[Renoprotective effect of monopril in patients with diabetes mellitus in the preclinical stage of diabetic nephropathy]. / Renoprotektornyi efekt monoprylu u khvorykh na tsukrovyi diabet v doklinichnii stadiï diabetychnoï nefropatiï.

As many as 15 patients with insulin-dependent diabetes mellitus received monopril in a dose of 5 mg daily. Studied in the patients was the drug effect on the functional renal reserve and glomerular filtration rate. Determination of the functional renal reserve has been shown to be a criterion for an early diagnosis of the preclinical stage of diabetic nephropathy. Administration of monopril in exhausted functional renal reserve permits preventing development of proteinuria or allows a lapse of time for it to develop.

[Therapeutic efficacy of lacidipine in patients with chronic glomerulonephritis and diabetic nephropathy]. / Efektyvnist' latsydypinu v likuvanni khvorykh na khronichnyi hlomerulonefryt ta diabetychnu nefropatiiu.

A total of 30 patients with diabetic nephropathy were examined together with 30 patients presenting with chronic glomerulonephritis at different stages of the condition. An unquestionable positive effect has been demonstrated of lacidipine on the arterial pressure, glomerular filtration rate, proteinuria, diuresis, excretion of nitrogenous metabolities in patients with the above pathology presenting with the normal or impaired renal function. A prognostic criterion has been developed for efficiency of treatment with lacidipine making use of the corinfar test.