RESUMO
BACKGROUND: Both high-sensitivity C-reactive protein (hs- CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. METHODS AND RESULTS: We studied the association between hs- CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008). CONCLUSION: High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.
Assuntos
Calcinose/metabolismo , Cálcio/metabolismo , Doença da Artéria Coronariana/metabolismo , Vasos Coronários/metabolismo , Receptores alfa dos Hormônios Tireóideos/metabolismo , Idoso , Calcinose/diagnóstico por imagem , Angiografia Coronária , Doença da Artéria Coronariana/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Nefelometria e Turbidimetria , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Tomografia Computadorizada por Raios XRESUMO
Background : Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. Methods and results : We studied the association between hs-CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study; we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However; in patients who did not use statins; this association was significant and positive in the bivariant analysis (p = 0.001); but in the multivariant analysis it was negative and significant (p = 0.008). Conclusion : High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation; such as hs-CRP; and indices of atherosclerosis; such as CCS; are likely to provide distinct information regarding cardiovascular risk
