[Lovastatin in the treatment of hypercholesterolemia]. / Lowastatyna w leczeniu hipercholesterolemii.

In 9 clinics 177 patients (68 men and 109 women) aged 23-69 years with primary hypercholesterolemia (TC above 6.5 mmol/L) were treated with lovastatin for 12 weeks. The treatment was started with 20 mg daily. The dose was doubled every 4 weeks, if the total serum cholesterol level did not fall below 5.2 mmol/L. For 4 weeks before treatment with lovastatin all patients received placebo. After the first 4 weeks of therapy the mean TC level decreased significantly (from 8.09 mmol/L to 6.54 mmol/L) by 18.5%. In comparison with the results after placebo (the starting value), after the 8 weeks of the therapy the TC level reduction reached 22.4% and after 12 weeks 23.5%. The mean LDL cholesterol decreased by 26.1%, 30.8% and 32.9% after 4.8 and 12 weeks of lovastatin treatment respectively. An increase in HDL cholesterol by 5.9%, 6.0% and 7.6% and decrease in triglyceride level by 10.7%, 14.9% and 14.0% respectively was also observed. In 6 patients on lovastatin treatment symptoms of acute pancreatitis in 1 case, a cataract in 1 case and aggravation of coronary insufficiency in 4 cases were noticed. These symptoms in the light of our knowledge of the mechanism of action of the drug used and of its side effects described in other trials, may be considered of independent on lovastatin. The treatment was discontinued in 5 cases (because of gastrointestinal intolerance in 2 patients, of aggravation of coronary insufficiency in 2 patients and of pain in the right hypochondrium in 1 patient who himself decided to stop the therapy).(ABSTRACT TRUNCATED AT 250 WORDS)

[Effect of compositional modification of coffee on certain indices of lipid metabolism in healthy volunteers and patients with hyperlipoproteinemia]. / Wplyw modyfikacji skladu kawy na niektóre wskazniki gospodarki lipidowej u osób zdrowych i chorych na hiperlipoproteinemie.

An effect of a 14-day drinking of coffee on some blood serum indices of lipid metabolism was investigated in 20 healthy volunteers and 20 patients with hyper lipoproteinemia (type IIb). The study was carried out in two subgroups: healthy volunteers or patients with hyperlipoproteinemia assigned to the first subgroup drank ordinary coffee and patients assigned to the second subgroup drank coffee deprived of irritant substances (4 glasses daily). It was found that ordinary coffee significantly increased total serum cholesterol and decreased serum HDL-cholesterol in healthy volunteers. Such effects were not seen in subgroup drinking coffee deprived of irritant substances. More significant increase in serum total cholesterol and decrease in serum HDL-cholesterol were found in patients with hyperlipoproteinemia. Drinking of modified coffee does not cause any significant changes in serum lipid metabolism. The authors concluded that drinking of the ordinary coffee should be restricted in patients with hyperlipoproteinemia and use of coffee deprived of irritant substances might be recommended to patients with this disease.

The effect of coffee deprived of irritant substances upon some indices of lipid metabolism in healthy volunteers and patients with hyperlipoproteinemia.

Effect of 14 days coffee drinking upon some blood serum indices of lipid metabolism was studied on 20 healthy volunteers and 20 patients with hyperlipoproteinemia (type IIb). The study was done in two subgroups: healthy volunteers or patients with hyperlipoproteinemia which had belonged to the first subgroup drank ordinary coffee and the ones which belonged to the second subgroup drank coffee deprived of irritant substances. (4 glasses per day). It was found that in healthy volunteers ordinary coffee had given rise to a significant increase of serum total cholesterol and to a decrease of serum HDL-cholesterol. These changes were not observed in subgroup drinking coffee deprived of irritant substances. More significant rise of serum total cholesterol and decrease of serum HDL-cholesterol were found in patients with hyperlipoproteinemia. Drinking of modified coffee does not cause any significant changes in serum indices of lipid metabolism. The authors concluded that drinking of ordinary coffee should be restricted in patients with hyperlipoproteinemia and coffee deprived of irritant substances might be recommended to patients with this disease.

Nutrition and development of gastric cancer.

Gastric cancerogenesis is a multistage process. Dietary studies may contribute to elucidation of that complex problem.

[Clinical and metabolic evaluation of patients with chronic pancreatitis following a special peptide diet]. / Die klinische und metabolische Beurteilung der chronisch Pankreatitiskranken nach besonderer Peptiddiät.

The purpose of present investigations was to evaluate the effect of peptide diet upon clinical and metabolic course of chronic pancreatitis. Nitrogen, potassium and sodium balances were done for 24 days in 4 patients with chronic pancreatitis fed with peptide diet as well as in 5 patients fed with normal low fat diet. Administration of peptide diet improved protein nutritional status of all patients, due to better absorption of aminoacid components and increased nitrogen retention. On the basis of obtained results the authors discuss possibility of dietary treatment of chronic pancreatitis with peptide diet.

[Double-blind study on therapy with new drugs in stomach and duodenal ulcers]. / Doppelblindstudie zur Therapie mit neuen Pharmaka bei Magen- und Zwölffingerdarmgeschwüren.

Patients with ulcers of the stomach and the duodenum were treated with Pirenzepin and the new H2-inhibitor Renitidin. The effects were evaluated on the basis of a double blind trial. After the endoscopic diagnosis repeated examinations were practiced until three weeks after the beginning of the treatment. The best results were found in duodenal ulcers after treatment with Renitidin. 86,6% of the ulcers were healed after 3 weeks of treatment. This results was statistically significant compared with a group of patients treated with a placebo. With gastrozepin 77,2% of patients were successfully treated. In ulcers of the stomach the results were not so good and statistically insignificant. Side effects were not found. Until now it is not possible to decide which substance guarantees better results.