RESUMO
Background: Cervical cancer (CC) is the second most common type of female malignancy in Bangladesh. Polymorphisms in the CYP1A1 gene have been reported to be associated with CC in different populations. This case-control study with meta-analysis was undertaken to assess the relation of CYP1A1 rs4646903 and rs1048943 polymorphisms with the susceptibility of CC. Methods: A total of 185 CC patients and 220 controls were recruited, and the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) technique was applied for genotyping. Again, 42 eligible studies (24 with rs4646903 and 18 with rs1048943) were included for meta-analysis, and RevMan 5.3 and the MetaGenyo web-based tool were used. Results: The rs4646903 polymorphism was significantly linked with CC in all association models, namely, additive 1, additive 2, dominant, recessive, overdominant, and allele models (OR = 2.41, 4.75, 2.67, 3.61, 2.13, and 2.44 with corresponding 95% CI = 1.55-3.76, 1.81-12.45, 1.75-4.07, 1.39-9.35, 1.38-3.30, and 1.71-3.48, respectively). On the contrary, rs1048943 showed no association (p > 0.05) with CC. Haplotype analysis revealed AT and AC haplotypes significantly decreased (OR = 0.45) and increased (OR = 4.86) CC risk, respectively, and SNPs are in strong linkage disequilibrium (D' = 0.912, r2 = 0.448). Again, rs4646903 carriers with a contraception history and >5 years of taking contraceptives showed an enhanced risk of CC (OR = 2.39, OR = 3.05). Besides, rs1048943 carriers aged >40 years (OR = 0.44), conceived first child aged ≤18 years (OR = 3.45), and history of contraceptives (OR = 2.18) were significantly linked with CC. Our meta-analysis found that for CYP1A1 rs4646903 codominant 1 (COD 1), codominant 2 (COD 2), codominant 3 (COD 3), dominant model (DM), recessive model (RM), and allele model (AM) in Caucasians and overdominant model (OD) in the overall population are associated with an elevated risk of CC, whereas rs1048943 is also associated with CC in overall, Caucasians and Asians in some genetic models. Conclusion: Our case-control study and meta-analysis summarize that CYP1A1 rs4646903 and rs1048943 polymorphisms may be correlated with cervical cancer.
RESUMO
This research is concerned with understanding the factors behind the trade-off between child labor and child schooling, given the well-documented links between the two. It examines parents' behavior in their decision-making on their children's schooling or practicing child labor. Depending on qualitative research methods including 28 semi-structured interviews and two focus group discussions conducted in the rural areas of Bangladesh in 2020, this study reveals the following: subsistence needs compel households, particularly the ultra-poor and the female-headed, to trade off child labor with schooling; due to higher demand of labor, parents engage their children into work instead of schooling; parents of labor-intensive occupations tend to trade off child labor with schooling; sexual division of labor remains obvious; finally, credit constraints and cultural beliefs have negative impacts on parental decision-making on child schooling. Interventions aiming to reduce child labor and increase schooling in these rural areas must remain mindful of the socio-economic and cultural needs.
RESUMO
Conservation agriculture is considered as an agro-ecological approach to the sustainable and resource-saving crop production system. Previous studies on the adoption of agricultural innovation often consider socio-economic characteristics and overlook underlying psychological factors influencing farmers' behavioral intention. This study adopted three socio-psychological constructs, Attitude, Subjective Norm (SN), and Perceived Behavioral Control (PBC), which originated from the Theory of Planned Behavior (TPB), and proposed two new constructs, Knowledge (K) and Perceived Climatic Threats of Conventional Farming (PCTCV). Using the Extended Theory of Planned Behavior Model (ETPBM), this study analyzed factors affecting the intention of farmers to continue Conservation Agriculture (CA) for the following year (2020) in three districts located in the northern part of Bangladesh. This research found evidence from the hierarchical regression analysis that variables of ETPBM could explain 7% more variation (change in R2) in intention than variables of TPB, while the socio-economic characteristics of farmers can explain only 0.5% more than the variables of ETPBM. Structural Equation Modelling (SEM) was used to determine and examine the extended theory and indicated that farmers' knowledge (K) had the highest total impact, while attitude had the highest direct impact on intention. The results indicated that factors including Attitude, SN, PBC, Knowledge (K), and PCTCV are positively significant when attempting to understand farmers' intentions to adopt CA. This study presented evidence about the effectiveness of ETPBM when assessing the farmers' intentions towards conservation farming. Based on these findings, we concluded that the combination of extension services for upgrading the level of knowledge concerning the importance of CA could significantly affect farmers' attitudes on intention towards the application of CA.
