1.
Org Lett
; 7(17): 3765-8, 2005 Aug 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16092870
RESUMO
A novel family of BINAP ligands were prepared with alkoxy- and acetoxy-derived substituents in the 3,3'-positions. They were prepared through a convergent synthesis starting from readily available 4-bromo-2-naphthol. These ligands afforded excellent enantioselectivities in the asymmetric hydrogenation of substituted olefins. The presence of the 3,3'-substituents was shown to be beneficial by a direct comparison with the parent unsubstituted BINAP. [reaction: see text]