RESUMO
Pretibial myxedema, exophthalmus, and thyroid acropachy are the classic manifestations of Graves' Disease. However, myxedema in Graves' Disease can occur in locations other than the pretibial surfaces. Furthermore, with systemic symptoms, localized myxedema may occur at sites of trauma or scarring. We describe a patient with localized myxedema on the thigh at the site of a donor skin graft as the initial presentation of Graves' Disease.
Assuntos
Doença de Graves/complicações , Dermatoses da Perna/etiologia , Mixedema/etiologia , Coxa da Perna/patologia , Amputação Cirúrgica , Seguimentos , Humanos , Úlcera da Perna/etiologia , Úlcera da Perna/cirurgia , Masculino , Pessoa de Meia-Idade , Transplante de Pele/métodos , Insuficiência Venosa/complicaçõesRESUMO
Lymphomatoid contact dermatitis is a rarely reported entity consisting of allergic contact dermatitis that resembles mycosis fungoides pathologically. Although the histopathology has been previously described, there have been no attempts to reproduce the dermatitis for pathologic evaluation. A 68-year-old woman presented with a papular rash on her neck after exposure to a nickel-containing necklace. A biopsy specimen was suspicious for mycosis fungoides. However, the dermatitis responded quickly to topical steroids and avoidance of the necklace. A patch test to nickel was positive, and a biopsy specimen from the patch test site had no findings of mycosis fungoides. Although we were able to reproduce the contact dermatitis at a distant site, the disease was dissimilar. Lymphomatoid contact dermatitis has an excellent prognosis and resolves completely simply by avoiding the offending agent.
Assuntos
Alérgenos/efeitos adversos , Ligas/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Níquel/efeitos adversos , Administração Tópica , Idoso , Anti-Inflamatórios/uso terapêutico , Biópsia , Dermatite Alérgica de Contato/patologia , Diagnóstico Diferencial , Exantema/induzido quimicamente , Feminino , Glucocorticoides , Humanos , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Triancinolona/uso terapêuticoRESUMO
Tinea capitis has a wide variety of clinical presentations in adolescents and adults. However, the occurrence of fingerlike projections in the scalp has not been previously described. A 14-year-old girl presented with a one-year history of a painful scalp mass. Debridement of this mass revealed slender papillomatous growths resembling those seen in elephantiasis nostras verrucosa. A fungal culture grew Trichophyton mentagrophytes. We describe the first case of this unusual clinical variant of tinea capitis and hypothesize on its pathophysiological basis.
Assuntos
Tinha do Couro Cabeludo/patologia , Tinha do Couro Cabeludo/terapia , Trichophyton/isolamento & purificação , Adolescente , Adulto , Terapia Combinada , Desbridamento/métodos , Diagnóstico Diferencial , Feminino , Griseofulvina/administração & dosagem , Griseofulvina/uso terapêutico , Humanos , Tinha do Couro Cabeludo/diagnóstico , Tinha do Couro Cabeludo/fisiopatologiaRESUMO
Sea nettle (Chrysaora quinquecirrha) venom (CQV) is known to be toxic to the cardiac, respiratory, renal and hepatic systems in animal models. However, the mechanism of toxicity of CQV on hepatocytes is unknown. We utilized isolated rat hepatocytes in culture and measured percentage total lactate dehydrogenase (LDH) release after direct exposure to CQV. Toxicity of CQV in this system produced a linear multiple-dose response curve as well as a linear single-dose kinetics curve. Neither extracellular calcium concentration nor intracellular calcium chelation had a statistically significant effect on the toxicity of CQV in our hepatocyte model. From these results it appears that CQV does not form large membrane channels similar to complement, nor does calcium appear to play a major role in the mechanism of toxicity in hepatocytes. The isolated rat hepatocyye culture and measure of LDH release provided a relatively simple and reproducible model for examining toxicity of CQV.
