Downregulation of CRTAC1 in Urothelial Carcinoma Promotes Tumor Aggressiveness and Confers Poor Prognosis.

BACKGROUND: Cartilage acidic protein 1 (CRTAC1) is a glycosylated calcium-binding extracellular matrix protein. The oncological functions of CRTAC1 in urothelial carcinoma (UC) of the urinary bladder (UB) and upper urinary tract (UT) have not yet been elucidated. Based on the published UBUC transcriptome data, we re-evaluated the differential expression profile of calcium ion binding-related genes (GO:0005509), and we found that CRTAC1 was the most significantly downregulated gene in UBUC progression. Therefore, we analyzed the prognostic value and biological significance of CRTAC1 expression in UC. METHODS: We used immunohistochemistry to determine the CRTAC1 expression levels in 340 patients with UTUC and 295 patients with UBUC. The CRTAC1 expression was compared with the clinicopathological characteristics, and the prognostic impact of CRTAC1 on metastasis-free survival (MFS) and disease-specific survival (DSS) was evaluated. To study the biological functions of CRTAC1, the proliferation, migration, invasion, and tube formation abilities of UC-derived cells were evaluated. RESULTS: A low CRTAC1 expression significantly correlated with high tumor stage, high histological grade, perineural invasion, vascular invasion, nodal metastasis, and high mitotic rate (all p < 0.01). Moreover, the CRTAC1 immunoexpression status was an independent prognostic factor for MFS and DSS in UBUC and UTUC patients (all p < 0.001) in the multivariate analysis. The exogenous expression of CRTAC1 suppressed the cell proliferation, invasion, and angiogenesis, and downregulated the matrix metallopeptidase 2 (MMP2) level in BFTC909 and T24 cells. CONCLUSIONS: CRTAC1 may participate in progression of UC and serve as a prognostic marker for metastasis. Low CRTAC1 expression was significantly associated with aggressive UC characteristics and worse clinical outcomes. The inclusion of CRTAC1 immunoexpression in the standard pathological variables may optimize the risk stratification of patients.

Bipedal Static Supination and Dynamic Forefoot Loading Characteristics in Taiwanese College Badminton Players: A Cross-Sectional Study.

CONTEXT: Badminton is a unilateral sport that involves repetitive jumping, lunging and quick changes of direction with the lower limb, thus, plantar pressure profiles and foot postural profiles are critical to maintaining balance and coordination. OBJECTIVE: The purpose of this study was to explore the characteristics of static and dynamic plantar pressure profiles with rearfoot posture in elite and recreational badminton players as well as assess the transitional changes of plantar loads between static and dynamic states. METHODS: A cross-sectional survey was conducted among 65 college-level elite male badminton players (mean age: 20.2 ± 1.2 years; mean height: 177.4 ± 4.6 cm; mean weight: 72.6 ± 4.6 kg) and 68 recreational badminton players of the same gender (mean age: 19.9 ± 0.8 years; mean height: 170.3 ± 3.9 cm; mean weight: 67.7 ± 3.2 kg). The JC Mat was used to evaluate the arch index (AI), plantar pressure distribution (PPD), centers of gravity, and the characteristics of the footprint. Static foot posture was determined by examining the rearfoot alignment. RESULTS: Both groups' AI fell within the normal range. The static plantar loads of the elite group were distributed at the bipedal lateral part of longitudinal arches and heels (p < 0.01), while the right foot experienced higher centers of gravity (p < 0.05). The elite group's static rearfoot postural alignment exhibited a higher degree of rearfoot varus than the recreational group (p < 0.05). In addition, the elite group's dynamic plantar loads were mainly exerted at the medial and lateral metatarsals of both feet (p < 0.05). During the transition state, the recreational group's plantar loads were mainly shifted to the bipedal lateral part of metatarsals and heels (p < 0.05), whereas the elite group's bipedal lateral longitudinal arches as well as the medial and lateral heels experienced a reduction in plantar loads (p < 0.01). CONCLUSION: For elite badminton players, the findings revealed a possible connection among the static supinated foot, centers of gravity tending towards the right foot, and increased forefoot plantar loads in the dynamic state. The finding merits further exploration of the possible links between transitional changes in plantar pressure distribution in both states and related foot injuries resulting from intense competition and regular training in badminton.

Elite Tennis Players Experiencing High-Arched Supination and Cuboids Dropped Foot Syndromes in Daily Normal Gait.

Many studies have focused on the plantar pressure characteristics of specific movements and footwork in tennis. However, little research has been conducted for exploring the foot characteristics among tennis professionals' daily habitual paces. This study aims to examine the pressure profiles associated with foot posture and balance abilities of elite tennis players during normal gait to understand how foot loading patterns result from habitual paces that may be derived from intensive tennis training and competition. A cross-sectional comparative study is conducted on 95 male college elite tennis players (mean age: 20.2 ± 1.2 years) and 100 male recreational tennis players (mean age: 19.8 ± 0.9 years). Bipedal plantar pressure distributions (PPDs) associated with arch index (AI) and centers of gravity balance are explored through the plantar pressure device. The foot posture is estimated to determine the rearfoot postural alignment. During the midstance phase of walking with a normal gait, the bipedal AI values of the elite group are significantly lower, indicating that they have high-arched feet. Additionally, the elite group experienced higher PPDs at the lateral regions of their longitudinal arches and heels and relatively lower PPDs at the medial portions of both feet. Rearfoot postural alignment resonance analysis of the PPDs suggests that the elite group experienced foot supination associated with cuboid dropped. Moreover, the right foot bears heavier centers of gravity balance in the present study. The elite tennis players in the study are categorized as having high-arched supination with cuboids dropped when performing daily habitual paces. This finding warrants further investigation into the correlation between possible injuries and daily habitual paces that may result from tennis' intensive training and competition.

Characteristics of Plantar Pressure with Foot Postures and Lower Limb Pain Profiles in Taiwanese College Elite Rugby League Athletes.

BACKGROUND: This study aimed to explore the differences in the distributions of plantar pressure in static and dynamic states and assess the possible pain profiles in the lower limb between elite rugby league athletes and recreational rugby players. METHODS: A cross-sectional study of 51 college elite rugby athletes and 57 recreational rugby players was undertaken. The arch index (AI) and plantar pressure distributions (PPDs) with footprint characteristics were evaluated via the JC Mat. Rearfoot alignment was examined to evaluate the static foot posture. The elite group's lower-limb pain profiles were examined for evaluating the common musculoskeletal pain areas. RESULTS: The recreational group's AI values fell into the normal range, whereas the elite group's arch type fell into the category of the low arch. Results from the elite group were: (1) the PPDs mainly exerted on the entire forefoot and lateral midfoot regions in static standing, and transferred to the forefoot region during the midstance phase of walking; (2) the static rearfoot alignment matched the varus posture pattern; (3) the footprint characteristics illustrated the features of low-arched, supinated, dropped metatarsal heads and dropped cuboid feet; and (4) the phalanx and metatarsophalangeal joints, and the abductor hallucis and abductor digiti minimi of the plantar plate were common musculoskeletal pain areas. CONCLUSIONS: Characteristics of higher plantar loads beneath forefoot and midfoot associated with low-arched supinated feet in bipedal static stance could be the traceable features for the foot diagram of elite rugby league athletes. The limb pain profiles of the elite rugby league athletes within this study echoed the literature on rugby injuries, and reflected the features of metatarsophalangeal joint pains and dropped cuboids. The relationships among the low-arched supinated feet, metatarsophalangeal joint pains and cuboid syndrome are worth further studies.

Clinical efficacy of acupuncture for pain relief from renal colic: A meta-analysis and trial sequence analysis.

Background: This meta-analysis aimed at investigating the efficacy of acupuncture for relieving renal colic and reducing the risk of analgesic-related complications. Methods: Randomized controlled trials (RCTs) comparing the efficacy of acupuncture (acupuncture group) with conventional interventions (control group) were screened from MEDLINE, EMBASE, Cochrane library databases, China Knowledge Network (CNKI), and Airiti Library till July 15, 2022. The primary outcome was the rate of effective pain relief (response rate), while secondary outcomes included the time of onset of pain relief, visual analog scale (VAS) at 30-60 min and risk of side effects. Results: Thirteen eligible studies involving 1,212 participants published between 1992 and 2021 were analyzed. Compared with the control group, patients receiving acupuncture had a higher overall response rate [risk ratio (RR) = 1.12, 95% CI: 1.05-1.19, p = 0.0002, I 2 = 41%, 1,136 patients] (primary outcome) and a faster pain relief [MD = -10.74 min, 95% CI: -12.65 to -8.82, p < 0.00001, I 2 = 87%, 839 patients]. Patients receiving acupuncture had a lower pain score [MD = -0.65, 95% CI: -1.09 to -0.21, p = 0.21, I 2 = 55%, 327 patients] and risk of side effects (RR = 0.11, 95% CI: 0.04-0.26, p < 0.00001, I 2 = 0, 314 patients) compared to those receiving conventional interventions. Results from trial sequence analysis revealed sufficient evidence supporting the beneficial effects of acupuncture on response rate, time to pain relief, and pain score at 30-60 min. Conclusion: Compared with conventional analgesic-based interventions, acupuncture can more efficiently relieve renal colic with fewer adverse effects. The limited number and quality of included studies warrant more clinical RCTs to support our findings. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42022346714.

Relationships between Plantar Pressure Distribution and Rearfoot Alignment in the Taiwanese College Athletes with Plantar Fasciopathy during Static Standing and Walking.

BACKGROUND: Plantar fasciopathy (PF) is usually related to changes in foot arch, foot shape and rearfoot posture. However, little research has been implemented by using large-scale datasets, and even less has been conducted centering on plantar pressure distributions (PPDs) of different genders of PF athletes. This study aimed to investigate the relationships among the arch index (AI), the PPDs and the rearfoot postural alignment in hundreds of college athletes with PF during static standing and walking. METHODS: Cross-sectional study of 100 male and 102 female athletes with PF was undertaken. The PF athletes' pain assessment and self-reported health status were examined for evaluating their musculoskeletal painful areas. RESULTS: The PF athletes' PPDs mainly concentrated on inner feet in static standing, and transferred to lateral forefeet during the midstance phase of walking. The males' PPDs from the static standing to the midstance phase of walking mainly transferred to anterolateral feet. The females' PPDs mainly transferred to posterolateral feet. The PF athletes' static rearfoot alignment matched the valgus posture pattern. The medial band of plantar fascia and calcaneus were the common musculoskeletal pain areas. CONCLUSIONS: Characteristics of higher plantar loads beneath medial feet associated with rearfoot valgus in bipedal static stance could be the traceable features for PF-related foot diagrams. Higher plantar loads mainly exerted on the lateral forefoot during the midstance phase of walking, and specifically concentrated on outer feet during the transition from static to dynamic state. Pain profiles seem to echo PPDs, which could function as the traceable beginning for the possible link among pronated low-arched feet, PF, metatarsalgia, calcanitis and Achilles tendinitis.