RESUMO
OBJECTIVE: To describe 2 enucleated eyes of patients enrolled in the Collaborative Ocular Melanoma Study that contained primary choroidal melanoma with clear cell features. METHODS: During a 9-year period, 1493 eyes enucleated as part of the Collaborative Ocular Melanoma Study routinely processed for histologic examination were evaluated by the pathology review committee (H.E.G, D.M.A, and W.R.G). Two eyes with unusual variants of choroidal melanoma were identified and immunostained for S100 protein and HMB 45. Portions of the tumors were processed for electron microscopic examination. RESULTS: Results of electron microscopic examination of both tumors displayed malignant melanoma (mixed cell type with many malignant cells with clear cytoplasm). The cytoplasm of the clear cells stained with periodic acid-Schiff and failed to stain when pretreated with diastase. Results of immunohistochemical stains in both tumors were positive for S100 protein and HMB 45 in the tumor cells. Results of electron microscopic examination showed that the cytoplasm of the clear cells contained scattered glycogen granules, premelanosomes, and melanosomes. CONCLUSION: These cases represent a clear cell variant of malignant melanoma of the choroid. This tumor should not be confused with metastatic clear cell carcinoma to the choroid.
Assuntos
Neoplasias da Coroide/patologia , Melanoma/patologia , Idoso , Antígenos de Neoplasias/análise , Biomarcadores Tumorais/análise , Biópsia , Divisão Celular , Neoplasias da Coroide/química , Neoplasias da Coroide/cirurgia , Diagnóstico Diferencial , Enucleação Ocular , Evolução Fatal , Seguimentos , Humanos , Imuno-Histoquímica , Masculino , Melanoma/química , Melanoma/cirurgia , Antígenos Específicos de Melanoma , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Recidiva Local de Neoplasia , Proteínas S100/análiseRESUMO
Two unrelated patients with thoracic-pelvic-phalangeal dystrophy syndrome had retinal degeneration. A pathologic study of both eyes from one of the patients showed severe degeneration of the peripheral retina, with predominantly cone-type cells remaining.
Assuntos
Anormalidades Múltiplas , Osso e Ossos/anormalidades , Degeneração Retiniana/complicações , Tórax/anormalidades , Anormalidades Múltiplas/diagnóstico , Criança , Pré-Escolar , Feminino , Dedos/anormalidades , Angiofluoresceinografia , Humanos , Lactente , Recém-Nascido , Masculino , Ossos Pélvicos/anormalidades , Degeneração Retiniana/diagnóstico , Degeneração Retiniana/patologia , Estrabismo/complicações , Síndrome , Dedos do Pé/anormalidadesRESUMO
One hundred patients had bilateral aphakia, primary rhegmatogenous retinal detachment, and adequate visualization of the retinal and vitreous in the fellow eye. Of 43 patients with posterior vitreous separation and no retinal tear in the fellow eye, only one (2%) subsequently developed retinal detachment. Of 40 patients without posterior vitreous separation in the fellow eye, eight (20%) later developed retinal detachment following posterior vitreous separation. The remaining 17 patients had posterior vitreous separation and retinal tear or detachment at the time of initial examination. Thus, if posterior vitreous separation occurs without forming retinal tear, the risk of developing retinal detachment is significantly lowered.
