Autosomal recessive SLC30A9 variants in a proband with a cerebrorenal syndrome and no parental consanguinity.

An SLC30A9-associated cerebrorenal syndrome was first reported in consanguineous Bedouin kindred by Perez et al. in 2017. Although the function of the gene has not yet been fully elucidated, it may be implicated in Wnt signaling and nuclear regulation, as well as in cell and mitochondrial zinc regulation. In this research report, we present a female proband with two distinct, inherited autosomal recessive loss-of-function SLC30A9 variants from unrelated parents. To our knowledge, this is the first reported case of a possible SLC30A9-associated cerebrorenal syndrome in a nonconsanguineous family. Furthermore, a limited statistical analysis was conducted to identify possible allele frequency differences between populations. Our findings provide further support for an SLC30A9-associated cerebrorenal syndrome and may help clarify the gene's function through its possible disease association.

Life cycle assessment of bottled water: A case study of Green2O products.

This study conducted a full life cycle analysis of bottled water on four types of bottles: ENSO, PLA (corn based), recycled PET, and regular (petroleum based) PET, to discern which bottle material is more beneficial to use in terms of environmental impacts. PET bottles are the conventional bottles used that are not biodegradable and accumulate in landfills. PLA corn based bottles are derived from an organic substance and are degradable under certain environmental conditions. Recycled PET bottles are purified PET bottles that were disposed of and are used in a closed loop system. An ENSO bottle contains a special additive which is designed to help the plastic bottle degrade after disposed of in a landfill. The results showed that of all fourteen impact categories examined, the recycled PET and ENSO bottles were generally better than the PLA and regular PET bottles; however, the ENSO had the highest impacts in the categories of global warming and respiratory organics, and the recycled PET had the highest impact in the eutrophication category. The life cycle stages that were found to have the highest environmental impacts were the bottle manufacturing stage and the bottled water distribution to storage stage. Analysis of the mixed bottle material based on recycled PET resin and regular PET resin was discussed as well, in which key impact categories were identified. The PLA bottle contained extremely low impacts in the carcinogens, respiratory organics and global warming categories, yet it still contained the highest impacts in seven of the fourteen categories. Overall, the results demonstrate that the usage of more sustainable bottles, such as biodegradable ENSO bottles and recycled PET bottles, appears to be a viable option for decreasing impacts of the bottled water industry on the environment.

Environmental and economic analysis of an in-vessel food waste composting system at Kean University in the U.S.

A composting system provides many benefits towards achieving sustainability such as, replacing fertilizer use, increasing the quantity of produce sold, and diverting organic wastes from landfills. This study delves into the many benefits a composting system provided by utilizing an established composting system at Kean University (KU) in New Jersey, as a scale project to examine the composters' environmental and economic impacts. The results from the study showed that composting food wastes in an in-vessel composter when compared to typical disposal means by landfilling, had lower impacts in the categories of fossil fuel, GHG emissions, eutrophication, smog formation and respiratory effects; whereas, its had higher impacts in ozone depletion, acidification human health impacts, and ecotoxicity. The environmental impacts were mainly raised from the manufacturing of the composter and the electricity use for operation. Applying compost to the garden can replace fertilizers and also lock carbon and nutrients in soil, which reduced all of the environmental impact categories examined. In particular, the plant growth and use stage reduced up to 80% of respiratory effects in the life cycle of food waste composting. A cost-benefit analysis showed that the composting system could generate a profit of $13,200 a year by selling vegetables grown with compost to the student cafeteria at Kean and to local communities. When educational and environmental benefits were included in the analysis, the revenue increased to $23,550. The results suggest that in-vessel composting and the subsequent usage of a vegetable garden should be utilized by Universities or food markets that generate intensive food wastes across the U.S.