RESUMO
A micro-controller unit (MCU) assisted immunoassay lab-on-a-chip is realized in 0.35 µm CMOS technology. The MCU automatically controls the detection procedure including blood filtration through a nonporous aluminum oxide membrane, bimolecular conjugation with antibodies attached to magnetic beads, electrolytic pumping, magnetic flushing and threshold detection based on Hall sensor array readout analysis. To verify the function of this chip, in-vitro Tumor necrosis factor- α (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP) tests are performed by this 9 mm(2)-sized single chip. The cost, efficiency and portability are considerably improved compared to the prior art.
Assuntos
Análise Química do Sangue/instrumentação , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Fator de Necrose Tumoral alfa/sangue , Humanos , Imunoensaio , Dispositivos Lab-On-A-Chip/economia , Sistemas Automatizados de Assistência Junto ao LeitoRESUMO
A batteryless remotely-controlled locomotive IC utilizing electrolytic bubbles as propelling force is realized in 0.35 µm CMOS technology. Without any external components, such as magnets and on-board coils, the bare IC is wirelessly powered and controlled by a 10 MHz ASK modulated signal with RS232 control commands to execute movement in four moving directions and with two speeds. The receiving coil and electrolysis electrodes are all integrated on the locomotive chip. The experiment successfully demonstrated that the bare IC moved on the surface of an electrolyte with a speed up to 0.3 mm/s and change moving directions according to the commands. The total power consumptions of the chip are 207.4 µW and 180 µ W while the output electrolysis voltages are 2 V and 1.3 V, respectively.
