Eigenpulses of Dispersive Time-Varying Media.

We develop a compact theory that can be applied to a variety of time-varying dispersive materials. The continuous-wave reflection and transmission coefficients are replaced with equivalent operator expressions. In addition to comparing this approach to existing numerical and analytical techniques, we find that the eigenfunctions of these operators represent pulses that do not change their spectra after interaction with the time-varying, dispersive material. In addition, the poles of these operators represent the nontime harmonic bound states of the system.

Microwave demonstration of Purcell effect enhanced radiation efficiency.

We experimentally demonstrate a Purcell effect-based design technique for improved impedance matching, and thus enhanced the reflection coefficient from a small microwave emitter. Using an iterative process centred on comparing the phase of the radiated field of the emitter in air with that of the emitter in a dielectric environment, we optimise the structure of a dielectric hemisphere above a ground plane surrounding a small monopolar microwave emitter in order to maximise its radiation efficiency. The optimised system shows very strong coupling between the emitter and two omnidirectional radiation modes at 1.99 GHz and 2.84 GHz, yielding Purcell enhancement factors of 1762 and 411 times increase respectively, and near perfect radiation efficiency.

Initial impact of the COVID-19 pandemic on public health training: participatory action research to understand experiences in the East Midlands.

BACKGROUND: Specialty public health training consists of 48 months of practice across the domains of health protection, healthcare public health and health improvement.With the onset of the COVID-19 pandemic, activity pivoted towards pandemic management and the response became a significant element of registrar practice.This research aimed to understand the impact of this shift in focus on registrars' role and training. METHODS: Participatory action research comprising (i) a reflective survey sent to all specialty registrars in the East Midlands training region and (ii) Delphi rounds with survey respondents to generate consensus and define themes. RESULTS: Sixteen (44%) registrars completed the survey with 12 (75%) participating in the Delphi rounds. The early pandemic response stages both challenged and re-affirmed registrars' role and identity in public health and training while providing unique and diverse learning and development. Underpinning these themes is a variability in experience depending on prior experience, placement and training stage. CONCLUSIONS: The pandemic impacted the practice, training and home-life of registrars who were required to negotiate significant challenge and uncertainty. This original work adds to a growing body of correspondence and opinion pieces articulating the experiences and challenges of medical and public health education during a pandemic.

Evaluating an 'incident control' approach to non-communicable disease.

OBJECTIVES: This article evaluates the application of 'incident control' methodology usually applied in communicable disease control to an 'incident' of unexplained deaths, specifically to resolve a significant difference in 1-year survival after a lung cancer diagnosis observed between two Clinical Commissioning Groups and the England national average, 2011-14. The purpose of the evaluation was to assess whether a formalised incident control approach is feasible and effective in improving outcomes for non-communicable diseases. STUDY DESIGN: Descriptive, qualitative, process evaluation. METHODS: There were two components to the evaluation: a document review against identified phases of a non-communicable disease incident control framework and a qualitative analysis of semi-structured interviews with stakeholders who had been involved in implementation. RESULTS: The findings indicate feasibility of the incident control model, with some limitations. Identified strengths of the model included the articulation of a clear case and incident definition. The structure and stepped phased approach facilitated partner engagement, robust data analysis, action planning and communication strategies. Delays in data publication and the lack of comparable data across different non-communicable diseases present challenges in timely response and prioritisation of 'incidents'. CONCLUSIONS: The evaluation indicates value in applying defined incident control methodology to management of non-communicable diseases, especially where there is identification of a potential outlier or a measurable variation, i.e. there is a definable 'incident' and 'case'.

Calculating coherent light-wave propagation in large heterogeneous media.

Understanding the interaction of light with a highly scattering material is essential for optical microscopy of optically thick and heterogeneous biological tissues. Ensemble-averaged analytic solutions cannot provide more than general predictions for relatively simple cases. Yet, biological tissues contain chiral organic molecules and many of the cells' structures are birefringent, a property exploited by polarization microscopy for label-free imaging. Solving Maxwell's equations in such materials is a notoriously hard problem. Here we present an efficient method to determine the propagation of electro-magnetic waves in arbitrary anisotropic materials. We demonstrate how the algorithm enables large scale calculations of the scattered light field in complex birefringent materials, chiral media, and even materials with a negative refractive index.

Origins of All-Optical Generation of Plasmons in Graphene.

Graphene, despite its centrosymmetric structure, is predicted to have a substantial second order nonlinearity, arising from non-local effects. However, there is disagreement between several published theories and experimental data. Here we derive an expression for the second order conductivity of graphene in the non-local regime using perturbation theory, concentrating on the difference frequency mixing process, and compare our results with those already published. We find a second-order conductivity (σ(2) ≈ 10-17 AmV-2) that is approximately three orders of magnitude less than that estimated from recent experimental results. This indicates that nonlinear optical coupling to plasmons in graphene cannot be described perturbatively through the electronic nonlinearity, as previously thought. We also show that this discrepancy cannot be attributed to the bulk optical nonlinearity of the substrate. As a possible alternative, we present a simple theoretical model of how a non-linearity can arise from photothermal effects, which generates a field at least two orders of magnitude larger than that found from perturbation theory.

Perfect Transmission through Disordered Media.

The transmission of a wave through a randomly chosen "pile of plates" typically decreases exponentially with the number of plates, a phenomenon closely related to Anderson localization. In apparent contradiction, we construct disordered planar permittivity profiles which are complex valued (i.e., have reactive and dissipative properties) that appear to vary randomly with position, yet are one-way reflectionless for all angles of incidence and exhibit a transmission coefficient of unity. In addition to these complex-valued "random" planar permittivity profiles, we construct a family of real-valued, two-way reflectionless and perfectly transmitting disordered permittivity profiles that function only for a single angle of incidence and a narrow frequency range.

Direct observation of negative-index microwave surface waves.

Waves propagating in a negative-index material have wave-front propagation (wavevector, k) opposite in direction to that of energy flow (Poynting vector, S). Here we present an experimental realisation at microwave frequencies of an analogous surface wave phenomenon whereby a metasurface supports a surface mode that has two possible wavevector eigenstates within a narrow band of frequencies: one that supports surface waves with positive mode index, and another that supports surface waves with negative mode index. Phase sensitive measurements of the near-field of surface waves across the metasurface show the contrasting spatial evolution of the two eigenstates, providing a unique opportunity to directly observe the negative-index phenomenon.

Illusions and cloaks for surface waves.

Ever since the inception of Transformation Optics (TO), new and exciting ideas have been proposed in the field of electromagnetics and the theory has been modified to work in such fields as acoustics and thermodynamics. The most well-known application of this theory is to cloaking, but another equally intriguing application of TO is the idea of an illusion device. Here, we propose a general method to transform electromagnetic waves between two arbitrary surfaces. This allows a flat surface to reproduce the scattering behaviour of a curved surface and vice versa, thereby giving rise to perfect optical illusion and cloaking devices, respectively. The performance of the proposed devices is simulated using thin effective media with engineered material properties. The scattering of the curved surface is shown to be reproduced by its flat analogue (for illusions) and vice versa for cloaks.

Lenses on curved surfaces.

This Letter presents a theory that allows graded index lenses to be mapped onto arbitrary rotationally symmetric curved surfaces. Examples of the Luneburg and Maxwell fish-eye lens are given, for numerous surfaces, always resulting in isotropic permittivity requirements. The performance of these lenses is initially illustrated with full-wave simulations utilizing a waveguide structure. A transformation of the refractive index profiles is then performed to design surface-wave lenses, where the dielectric layer is not only isotropic but also homogenous, demonstrating the applicability and ease of fabrication.

Removing singular refractive indices with sculpted surfaces.

The advent of Transformation Optics established the link between geometry and material properties, and has resulted in a degree of control over electromagnetic fields that was previously impossible. For waves confined to a surface it is known that there is a simpler, but related, geometrical equivalence between the surface shape and the refractive index, and here we demonstrate that conventional devices possessing a singularity - that is, the requirement of an infinite refractive index - can be realised for waves confined to an appropriately sculpted surface. In particular, we redesign three singular omnidirectional devices: the Eaton lens, the generalized Maxwell Fish-Eye, and the invisible sphere. Our designs perfectly reproduce the behaviour of these singular devices, and can be achieved with simple isotropic media of low refractive index contrast.

Perfect surface wave cloaks.

This Letter presents a method for making an uneven surface behave as a flat surface. This allows an object to be concealed (cloaked) under an uneven portion of the surface, without disturbing the wave propagation on the surface. The cloaks proposed in this Letter achieve perfect cloaking that only relies upon isotropic radially dependent refractive index profiles, contrary to those previously published. In addition, these cloaks are very thin, just a fraction of a wavelength in thickness, yet can conceal electrically large objects. While this paper focuses on cloaking electromagnetic surface waves, the theory is also valid for other types of surface waves. The performance of these cloaks is simulated using dielectric filled waveguide geometries, and the curvature of the surface is shown to be rendered invisible, hiding any object positioned underneath. Finally, a transformation of the required dielectric slab permittivity was performed for surface wave propagation, demonstrating the practical applicability of this technique.

Optical nonreciprocity of cold atom Bragg mirrors in motion.

Reciprocity is fundamental to light transport and is a concept that holds also in rather complex systems. Yet, reciprocity can be switched off even in linear, isotropic, and passive media by setting the material structure into motion. In highly dispersive multilayers this leads to a fairly large forward-backward asymmetry in the pulse transmission. Moreover, in multilevel systems, this transport phenomenon can be all-optically enhanced. For atomic multilayer structures made of three-level cold 87Rb atoms, for instance, forward-backward transmission contrast around 95% can be obtained already at atomic speeds in the meter per second range. The scheme we illustrate may open up avenues for optical isolation that were not previously accessible.

Radiation damping in atomic photonic crystals.

The force exerted on a material by an incident beam of light is dependent upon the material's velocity in the laboratory frame of reference. This velocity dependence is known to be difficult to measure, as it is proportional to the incident optical power multiplied by the ratio of the material velocity to the speed of light. Here we show that this typically tiny effect is greatly amplified in multilayer systems composed of resonantly absorbing atoms exhibiting ultranarrow photonic band gaps. The amplification effect for optically trapped 87Rb is shown to be as much as 3 orders of magnitude greater than for conventional photonic-band-gap materials. For a specific pulsed regime, damping remains observable without destroying the system and significant for material velocities of a few ms(-1).

Evidence-based commissioning: using population impact measures to help primary care trusts estimate the benefit of interventions in diabetes and heart failure.

OBJECTIVE: To test the feasibility of applying population impact measures utilising local population data on established interventions for heart failure and diabetes mellitus. DESIGN: Modelling study. Setting Registered general practitioner (GP) population in a primary care trust (PCT) Data sources Local data sources included the quality and outcomes framework, chronic disease registers for coronary heart disease and diabetes, hospital episode statistics and a range of published risk data in heart failure and diabetes. MAIN OUTCOME MEASURES: Number of events prevented in the population (NEPP) by increasing the uptake of established interventions expressed as the number of deaths, hospitalisations and cardiovascular events prevented. RESULTS: Data from 17 GP practices (representing 55% of the PCT GP registered population) were used to derive the NEPP. A 10% increase in the number of eligible patients receiving ACE inhibitors (n = 191) could result in at least 18 fewer deaths (95% CI 9.8 to 27.1) and 32 fewer hospitalisations (95% CI 24.9 to 40.7) for heart failure every year. Only 45% of persons with diabetes with an above target total cholesterol were receiving a statin; increasing this to 75% (additional 921) could lead to 44 (95% CI 15.6 to 73.1) fewer cardiovascular disease (CVD) events over 5 years. Similarly, more rigorous blood pressure control in an additional 662 diabetic patients could result in 26 (95% CI -2.7 to 55.6) fewer CVD events over 5 years. There were differences in the potential impact of these interventions according to subgroups within the PCT, as defined by age and geography (locality). CONCLUSIONS: Local data and published literature estimates can be successfully combined to produce the number of events prevented within a locally defined PCT population (NEPP). Commissioners have shown interest in the utility of such a measure in identifying and quantifying areas for improvement.

Topological phases for composite particles with dynamic properties.

We show that, if a given electromagnetic property of a particle is allowed to vary during an evolution where the particle will accrue a topological phase, then it is both the time average and the statistical variance of this property which will affect the observable phenomena. The time average is shown to affect the topological aspect of the phase. This is in addition to a second smaller dynamical phase term, which depends upon only the variance of the changing property. The theory is illustrated in reference to the time dependence of the dipole moment in both the Aharonov-Casher and He-McKellar-Wilkens effects.

Translocation between chromosome 5q35 and chromosome 11q13-- an unusual cytogenetic finding in a primary refractory acute myeloid leukemia.

Cytogenetic abnormalities are observed in approximately two-thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B-cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case.

Röntgen quantum phase shift: a semiclassical local electrodynamical effect?

The Röntgen quantum phase shift is exhibited by the interference of point particles endowed with an electric dipole moment due to their motion relative to a source of the magnetic field. Here we show, using arguments involving the classical concepts of force and its impulse, that the Röntgen phase shift arises within a largely classical (semiclassical) theoretical framework. All the subtleties normally associated with the nonlocality of magnetic (Aharonov-Bohm-type) quantum phase phenomena are uncontroversially absent in the classical treatment.