Cardiovascular and cerebrovascular-associated mortality in patients with preceding bronchiectasis exacerbation.

BACKGROUND: Bronchiectasis is associated with an increased incidence of atherosclerotic cardiovascular disease (ASCaVD) and atherosclerotic cerebrovascular disease (ASCeVD). Its effect on associated mortality is unclear. OBJECTIVES: This study investigated the effects of bronchiectasis exacerbation prior to ASCaVD or ASCeVD events on mortality in patients with bronchiectasis using a large population-based database. METHODS: A retrospective cohort of patients with bronchiectasis who experienced ASCaVD (n = 1066) or ASCeVD (n = 825) was studied for the first time using a nationwide population-based database (National Health Insurance Service-National Sample Cohort, Korea, 2002-2015). We classified each cohort according to the presence of moderate bronchiectasis exacerbation within 1 year before the ASCaVD or ASCeVD event. We evaluated 90-day, 1-year, and all-cause mortalities risk. RESULTS: Within 1 year before the index ASCaVD or ASCeVD event, 149 (13.9%) and 112 (13.6%) patients with bronchiectasis experienced moderate exacerbation(s), respectively. Mild exacerbations did not different in frequency between the survivors and nonsurvivors. In both cohorts, more nonsurvivors experienced moderate exacerbations than survivors. The odds ratios of 90-day and 1-year mortalities and hazard ratios of all-cause mortalities on experiencing moderate exacerbations were 2.27 [95% confidence interval (CI) = 1.26-4.10], 3.30 (95% CI = 2.03-5.38), and 1.78 (95% CI = 1.35-2.34) in the bronchiectasis-ASCaVD cohort and 1.73 (95% CI = 0.94-3.19), 1.79 (95% CI = 1.07-3.00), and 1.47 (95% CI = 1.10-1.95), in the bronchiectasis-ASCeVD cohort. CONCLUSION: Hospitalization or emergency room visit for bronchiectasis exacerbation within 1 year before ASCaVD or ASCeVD is associated with an increased ASCaVD- or ASCeVD-associated mortality.

Associations between asthma and body weight misconceptions among South Korean adolescents: Nationwide cross-section study.

Objectives: As the numbers of adolescents with asthma are increasing, appropriate recognition of the importance of body weight is necessary. This study explored body weight misconceptions and related factors in adolescent asthma patients. Methods: Web-based self-reported data from the Korean Youth Risk Behavior Web-Based Survey of 60,974 physician-diagnosed adolescents with asthma were used in this study. Self-reported questionnaires were employed to assess socioeconomic status, health behavior, and psychological factors. Multiple logistic regression after adjustment for confounding factors was used to explore body weight misconception. Results: A total of 28,771 (47.2%) respondents incorrectly classified their weight status, with 13,684 (22.5%) under-assessing and 15,087 (24.7%) over-assessing their weight. Body weight misconceptions were positively associated with middle school attendance (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.02-1.06), co-educational school attendance (OR 1.07, 95% CI 1.01-1.11), living without parents (OR 1.11, 95% CI 1.03-1.19), self-rated poor health status (OR 1.04, 95% CI 1.00-1.10), self-rated unhappiness (OR 1.15, 95% CI 1.09-1.20), moderate-to-severe stress (OR 1.14, 95% CI 1.11-1.18), depressive mood (OR 1.10, 95% CI 1.06-1.14), suicidal ideation (OR 1.09, 95% CI 1.04-1.13), and suicide attempts (OR 1.12, 95% CI 1.05-1.21); negatively associated with male gender (OR 0.86, 95% CI 0.83-0.89) and higher level academic achievement (OR 0.92, 95% CI 0.88-0.96), respectively. Conclusion: Negative psychological factors and school type were found to be associated with body weight misconceptions in adolescents with asthma. Our study shows that more efforts are needed to improve such misconceptions and to develop healthy behaviors in adolescents with asthma.