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1.
Braz J Med Biol Res ; 41(10): 932-7, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19030714

RESUMO

We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 +/- 14) with disease from 0.4 to 23 years (6.7 +/- 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 +/- 2.0). RLS was detected in 12 cases (27%). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). Fatigue was present in 32 subjects (73%) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.


Assuntos
Distúrbios do Sono por Sonolência Excessiva/etiologia , Fadiga/etiologia , Esclerose Múltipla/complicações , Síndrome das Pernas Inquietas/complicações , Adolescente , Adulto , Estudos Transversais , Distúrbios do Sono por Sonolência Excessiva/diagnóstico , Fadiga/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome das Pernas Inquietas/diagnóstico , Índice de Gravidade de Doença , Adulto Jovem
2.
Braz. j. med. biol. res ; 41(10): 932-937, Oct. 2008. ilus, tab
Artigo em Inglês | LILACS | ID: lil-496806

RESUMO

We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 ± 2.0). RLS was detected in 12 cases (27 percent). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52 percent) and excessive daytime sleepiness in 3 cases (6.8 percent). Fatigue was present in 32 subjects (73 percent) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Distúrbios do Sono por Sonolência Excessiva/etiologia , Fadiga/etiologia , Esclerose Múltipla/complicações , Síndrome das Pernas Inquietas/complicações , Estudos Transversais , Distúrbios do Sono por Sonolência Excessiva/diagnóstico , Fadiga/diagnóstico , Síndrome das Pernas Inquietas/diagnóstico , Índice de Gravidade de Doença , Adulto Jovem
3.
Arq Neuropsiquiatr ; 58(4): 986-9, 2000 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11105062

RESUMO

In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.


Assuntos
Doença dos Neurônios Motores/diagnóstico , Adolescente , Adulto , Distribuição por Idade , Idoso , Esclerose Lateral Amiotrófica/diagnóstico , Brasil , Paralisia Bulbar Progressiva/diagnóstico , Diagnóstico Diferencial , Feminino , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Atrofia Muscular Espinal/diagnóstico , Estudos Retrospectivos , Fatores de Risco
4.
Arq Neuropsiquiatr ; 58(3B): 916-8, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11018833

RESUMO

We report on the preliminary clinical and electrophysiological aspects of an in-patient possibly presenting epilepsia partialis continua (Koshevnikov). We discuss the different etiologies and emphasize on the possible idiopathic form in this case.


Assuntos
Epilepsia Parcial Contínua/diagnóstico , Adulto , Epilepsia Parcial Contínua/etiologia , Epilepsia Parcial Contínua/fisiopatologia , Feminino , Humanos
5.
Am J Trop Med Hyg ; 58(6): 759-62, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9660459

RESUMO

Relatively little is known about the occurrence of neurocysticercosis in northeastern Brazil. There have been no published reports from the state of Ceará, but a review of the records at the Hospital São José in Fortaleza, Brazil identified 119 patients with neurocysticercosis diagnosed between January 1988 and April 1994. Patients came from 43 municipalities in Ceará. Their ages ranged from five to 74 years; the greatest number of cases were in persons 10-40 years of age; 63% were males. Seizures were the presenting complaint in 64% of the patients and headache in 22%. Two patients, each with several hundred intracranial lesions, presented with mental status changes; one was initially given the clinical diagnosis of viral meningoencephalitis. Computed tomography scans showed that 44% of the patients had five or more lesions. Cysts were found throughout the brain. The parietal lobe was the most frequent site of involvement; 85% of patients had one or more lesions there. The brain stem was involved in 8%. There was no consistent association between the severity of the clinical abnormalities and the radiologic findings. Computed tomography of the thighs was done in 10 persons; cysts were identified in nine.


Assuntos
Encefalopatias/epidemiologia , Cisticercose/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Encéfalo/diagnóstico por imagem , Encéfalo/parasitologia , Encefalopatias/diagnóstico , Brasil/epidemiologia , Criança , Pré-Escolar , Cisticercose/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Morbidade , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/parasitologia , Estudos Retrospectivos , Distribuição por Sexo , Coxa da Perna , Tomografia Computadorizada por Raios X
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