Leaking in Intimate Partner Homicide: A Systematic Review.

Intimate partner homicides (IPH) are serious offenses by a heterogeneous group of offenders with diverse risk factors that are too unspecific for the successful prediction of an offense. Recent research suggested several warning signs that may precede IPH and enhance its prevention, but little is still known about "leaking." Leaking comprises all offense-related statements, behaviors, or actions that express the perpetrator's thoughts, fantasies, ideas, interests, feelings, intentions, plans, or positive evaluations of an own violent act or previous similar offenses prior to the own attack. This review aims to identify the forms, recipients, and media of leaking as well as potential subgroup differences in cases of IPH. We identified 47 relevant publications via a systematic search of eight databases and additional methods. We included publications that did not explicitly use the term, but described behaviors that could be interpreted as leaking. Up to now, leaking has not been systematically researched in cases of IPH. Nevertheless, publications described several behaviors that are in line with our definition of leaking and were categorized into five broader categories: (a) homicide announcements, (b) previous severe acts of violence, (c) suicidal behavior, (d) planning activities, and (e) interest in similar offenses/offenders. Information on recipients and media as well as subgroup differences was sparse. Leaking is relevant in IPH, but more systematic research is needed to understand its potential role in future risk analyses procedures and prevention of IPH.

Orthorexic eating behaviour, illness anxiety and dysfunctional cognitions characteristic of somatic symptom disorders in a non-clinical sample.

PURPOSE: To analyse the relation of illness anxiety, dysfunctional cognitions characteristic of somatic symptom disorders and orthorexic eating behaviour in a non-clinical sample. METHODS: N = 445 participants (n = 363 females) completed an online survey with the following questionnaires: the Düsseldorf Orthorexia Scale to measure orthorexic eating behaviour, the Attitudes Towards Body and Health Questionnaire to assess dysfunctional cognitions concerning the perception and interpretation of bodily sensations and the Multidimensional Inventory of Hypochondriacal Traits to measure illness anxiety. RESULTS: In the total sample, orthorexic eating behaviour was associated with the aforementioned variables to a very low extent. However, individuals with high levels of orthorexic eating behaviour (n = 19) displayed significantly higher levels of health habits and of perceptions of autonomic sensations, as well as higher levels of hypochondriacal worry and absorption than individuals with low levels of orthorexic eating behaviour (n = 19). CONCLUSIONS: Orthorexic eating behaviour is associated to some characteristic features of illness anxiety and dysfunctional cognitions characteristic of somatic symptom disorders. Future studies should investigate whether illness anxiety serves as a risk factor for the development of orthorexic eating behaviour. LEVEL OF EVIDENCE: III, case-control analytic study.

Analysis of the CYC/TB1 class of TCP transcription factors in basal angiosperms and magnoliids.

Flower monosymmetry contributes to specialized interactions between plants and their insect pollinators. In the magnoliids, flower monosymmetry is exhibited only in the Aristolochiaceae (Piperales). Aristolochia flowers develop a calyx-derived monosymmetric perianth that enhances pollination success by a flytrap mechanism. Aristolochia arborea forms additionally a special perianth outgrowth that mimics a mushroom to attract flies, the mushroom mimicry structure (MMS). In core eudicots, members of the CYC2 clade of TCP transcription factors are key regulators of corolla monosymmetry establishment. The CYC2 clade arose via core eudicot-specific duplications from ancestral CYC/TB1 genes. CYC/TB1 genes are also thought to affect monosymmetry formation in early diverging eudicot and monocot species. Here, we demonstrate that CYC/TB1 genes, named CYC-like genes (CYCL) are present in basal angiosperms and magnoliids. Expression analyses in A. arborea indicate that CYCL genes participate in perianth and MMS differentiation processes and do not support a CYCL gene function in initial flower monosymmetry formation. Heterologous CYCL and CYC2 gene overexpression studies in Arabidopsis show that Aristolochia CYCL proteins only perform a CYC2-like function when the CYCL TCP domain is replaced by a CYC2 domain. Comparative TCP domain analyses revealed that an LxxLL motif, known to mediate protein-protein interactions, evolved in the second helix of the TCP domain in the CYC2 lineage and contributes to CYC2-related functions. Our data imply that divergent evolution of the CYC/TB1 lineages caused significant changes in their coding regions, which together with cis-regulatory changes established the key CYC2 function in regulating eudicot flower monosymmetry.

Differential transcriptome analysis reveals insight into monosymmetric corolla development of the crucifer Iberis amara.

BACKGROUND: In the co-evolution between insects and plants, the establishment of floral monosymmetry was an important step in angiosperm development as it facilitated the interaction with insect pollinators and, by that, likely enhanced angiosperm diversification. In Antirrhinum majus, the TCP transcription factor CYCLOIDEA is the molecular key regulator driving the formation of floral monosymmetry. Although most Brassicaceae form a polysymmetric corolla, six genera develop monosymmetric flowers with two petal pairs of unequal size. In the monosymmetric crucifer Iberis amara, formation of the different petal pairs coincides with a stronger expression of the CYC-homolog IaTCP1 in the small, adaxial petals. RESULTS: In this study, RNA-Seq was employed to reconstruct the petal transcriptome of the non-model species Iberis amara. About 9 Gb of sequence data was generated, processed and re-assembled into 18,139 likely Iberis unigenes, from which 15,983 showed high sequence homology to Arabidopsis proteins. The transcriptome gives detailed insight into the molecular mechanisms governing late petal development. In addition, it was used as a scaffold to detect genes differentially expressed between the small, adaxial and the large, abaxial petals in order to understand the molecular mechanisms driving unequal petal growth. Far more genes are expressed in adaxial compared to abaxial petals implying that IaTCP1 activates more genes than it represses. Amongst all genes upregulated in adaxial petals, a significantly enhanced proportion is associated with cell wall modification and cell-cell signalling processes. Furthermore, microarrays were used to detect and compare quantitative differences in TCP target genes in transgenic Arabidopsis plants ectopically expressing different TCP transcription factors. CONCLUSIONS: The increased occurrences of genes implicated in cell wall modification and signalling implies that unequal petal growth is achieved through an earlier stop of the cell proliferation phase in the small, adaxial petals, followed by the onset of cell expansion. This process, which forms the monosymmetric corolla of Iberis amara, is likely driven by the enhanced activity of IaTCP1 in adaxial petals.

Corolla monosymmetry: evolution of a morphological novelty in the Brassicaceae family.

Evolution of floral monosymmetry is thought to be a major driving force of angiosperm radiation, making angiosperms the most successful land plant group in terms of species richness. Monosymmetry evolved from a polysymmetric ancestor repeatedly in different angiosperm lineages, where it likely facilitated diversification through the interaction with insects. Most monosymmetric taxa are thus dominated by monosymmetric members. However, in the Brassicaceae, only few members develop a monosymmetric corolla with two petal pairs of unequal size, making them an ideal system to study the evolution of molecular mechanisms enhancing flower complexity. Monosymmetry is controlled by the TCP transcription factors that belong to the CYC2 clade in distantly related taxa. In Iberis amara, the first crucifer analyzed in terms of monosymmetry development, unequal corolla formation is due to a stronger CYC2 clade gene expression in the smaller adaxial petals compared with the larger abaxial ones. Phylogenetic reconstruction of the crucifer family reveals that the monosymmetric genera Iberis, Calepina, and Teesdalia belong to one major crucifer lineage. Monosymmetry is most pronounced in Iberis and less so in Calepina and Teesdalia, with a positive dosage-dependent correlation between the strength of a CYC2 expression difference and the extent of monosymmetry formation. An early adaxial CYC2 expression in floral meristems, observed in many distantly related taxa, might have facilitated the repeated evolution of CYC2-controlled monosymmetry. Comparison of early and late CYC2 expression in monosymmetric and polysymmetric crucifers representative for the four major crucifer lineages reveals that an adaxial CYC2 expression in floral meristems is likely ancestral for the Brassicaceae. However, it got lost in all analyzed monosymmetric members and is, as such, not a prerequisite for the establishment of corolla monosymmetry in crucifers. Here, monosymmetry evolved via a heterochronic CYC2 expression shift from an ancestral early adaxial expression in floral meristems to an adaxial CYC2 transcript accumulation later in petal development. This study emphasizes the potential of regulatory changes in the evolution of morphological novelties, like corolla monosymmetry in the Brassicaceae. In combination with a corymboid inflorescence, monosymmetry might have served as a key invention driving diversification in the genus Iberis comprising more than 20 monosymmetric species.