarer is it being the debut of the disease (AU)

Manejo diagnóstico y terapéutico de la hidatidosis renal / Diagnostic and therapeutic management of renal hydatidosis

OBJETIVO: La hidatidosis renal está causado por Echinococcus granulosus y es extremadamente infrecuente, constituyendo el 3-4% de los casos de hidatidosis, siendo la tercera localización tras el hígado y pulmones. Habitualmente permanece asintomático durante años y los síntomas más comunes son dolor, sensación de pesadez en flanco y disuria. Ante la aparición de un cuadro compatible, estudiamos la pauta diagnóstica, terapéutica y de seguimiento revisando la literatura.MÉTODOS: Realizamos una búsqueda bibliográfica electrónica PubMed (MEDLINE) con términos MESH “Equinococcosis”[MeSH] AND “Urinary Tract”[MeSH] y de citas bibliográficas. Hacemos una revisión de la epidemiología, el ciclo vital del parásito y del manejo del paciente afecto de Hidatidosis. La gran mayoría de las publicaciones corresponden a aportación de casos con diferentes localizaciones, aunque encontramos algunas revisiones.RESULTADOS: Encontramos un total de 137 trabajos de los cuales, seleccionamos veintitres por estar relacionados; cinco correspondían a revisiones, referenciamos en el texto sólo diez. Aunque la mayoría son aportación de casos, las revisiones analizan el ciclo del Echinococcus y los diferentes lugares de asentamiento (órganos) en el huésped hombre. El hombre puede llegar a ser huésped intermedio a través de contacto con huésped definitivo (perros...) o por ingesta de agua contaminada o vegetales.CONCLUSIONES: Gracias a la combinación de anamnesis, estudios de imagen y serología nos aproximamos al diagnóstico hasta en un 80%. En muchos casos es posible la cirugía conservadora pero tras la sospecha debemos siempre esterilizar con Albendazol antes del tratamiento quirúrgico y tras el tratamiento monitorizar mediante serología la titulación de Anticuerpos anti-echinococcus(AU)

OBJECTIVE: Renal hydatidosis is caused by Echinococcus granulosus and is extremely rare, accounting for 3-4% of the cases of hydatidosis, being the third site after liver and lungs. It generally remains asymptomatic for years and the most frequent symptoms are pain, feeling of flank heaviness, and dysuria. In front of a compatible clinical picture, we studied the diagnostic, therapeutic, and follow-up schemes reviewing the literature.METHODS: We performed an electronic bibliographic search in PubMed (MEDLINE) which MESH terms “ Echinococcosis”[MeSH] AND “urinary tract”[MeSH] and bibliographic citations. We perform a review on epidemiology, vital cycle of the parasite and management of patients with hydatidosis. Most published papers correspond to case reports from different localisations, although we found some reviews.RESULTS: We found a total of 137 papers, we selected 23 of them because they were related; five were reviews, but we only include 10 of them in our references. Although most were case reports, the reviews analyse the cycle of the Echinococcus and its various host sites (organs) in the human host. The human being may become an intermediary host through contact with the definitive host (dogs) or by taking contaminated water or vegetables.CONCLUSIONS: Thanks to the combination of history, imaging tests and serology we get close to the diagnosis in up to 80%. In many cases conservative surgery is possible, but after suspicion we should always sterilise with albendazole before surgical treatment, and monitor serum titles of anti- Echinococcus antibodies(AU)

[Voiding symptoms as presentation of an intravesical foreign body]. / Clínica miccional como síntoma por cuerpo extraño intravesical.

OBJECTIVES: The presence of intravesical foreign bodies is exceptional; it is not a common emergency. Most foreign bodies have a sexual-erotic origin, although we cannot forget others such as elements left by the surgeon in the surgical field. We performed a bibliographic review on the topic. METHODS: We performed a PubMed (MEDLINE) electronic bibliographic search with the mesh terms "foreign-body migration" [MESH] AND "Urinary Bladder" [MESH] and bibliographic citations. We performed a bibliographic review establishing a classification depending on the origin and diagnosis, as well as treatment. Most publications are case reports. We described the most frequent presentation which was the same than we have in our Center. RESULTS: We found a total of 122 works, nine of which were reviews; we selected 20 works. Although most are case reports, the reviews establish a classification depending on the origin: so, they refer to those foreign bodies directly introduced into the bladder: 1. By the patient: hairpins, safety pins, pencils, copper wires, hairs; 2. Accidentally: bullets; 3. Iatrogenic: fragments of bladder or ureteral catheters, staples, sutures. Foreign bodies migrated from other places: urological, gynecological, gastrointestinal, or vascular origin. We established a diagnostic and therapeutic algorithm. CONCLUSIONS: Bladder foreign bodies are not as frequent as it is believed. Most are found incidentally. Lower urinary tract symptoms are the most frequent, as the antecedent of manipulation by the patient or others in the genital-urologic sphere. The treatment of choice is extraction using the least invasive and most simple method for the patient.

Clínica miccional como síntoma por cuerpo extraño intravesical / Voiding symptoms as presentation of an intravesical foreign body

OBJETIVO: La presencia de cuerpos extraños intravesicales aparecen excepcionalmente, no siendo una urgencia habitual. La mayoría de cuerpos extraños son de origen erótico-sexual aunque no podemos olvidar otros como el abandono en el campo quirúrgico de algún elemento utilizado. A propósito de ello, revisamos la literatura. MÉTODOS: Realizamos una búsqueda bibliográfica electrónica PubMed (MEDLINE) con términos MESH «Foreign-Body Migration» [MeSH] AND «Urinary Bladder» [MeSH] y de citas bibliográficas. Hacemos una revisión de la literatura estableciendo una clasificación atendiendo al origen y diagnóstico así como tratamiento. La gran mayoría de las publicaciones corresponden a aportación de casos nuevos. Describimos la forma de presentación más habitual que coincidía con el que tuvimos en nuestro Centro. RESULTADOS: Encontramos un total de 122 trabajos de los cuales nueve correspondían a una revisión; seleccionamos en total 20. Aunque la mayoría son aportación de casos, las revisiones, establece una clasificación en función del origen: así, hacen referencia a los introducidos directamente a la vejiga: -por la propia persona: horquillas, imperdibles, lápices, hilos de cobre, pelos; -accidentales: balas; -iatrógenos: fragmentos de sonda o catéteres, grapas, suturas. Migrados desde otros lugares:de origen urológicos, ginecológico, digestivo, vascular. Estableceremos un algoritmo diagnóstico y terapéutico. CONCLUSIONES: Los cuerpos extraños dentro de la vejiga no son tan infrecuentes como se cree. El hallazgo casual es lo más frecuentes. Los síntomas urinarios son los mas frecuentes y el antecedente de manipulación propia o de otros en esa esfera genito urológica y el tratamiento es la extracción utilizando el menos cruento y mas sencillo para el paciente (AU)

OBJECTIVES: The presence of intravesical foreign bodies is exceptional; it is not a common emergency. Most foreign bodies have a sexual-erotic origin, although we cannot forget others such as elements left by the surgeon in the surgical field. We performed a bibliographic review on the topic. METHODS: We performed a PubMed (MEDLINE) electronic bibliographic search with the mesh terms «foreign-body migration» [MESH] AND «Urinary Bladder» [MESH] and bibliographic citations. We performed a bibliographic review establishing a classification depending on the origin and diagnosis, as well as treatment. Most publications are case reports. We described the most frequent presentation which was the same than we have in our Center. RESULTS: We found a total of 122 works, nine of which were reviews; we selected 20 works. Although most are case reports, the reviews establish a classification depending on the origin: so, they refer to those foreign bodies directly introduced into the bladder: 1. By the patient: hairpins, safety pins, pencils, copper wires, hairs; 2. Accidentally: bullets; 3. Iatrogenic: fragments of bladder or ureteral catheters, staples, sutures. Foreign bodies migrated from other places: urological, gynecological, gastrointestinal, or vascular origin. We established a diagnostic and therapeutic algorithm. CONCLUSIONS: Bladder foreign bodies are not as frequent as it is believed. Most are found incidentally. Lower urinary tract symptoms are the most frequent, as the antecedent of manipulation by the patient or others in the genital-urologic sphere. The treatment of choice is extraction using the least invasive and most simple method for the patient (AU)

[Metachronic testicular tumor secondary to invasive bladder carcinoma]. / Tumor testicular metacronico secundario a carcinoma vesical infiltrante.

OBJECTIVE: To report a rare case of testicular metastasis secondary to an infiltrative transitional cell carcinoma years after radical surgery. CASE REPORT: 71-year-old male patient with history of infiltrative bladder tumor, status post radical cystoprostatectomy with urethrectomy. Seven years after surgery he presents with pain and swelling in the right testicle. Inguinal orchyectomy was carried out with the pathologic diagnosis of testicular metastasis of a high-grade transitional cell carcinoma. We perform a bibliographic review. RESULTS: The patient is disease-free twelve months after orchyectomy. CONCLUSIONS: Apart from leukemia and lymphoma, testicular metastases are extremely rare. The existence of testicular metastases means a metastatic dissemination to other organs, therefore chemotherapy could improve prognosis.

Tumor testicular metacrónico secundario a carcinoma vesical infiltrante / Metachronic testicular tumor secondary to invasive bladder carcinoma

OBJETIVOS: Presentar un caso raro de metástasis testicular secundaria a carcinoma urotelial infiltrante años después de practicada cirugía radical. METODOS: Exposición del caso clínico: paciente de 71 años sometido a cistoprostatectomía radical con uretrectomía por tumor vesical infiltrante. A los siete años debuta con dolor y aumento del tamaño testicular derecho. Se le practicó orquiectomía por vía inguinal siendo diagnosticado de metástasis testicular de carcinoma vesical de alto grado. y revisión de la literatura publicada al respecto. RESULTADOS: Supervivencia libre de enfermedad a los 12 meses de la orquiectomía. CONCLUSIONES: El tumor testicular metastático excluyendo leucemias y linfomas es extremadamente raro. La presencia de metástasis testiculares supone una diseminación metastásica a otros niveles y por ello la Quimioterapia podría mejorar el pronóstico (AU)

OBJECTIVE: To report a rare case of testicular metastasis secondary to an infiltrative transitional cell carcinoma years after radical surgery. METHODS: Case Report: 71-year-old male patient with history of infiltrative bladder tumor, status post radical cystoprostatectomy with urethrectomy. Seven years after surgery he presents with pain and swelling in the right testicle. Inguinal orchyectomy was carried out with the pathologic diagnosis of testicular metastasis of a high-grade transitional cell carcinoma. We perform a bibliographic review. RESULTS: The patient is disease-free twelve months after orchyectomy. CONCLUSIONS: Apart from leukemia and lymphoma, testicular metastases are extremely rare. The existence of testicular metastases means a metastatic dissemination to other organs, therefore chemotherapy could improve prognosis

[Dorsal onlay urethroplasty with foreskin mucosa free graft (Barbagli's technique): preliminary results of our case series]. / Uretroplastia dorsal con injerto libre de mucosa prepucial (técnica de Barbagli): resultados preliminares de nuestra serie.

OBJECTIVES: We evaluate the indication and results in the treatment of complex urethral stenosis by the Barbagli's technique. METHODS: We retrospectively review 8 patients undergoing dorsal onlay urethroplasty with foreskin mucosa free graft. We analyze their preoperative characteristics. Mean stenosis length was 6.25 cm and the site was bulbar urethra in seven cases and penile in one. Mean preoperative flow was 8.78 ml/sec. We describe the technique and present our results. RESULTS: There are 87.5% of goods results (cure of the stenosis) with 22 months of mean follow-up. Only one patient required a second operation (end to end anastomosis) with good outcome. CONCLUSIONS: The dorsal onlay urethroplasty with foreskin mucosa free graft is an effective technique in long and complex urethral stenosis, and we consider it the technique of first choice in view of our results.

[Metachronous adrenal metastasis in two patients undergoing radical nephrectomy for primary renal cell carcinoma]. / Metástasis suprarrenal metacrónica en 2 pacientes sometidos a nefrectomía radical por carcinoma de células renales primario.

OBJECTIVES: We report two exceptional cases of metachronous adrenal metastasis of renal cell carcinomas and perform a bibliographic review. After the evaluation of various features such as frequency, etiopathogenesis, diagnosis and follow-up of these patients we conclude that these metastases are rare, and they usually appear late in the evolution of patients with low stage renal cell carcinoma. RESULTS/CONCLUSIONS: Once reviewed the treatment and checked the absence of guidelines for the therapeutic management of these patients we propose surgery for the adrenal metastasis as well as adjuvant treatment with immunotherapy.

Uretroplastia dorsal con injerto libre de mucosa prepucial (Técnica de Barbagli): resultados preliminares de nuestra serie) / Dorsal onlay urethroplasty with foreskin mucosa free graft (Barbagli´s technique): preliminary results of our case series

OBJETIVO: Valoramos la indicación y nuestros resultados en el tratamiento de la estenosis de uretra compleja mediante la Técnica de Barbagli.MÉTODO: Realizamos una revisión retrospectiva de 8 pacientes a los que se indica la uretroplastia dorsal con injerto de mucosa libre prepucial. Analizamos las característicaspreoperatorias de los pacientes. La longitud media de la estenosis fue de 6,25 cm, la localización bulbar en 7 casos y peneana en uno. El flujo medio obtenido en la flujometría preoperatoria fue de 8,78 ml/seg. Describimos la técnica y presentamos los resultadosobtenidos con la misma. RESULTADOS: Con un tiempo medio de seguimiento de 22 meses tenemos un 87,5% de buenos resultados, entendiendo estos como la resolución definitiva de la estenosis. Sólo 1 paciente ha precisado un nuevo tratamientoquirúrgico (anastomosis término terminal), con buen resultado evolutivo.CONCLUSIONES: Concluimos que la uretroplastia dorsalcon injerto libre de mucosa prepucial es una técnica efectiva en estenosis de uretra larga y compleja y que por los resultados obtenidos, la consideramos técnica de primera elección en este tipo de estenosis uretrales

OBJECTIVES: We evaluate the indication and results in the treatment of complex urethral stenosis by the Barbagli`s technique.METHODS: We retrospectively review 8 patients undergoingdorsal onlay urethroplasty with foreskin mucosa free graft. We analyze their preoperative characteristics. Mean stenosis length was 6.25 cm and the site was bulbar urethra in seven cases and penile in one. Mean preoperative flow was 8.78 ml/sec. We describe the technique and present our results.RESULTS: There are 87.5% of goods results (cure of the stenosis) with 22 months of mean follow-up. Only one patient required a second operation (end to endanastomosis) with good outcome.CONCLUSIONS: The dorsal onlay urethroplasty with foreskin mucosa free graft is an effective technique in long and complex urethral stenosis, and we consider it the technique of first choice in view of our results

Metástasis suprarrenal metacrónica en 2 pacientes sometidos a nefrectomía radical por carcinoma de células renales primario / No disponible

OBJETIVOS/MÉTODOS: Presentamos dos casos excepcionales de metástasis suprarrenales metacrónicas de carcinoma de células renales y revisamos la literatura existente. Valorados distintos aspectos como la frecuencia, etiopatogenia, diagnóstico y seguimiento de estos pacientes concluimos que estas metástasis son poco frecuentes y suelen presentarse tardías en su evolución en pacientes con CCR con bajo estadios anatomopatológicos. RESULTADOS/CONCLUSIONES: Revisado el trata- miento y constatando que no hay directrices en cuanto al manejo terapéutico de estos pacientes con metástasis proponemos la cirugía de la metástasis suprarrenal así como el tratamiento adyuvante con inmunoterapia (AU)

OBJECTIVES: We report two exceptional cases of metachronous adrenal metastasis of renal cell carcinomas and perform a bibliographic review. After the evaluation of various features such as frequency, etiopathogenesis, diagnosis and follow-up of these patients we conclude that these metastases are rare, and they usually appear late in the evolution of patients with low stage renal cell carcinoma. RESULTS/CONCLUSIONS: Once reviewed the treatment and checked the absence of guidelines for the therapeutic management of these patients we propose surgery for the adrenal metastasis as well as adjuvant treatment with immunotherapy (AU)

[Malacoplakia within a female urethral diverticulum]. / Malacoplaquia en divertículo uretral femenino.

OBJECTIVES: We report one case of malakoplakia within a female urethral diverticulum. METHODS: 33-year-old patient who consulted for an asymptomatic vaginal tumor. Physical examination, blood and urine analysis and microbiology tests, as well as urethrocystoscopy and intravenous pyelogram were performed. With the diagnosis of urethral diverticulum we undertook surgical excision through a vaginal approach. RESULTS: Pathology revealed the typical characteristics of malakoplakia within the diverticular lumen. CONCLUSIONS: Malakoplakia is an infrequent inflammatory disease which involves the urinary tract in most cases. Urethra location is exceptional.

[Left adrenal carcinoma with caval thrombosis]. / Carcinoma suprarrenal izquierdo con trombo en cava.

OBJECTIVES: To review the epidemiology, classification, prognosis, and therapeutic options of adrenal cortical carcinoma, mainly those of functional tumors. METHODS AND RESULTS: 52-year-old male presenting with wasting syndrome and a big left adrenal tumor, as well as a possible inferior vena cava thrombus. The tumor was catalogued as non functional after functional studies. Surgical intervention was carried out including adrenal tumor excision, splenectomy, and cavotomy with thrombectomy of a tumoral thrombus coming from the left adrenal and renal veins. Infrarenal iliocaval thrombosis appeared during the postoperative period, requiring intensive anticoagulant therapy and ICU admission for control. Pathological diagnosis confirmed the existence of a high grade malignant adrenal cortical carcinoma. Patient died two months after surgery due to disease progression. CONCLUSIONS: Radiological tests are fundamental in the diagnosis of adrenal masses. In the case of big tumoral masses, it is important to rule out the existence of possible tumor thrombi in the adrenal vein territory, including the inferior vena cava.

Carcinoma suprarrenal izquierdo con trombo en cava / Left adrenal cortical carcinoma with caval thrombus

OBJETIVOS: Se revisan la epidemiología, clasificación, pronóstico y alternativas terapéuticas del carcinoma suprarrenal, fundamentalmente de las masas no funcionales. MÉTODOS Y RESULTADOS: Varón de 52 años con síndrome constitucional y gran tumoración suprarrenal izquierda, así como posible trombo en cava inferior. El estudio de funcionalidad catalogó a la masa como no funcional. Durante la intervención quirúrgica, se realizó extirpación de la masa adrenal, esplenectomía y trombectomía mediante cavotomía por trombo tumoral procedente de vena suprarrenal y renal izquierdas. En el postoperatorio sufrió cuadro de trombosis iliocava infrarrenal, que requiso tratamiento anticoagulante intensivo y control en UCI. El diagnóstico anatomopatológico confirmó la presencia de carcinoma suprarrenal de alto grado de malignidad. El paciente falleció a los dos meses de la intervención por progresión de la enfermedad. CONCLUSIONES: Las pruebas de imagen son fundamentales en el diagnóstico de las masas suprarrenales. En el caso de grandes masas es importante sospechar la posible presencia de trombos tumorales en el territorio venoso de la glándula adrenal, incluyendo la vena cava. El clampaje de la vena cava exige la instauración de tratamiento anticoagulante precoz a dosis terapéuticos. La cirugía es el único tratamiento que ha demostrado un aumento de la supervivencia (AU)